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  4. Recombinant Mouse Type I inositol 3,4-bisphosphate 4-phosphatase (Inpp4a), partial

Recombinant Mouse Type I inositol 3,4-bisphosphate 4-phosphatase (Inpp4a), partial

  • 中文名称：
    小鼠Inpp4a重组蛋白
  • 货号：
    CSB-YP884124MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Inpp4a重组蛋白
  • 货号：
    CSB-EP884124MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Inpp4a重组蛋白
  • 货号：
    CSB-EP884124MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Inpp4a重组蛋白
  • 货号：
    CSB-BP884124MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Inpp4a重组蛋白
  • 货号：
    CSB-MP884124MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Inpp4a
  • Uniprot No.：
    Q9EPW0
  • 别名：
    Inpp4a; Inositol polyphosphate-4-phosphatase type I A; Inositol polyphosphate 4-phosphatase type I; Inositol polyphosphate 4-phosphatase-1; 4-Ptase-1; Type I inositol 3,4-bisphosphate 4-phosphatase; EC 3.1.3.66
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate. Catalyzes also inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current. ...显示更多
  • 基因功能参考文献：
    1. this study shows that the myeloid Inpp4a-knockout mice display impaired bacteria clearance due to decreased inflammatory cytokine production PMID: 27252170
    2. this study shows that FcgammaRIIb drives the sequential dephosphorylation system comprising SHIP1/2 and Inpp4a, and accelerates phagosome acidification PMID: 28409542
    3. This study showed that spontaneous Inpp4a mutations causing cerebellar pathology are impaired in motor functions during the neonatal period. PMID: 25907855
    4. These results suggest a novel mechanism of action of resveratrol in attenuating asthma phenotype by downregulating PI3K-Akt pathway via upregulating INPP4A. PMID: 22986054
    5. INPP4A represents the first signalling protein with a function in neurons to suppress excitotoxic cell death PMID: 20463662
    6. Purkinje cell loss in the Inpp4a(wbl) mutant is due to glutamate excitotoxicity initiated by the climbing fiber, and that Eaat4 may exert a protective effect. PMID: 20011524
    7. Study provides the first evidence that inositol polyphosphate 4-phosphatase-1 controls the activation of Akt and thereby cell proliferation, survival and tumorigenesis. PMID: 19325558

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  • 亚细胞定位：
    Early endosome membrane. Recycling endosome membrane. Cell membrane. Nucleus. Cytoplasm. Cell junction, synapse, postsynaptic density.
  • 蛋白家族：
    Inositol 3,4-bisphosphate 4-phosphatase family
  • 组织特异性：
    Spleen, skeletal muscle, lung and uterus.
  • 数据库链接：

    KEGG: mmu:269180

    STRING: 10090.ENSMUSP00000027287

    UniGene: Mm.5294

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