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  4. Recombinant Rat Afadin (Mllt4), partial

Recombinant Rat Afadin (Mllt4), partial

  • 中文名称：
    Recombinant Rat Afadin(Mllt4) ,partial
  • 货号：
    CSB-YP014636RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Afadin(Mllt4) ,partial
  • 货号：
    CSB-EP014636RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Afadin(Mllt4) ,partial
  • 货号：
    CSB-EP014636RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Afadin(Mllt4) ,partial
  • 货号：
    CSB-BP014636RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Afadin(Mllt4) ,partial
  • 货号：
    CSB-MP014636RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Afdn
  • Uniprot No.：
    O35889
  • 别名：
    Afdn; Af6; Mllt4Afadin; Afadin adherens junction formation factor; Protein Af-6
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. May play a key role in the organization of epithelial structures of the embryonic ectoderm. Essential for the organization of adherens junctions.
  • 基因功能参考文献：
    1. Short splicing isoform of afadin (s-Afadin) blocks the R-Ras-mediated membrane translocation of long splicing isoform of afadin (l-afadin) and axon branching by inhibiting the binding of l-afadin to R-Ras. PMID: 25808489
    2. afadin bi-directional shuttling from the cytosol to synapses and the nucleus promotes spine plasticity and histone modifications PMID: 24567331
    3. afadin is required for the maintenance of dendritic structure and excitatory tone. PMID: 22948147
    4. Rap1 bimodally regulates spine morphology: activated Rap1 recruits PDZ domain-containing protein AF-6 to plasma membrane and induces spine neck elongation, while inactive Rap1 dissociates AF-6 from membrane and induces spine enlargement. PMID: 16301177
    5. AF6/s-afadin is a candidate for mediating control of cellular growth processes by regulated translocation to the nucleus. PMID: 17013812

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  • 亚细胞定位：
    Cell junction, adherens junction.
  • 组织特异性：
    Isoform 1 is widely expressed, including in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Isoform 2 is mainly expressed in the brain.
  • 数据库链接：

    KEGG: rno:26955

    UniGene: Rn.58

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