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  4. Recombinant Mouse Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (Atp2a1), partial

Recombinant Mouse Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (Atp2a1), partial

  • 中文名称：
    Recombinant Mouse Sarcoplasmic/endoplasmic reticulum calcium ATPase 1(Atp2a1) ,partial
  • 货号：
    CSB-YP819187MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Sarcoplasmic/endoplasmic reticulum calcium ATPase 1(Atp2a1) ,partial
  • 货号：
    CSB-EP819187MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Sarcoplasmic/endoplasmic reticulum calcium ATPase 1(Atp2a1) ,partial
  • 货号：
    CSB-EP819187MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Sarcoplasmic/endoplasmic reticulum calcium ATPase 1(Atp2a1) ,partial
  • 货号：
    CSB-BP819187MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Sarcoplasmic/endoplasmic reticulum calcium ATPase 1(Atp2a1) ,partial
  • 货号：
    CSB-MP819187MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Atp2a1
  • Uniprot No.：
    Q8R429
  • 别名：
    Atp2a1; Sarcoplasmic/endoplasmic reticulum calcium ATPase 1; SERCA1; SR Ca(2+)-ATPase 1; EC 7.2.2.10; Calcium pump 1; Calcium-transporting ATPase sarcoplasmic reticulum type; fast twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
  • 基因功能参考文献：
    1. Our results indicate that the phospholipid headgroup PC:PE negatively correlated and could potentially contribute to reductions in SERCA activity seen in functionally overloaded plantaris. PMID: 29534725
    2. CAPN3 deficiency leads to degradation of SERCA proteins and Ca2+ dysregulation in the skeletal muscle. PMID: 27055500
    3. Ebf3 binds directly to the promoter of Atp2a1 and synergises with MyoD in the induction of Atp2a1 PMID: 24786561
    4. Formalin evokes calcium transients from the endoplasmatic reticulum via SERCA1-dependent, TRPA1-independent mechanism that may underlie formaldehyde-induced pan-neuronal excitation and subsequent inflammation. PMID: 25875358
    5. SERCA1b is considered to play an essential role in the regulation of [Ca2+]i and its ab ovo gene silencing results in decreased skeletal muscle differentiation. PMID: 25893964
    6. Data show that in healthy transgenic mice, cardiac-specific sarcoplasmic reticulum calcium ATPase SERCA1a expression increased active cell-surface glucose transporter GLUT4 and glucose uptake in the myocardium. PMID: 25615793
    7. Data suggest that the cardiac depressant properties of neuronostatin possibly associated with loss of sarcoplasmic reticulum Ca2+-ATPase SERCA phosphorylation. PMID: 25012062
    8. Results indicated that sine oculis homeobox 1 (Six1) overexpression could significantly promote the expression of fast-type muscle genes Atp2a1, Srl, and Mylpf. PMID: 23613228
    9. Protein levels of CSQ1, SERCA1, and SERCA2 are re-adjusted in skeletal muscles depending on the demands of diverse exercise training programs. PMID: 22466636
    10. dystrophic phenotype observed in delta-sarcoglycan-null (Sgcd(-/-)) mice and dystrophin mutant mdx mice is dramatically improved by skeletal muscle-specific overexpression of sarcoplasmic reticulum Ca(2+) ATPase 1 (SERCA1) PMID: 21285509
    11. Targeted disruption of the gene encoding this protein in the sarco(endo)plasmic reticulum impairs diaphragm function and is lethal in neonatal mice. PMID: 12556521
    12. Sarcolipin is a novel regulator of SERCA pump activity, and its inhibitory effect can be reversed by beta-adrenergic agonists. PMID: 16365042
    13. The results indicate that SERCA overexpression can reduce the *OH-induced contractile dysfunction in murine myocardium, whereas a reduced SR Ca(2+)-ATPase activity aggravates this injury. PMID: 16798816
    14. Our studies point to an important regulation of SERCA1b expression at the protein level and hints to a role in the growth of the developing muscle. PMID: 17010426
    15. Increased TR expression in the hypertrophied heart is associated with an improvement in contractile function and increased SERCA expression. PMID: 17317766
    16. In dystrophin-deficient mdx mice the serca1 is overpression in laryngeal muscles. PMID: 19301368

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Cation transport ATPase (P-type) (TC 3.A.3) family, Type IIA subfamily
  • 数据库链接：

    KEGG: mmu:11937

    STRING: 10090.ENSMUSP00000032974

    UniGene: Mm.35134

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