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  4. Recombinant Rat Actin, aortic smooth muscle (Acta2)

Recombinant Rat Actin, aortic smooth muscle (Acta2)

  • 中文名称：
    Recombinant Rat Actin, aortic smooth muscle(Acta2)
  • 货号：
    CSB-YP351199RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Actin, aortic smooth muscle(Acta2)
  • 货号：
    CSB-EP351199RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Actin, aortic smooth muscle(Acta2)
  • 货号：
    CSB-EP351199RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Actin, aortic smooth muscle(Acta2)
  • 货号：
    CSB-BP351199RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Actin, aortic smooth muscle(Acta2)
  • 货号：
    CSB-MP351199RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Acta2
  • Uniprot No.：
    P62738
  • 别名：
    Acta2; Actsa; ActvsActin; aortic smooth muscle; Alpha-actin-2) [Cleaved into: Actin; aortic smooth muscle; intermediate form]
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    3-377
  • 氨基酸序列
    EEEDSTAL VCDNGSGLCK AGFAGDDAPR AVFPSIVGRP RHQGVMVGMG QKDSYVGDEA QSKRGILTLK YPIEHGIITN WDDMEKIWHH SFYNELRVAP EEHPTLLTEA PLNPKANREK MTQIMFETFN VPAMYVAIQA VLSLYASGRT TGIVLDSGDG VTHNVPIYEG YALPHAIMRL DLAGRDLTDY LMKILTERGY SFVTTAEREI VRDIKEKLCY VALDFENEMA TAASSSSLEK SYELPDGQVI TIGNERFRCP ETLFQPSFIG MESAGIHETT YNSIMKCDID IRKDLYANNV LSGGTTMYPG IADRMQKEIT ALAPSTMKIK IIAPPERKYS VWIGGSILAS LSTFQQMWIS KQEYDEAGPS IVHRKCF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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Acta2 ELISA kits

靶点详情

  • 功能：
    Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
  • 基因功能参考文献：
    1. considering the steroid hormone imbalance in late life period, as well as, the role of this imbalance in prostatic lesion development and progression, the aim of the study herein was to characterize and correlate prolactin, EGFR, alpha-actin and vimentin immunoreactivity in the prostatic epithelium and stroma of elderly rats, following steroid hormone imbalance. PMID: 27021728
    2. Data suggest that the expression of actin alpha 2 smooth muscle (alpha-SMA) plays certain roles in the neuroma-associated pain, either as a direct cause of pain or as an indirect marker of existence of local mechanical stimuli. PMID: 27021914
    3. Expressions of M2R and M3R mRNA were increased in urothelial cells and decreased in detrusor muscles following chronic cystitis. PMID: 25681120
    4. Smooth muscle alpha-actin is present in the cervix of virgin, 11 day, and 20 day pregnant rats. PMID: 25108144
    5. Data suggest that the myosin-II mediated drebrin A-actin exodus might be an initial event in chemical long-term potentiation (LTP) induction, triggering actin polymerization and spine enlargement. PMID: 24465547
    6. Acta2 is important for myofibroblast cells motility, contraction and regulation of signaling processes during wound healing. PMID: 24204762
    7. Data from several animal models suggest that up-regulation of expression of Tgfb1 (transforming growth factor beta 1) and Acta2 in proximal tubular cells is key to development of renal tubular fibrosis in chronic kidney disease/renal hypertension. PMID: 24601883
    8. Smooth muscle actin expression increased during lung injury induced by hyperoxia, and could play an important role in pulmonary fibrosis remodeling. PMID: 23040780
    9. Smooth muscle alpha-actin was increased on day 9 of bleomycin induced pulmonary fibrosis in rats, and is involved in the mechanism of N-acetylcysteine alleviation of idiopathic pulmonary fibrosis. PMID: 23006535
    10. novel populations of alphaSMA+ precursors of pericytes are born on the subventricular zones then migrate into the peri-infarct region PMID: 22805872
    11. Tendon cells are capable of actively contracting lax tendons through an alpha smooth muscle actin-based mechanism. PMID: 22517354
    12. Hepatocyte growth factor can relieve chronic renal failure, and this protection is associated with the down-regulation of alpha-SMA expression in mesangial cells and renal interstitium. PMID: 22680062
    13. Leptin potentiates acetaldehyde-induced hepatic stellate cell activation and transdifferentiation as evidenced by increased alpha-smooth muscle actin expression. PMID: 21294755
    14. The results suggest that alpha-SMA containing stress fibers contribute to myofibroblast arrhythmogeneicity. After ablation of this cytoskeletal component, cells lose their arrhythmic effects on cardiomyocytes. PMID: 21921266
    15. alpha-SMA expression in renal interstitial fibroblasts, i.e., myofibroblast transdifferentiation, accelerates the contraction of the tubulointerstitial fibrosis tissue via the Ca(2)+-dependent pathway PMID: 21630215
    16. Reactivation of fetal structural genes of vascular smooth muscle alpha-actin and its ectopic expression is associated with the cardiac allograft vasculopathy and fibrosis. PMID: 19411749
    17. The expression of alpha -SMA is increased dramatically during the fibrosis, and is positively associated with the expression of alpha -AR, beta(1)-AR and beta(2)-AR. PMID: 19785950
    18. Transcriptional regulation of a contractile gene by mechanical forces applied through integrins in osteoblasts PMID: 11953441
    19. smooth muscle alpha-actin expression requires a transforming growth factor-beta control element PMID: 12970361
    20. Tacrolimua and sirolimus both increased kidney transplantation TGF-beta1 and alpha-SMA levels. PMID: 15316360
    21. There was a significant increase in smooth muscle alpha-actin located around regenerating hepatic nodules. PMID: 15814362
    22. results provide the first in vivo evidence for the importance of the intronic CArG and transforming growth factor-beta1 control element cis-elements in the regulation of alpha-SMA expression in myofibroblasts in granulation tissue PMID: 15855636
    23. Myometrial expression of alpha-SM-actin mRNA and protein was high throughout pregnancy. PMID: 15972885
    24. Results identify alpha-smooth muscle actin as a mechanosensitive protein that is recruited to stress fibers under high tension. PMID: 16401722
    25. Force-mediated actin filament assembly promotes nuclear translocation of MRTF and subsequent activation of the SMA promoter to enhance SMA expression. PMID: 17456553
    26. Olfactory ensheathing cells synthesize smooth muscle alpha-actin (and a variety of actin-binding proteins including caldesmon) providing compelling evidence that these cells are different from Schwann cells. PMID: 17492622
    27. These findings indicate the existence of alpha-smooth muscle actin-positive endothelial cells in adult aortic endothelium and the possible association with progression of atherosclerosis. PMID: 19285011

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Actin family
  • 数据库链接：

    KEGG: rno:81633

    UniGene: Rn.195319

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