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  4. Recombinant Rabbit Voltage-dependent P/Q-type calcium channel subunit alpha-1A (CACNA1A), partial

Recombinant Rabbit Voltage-dependent P/Q-type calcium channel subunit alpha-1A (CACNA1A), partial

  • 中文名称：
    Recombinant Rabbit Voltage-dependent P/Q-type calcium channel subunit alpha-1A(CACNA1A) ,partial
  • 货号：
    CSB-YP004397RB
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rabbit Voltage-dependent P/Q-type calcium channel subunit alpha-1A(CACNA1A) ,partial
  • 货号：
    CSB-EP004397RB
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rabbit Voltage-dependent P/Q-type calcium channel subunit alpha-1A(CACNA1A) ,partial
  • 货号：
    CSB-EP004397RB-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rabbit Voltage-dependent P/Q-type calcium channel subunit alpha-1A(CACNA1A) ,partial
  • 货号：
    CSB-BP004397RB
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rabbit Voltage-dependent P/Q-type calcium channel subunit alpha-1A(CACNA1A) ,partial
  • 货号：
    CSB-MP004397RB
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CACNA1A
  • Uniprot No.：
    P27884
  • 别名：
    CACNA1A; CACH4; CACN3; CACNL1A4Voltage-dependent P/Q-type calcium channel subunit alpha-1A; Brain calcium channel I; BI; Calcium channel; L type; alpha-1 polypeptide isoform 4; Voltage-gated calcium channel subunit alpha Cav2.1
  • 种属：
    Oryctolagus cuniculus (Rabbit)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P54282). They are however insensitive to dihyd...显示更多
  • 基因功能参考文献：
    1. Gem contains two candidate inhibitory sites, each capable of producing full inhibition of P/Q-type Ca(2+) channels. PMID: 22589533
    2. describe a CACNA1A mutation (A454T) that disturbs the functional interaction between SNAREs and the poreforming alpha1A subunit, resulting in mutant P/Q channels that are less efficiently coupled to secretion. PMID: 20080591
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Calcium channel alpha-1 subunit (TC 1.A.1.11) family, CACNA1A subfamily
  • 组织特异性：
    Brain specific. Purkinje cells contain predominantly P-type VSCC, the Q-type being a prominent calcium current in cerebellar granule cells.
  • 数据库链接：

    KEGG: ocu:100009265

    UniGene: Ocu.2123

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