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  4. Recombinant Mouse Sodium/potassium-transporting ATPase subunit alpha-3 (Atp1a3), partial

Recombinant Mouse Sodium/potassium-transporting ATPase subunit alpha-3 (Atp1a3), partial

  • 中文名称：
    Recombinant Mouse Sodium/potassium-transporting ATPase subunit alpha-3(Atp1a3) ,partial
  • 货号：
    CSB-YP757656MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Sodium/potassium-transporting ATPase subunit alpha-3(Atp1a3) ,partial
  • 货号：
    CSB-EP757656MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Sodium/potassium-transporting ATPase subunit alpha-3(Atp1a3) ,partial
  • 货号：
    CSB-EP757656MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Sodium/potassium-transporting ATPase subunit alpha-3(Atp1a3) ,partial
  • 货号：
    CSB-BP757656MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Sodium/potassium-transporting ATPase subunit alpha-3(Atp1a3) ,partial
  • 货号：
    CSB-MP757656MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Atp1a3
  • Uniprot No.：
    Q6PIC6
  • 别名：
    Atp1a3Sodium/potassium-transporting ATPase subunit alpha-3; Na(+)/K(+) ATPase alpha-3 subunit; EC 7.2.2.13; Na(+)/K(+) ATPase alpha(III) subunit; Sodium pump subunit alpha-3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
  • 基因功能参考文献：
    1. A heterozygous knock-in mouse harboring the D801Y mutation in ATP1A3 was generated. This mice displayed hyperactivity, increased sensitivity to chemically induced epileptic seizures and cognitive deficits. The findings reveal the functional significance of ATP1A3 gene in the control of spatial learning and memory and suggest a link to GABA transmission. PMID: 27549929
    2. Knockout of sodium pump alpha3 subunit gene (Atp1a3(-/-)) results in perinatal seizure and defective respiratory rhythm generation PMID: 28465228
    3. Mice harboring a heterozygous hot spot disease mutation, D801Y suffer abrupt hypothermia-induced dystonia. D-to-Y mutation abolished pump-mediated Na+/K+ exchange. PMID: 28472154
    4. Myshkin mice carrying a wild-type Atp1a3 transgene that confers a 16 % increase in brain-specific total Na(+),K(+)-ATPase activity show significant phenotypic improvements compared with non-transgenic Myshkin mice. PMID: 26463346
    5. Heterozygous Myshkin mice have an amino acid change (I810N) in Na+,K+-ATPase alpha3 and deficits in learning and memory consistent with the cognitive impairment of the vast majority of Alternating Hemiplegia of Childhood patients PMID: 26501181
    6. findings show Atp1a3-deficient heterozygotes exhibited shorter stride length at 4 weeks of age without stress and at later stages under chronic restraint stress; Atp1a3 was widely expressed in the brain and spinal cord of young mice; expression pattern was compatible with movement abnormalities under lack of one of alleles PMID: 24983657
    7. These results shed light on the role of Atp1a3 in the inhibitory synapse, and potential involvement of inhibitory synaptic dysfunction for the pathophysiology of dystonia. PMID: 23652595
    8. The results reveled that the NKAalpha3 subunit is found within gamma-motoneurons of spinal cord. PMID: 23761886
    9. Increased Atp1a3 protein levels in the hippocampus provide evidence for its possible role in mechanisms that parallel memory training. PMID: 22797008
    10. We found that a mutation that decreases neuronal Na(+) ,K(+) -ATPase activity interacts with stress to exacerbate depression. PMID: 21418141
    11. Retinoschisin, the protein involved in the pathogenesis of X-linked juvenile retinoschisis, membrane association is severely impaired in the absence of ATP1A3 and ATP1B2. PMID: 21196491
    12. Stress induced deficits in motor coordination and balance in female Atp1a3 mutant (Het) mice. These mice also exhibited decreased thermal sensitivity, as well as altered circling patterns and monoamine systems. PMID: 20850480
    13. Data show that ATP1alpha(3) is widely expressed in neuronal populations but mainly in GABAergic neurons in areas and nuclei related to movement control, in agreement with rapid-onset of dystonia parkinsonism symptoms. PMID: 21165980
    14. These data demonstrate that, through its interaction with the alpha3 sodium-potassium ATPase, agrin regulates activity-dependent processes in neurons, providing a molecular framework for agrin action in the CNS. PMID: 16630822
    15. while ATP1A3-isoforms regulate sodium and potassium homeostasis in subicular interneurones, ATP1A1-isoforms assume this function in pyramidal cells PMID: 17947306
    16. the basal frequency of myocyte contraction depends on endogenous agrin-alpha3 Na,K-ATPase interaction PMID: 19376779
    17. the Na(+),K(+)-ATPase alpha3 isoform has a role in the control of epileptiform activity and seizure behavior PMID: 19666602

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Cation transport ATPase (P-type) (TC 3.A.3) family, Type IIC subfamily
  • 数据库链接：

    KEGG: mmu:232975

    STRING: 10090.ENSMUSP00000099922

    UniGene: Mm.44101

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