Your Good Partner in Biology Research

中文简体

CSF2｜ CTLA4｜ DLL3｜ EGFR｜ IL4｜ IL4R｜ LAG3｜ MSTN｜ NECTIN4｜ NT5E｜ SEZ6｜ TM4SF1｜ TNFSF13｜ TPO

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Rat Beta-arrestin-1 (Arrb1)

Recombinant Rat Beta-arrestin-1 (Arrb1)

  • 中文名称：
    Recombinant Rat Beta-arrestin-1(Arrb1)
  • 货号：
    CSB-YP002134RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Beta-arrestin-1(Arrb1)
  • 货号：
    CSB-EP002134RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Beta-arrestin-1(Arrb1)
  • 货号：
    CSB-EP002134RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Beta-arrestin-1(Arrb1)
  • 货号：
    CSB-BP002134RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Beta-arrestin-1(Arrb1)
  • 货号：
    CSB-MP002134RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Arrb1
  • Uniprot No.：
    P29066
  • 别名：
    Arrb1; Beta-arrestin-1; Arrestin beta-1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-418
  • 氨基酸序列
    MGDKGTRVFK KASPNGKLTV YLGKRDFVDH IDLVDPVDGV VLVDPEYLKE RRVYVTLTCA FRYGREDLDV LGLTFRKDLF VANVQSFPPA PEDKKPLTRL QERLIKKLGE HAYPFTFEIP PNLPCSVTLQ PGPEDTGKAC GVDYEVKAFC AENLEEKIHK RNSVRLVIRK VQYAPERPGP QPTAETTRQF LMSDKPLHLE ASLDKEIYYH GEPISVNVHV TNNTNKTVKK IKISVRQYAD ICLFNTAQYK CPVAMEEADD TVAPSSTFCK VYTLTPFLAN NREKRGLALD GKLKHEDTNL ASSTLLREGA NREILGIIVS YKVKVKLVVS RGGLLGDLAS SDVAVELPFT LMHPKPKEEP PHREVPESET PVDTNLIELD TNDDDIVFED FARQRLKGMK DDKDEEDDGT GSPHLNNR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated so...显示更多
  • 基因功能参考文献：
    1. Tyrosine hydroxylase upregulate beta-arrestin-1 in astrocytes to facilitate endocytosis of beta2-AR, required for endosomal ERK activation to drive the differentiation process. PMID: 26399643
    2. Results suggested that beta-arr1 and 2 may differently modulate mGluR7 signaling in developmental sevoflurane neurotoxicity PMID: 26621121
    3. Microinfusions of Arrb1 antisense oligodeoxynucleotides into female rat hypothalamus knocked down Arrb1 and prevented estradiol benzoate-induced lordosis behavior. PMID: 25803606
    4. The studies reveal how CB1 receptor activation translates into beta-arrestin 1/ beta-arrestin 2 signaling and identify a mechanism to control this pathway. PMID: 25081814
    5. oxymatrine can attenuate the development of UC by regulating the DOR-beta-arrestin1-Bcl-2 signal transduction pathway. PMID: 25480575
    6. The conformational differences between beta-arrestin1 and beta-arrestin2 in both the basal and pre-activated states might determine their different receptor selectivities and different cellular functions. PMID: 25542150
    7. Arrestins coordinate AT1 receptor regulation of ERK1/2 and Akt activity and stimulate protein translation via both Akt-mTOR-p70/85S6K and ERK1/2-p90RSK pathways. PMID: 25081544
    8. crystal structure of beta-arrestin-1 (also called arrestin-2) in complex with a fully phosphorylated 29-amino-acid carboxy-terminal peptide derived from the human V2 vasopressin receptor (V2Rpp) PMID: 23604254
    9. The interaction of beta-arrestin-1 with G-alpha-s regulates the activity of G-alpha-s. PMID: 23353685
    10. Suggest that following antidepressant treatment, beta-arrestin1 generates a transcription complex involving CREB essential for GDNF expression and release. PMID: 21223624
    11. Inhibition of adrenal beta arrestin 1 (betaarr1), either directly or by treatment to prevent receptor-betaarr1 coupling, might be of therapeutic value for curbing heart failure-exacerbating hyperaldosteronism. PMID: 21232674
    12. beta-Arrestin 1 interacts with, and acts as an adaptor for AIP4, an E3 ubiquitin ligase responsible for TRPV4 ubiquitination. PMID: 20650893
    13. Treatment of Rat-1 cells for 12 h with insulin induces an approximately 50% decrease in cellular beta-arrestin-1 content due to ubiquitination of beta-arrestin-1 and proteosome-mediated degradation. PMID: 12167719
    14. by recruiting phosphodiesterase to activated beta2-adrenergic receptors in the plasma membrane, beta arrestins target cAMP degradation to sites of localized PKA activity at the plasma membrane PMID: 12399592
    15. beta-arrestin is directly involved in glutamate-stimulated MAP kinase activation by acting as a signaling molecule. PMID: 12519791
    16. Replacement of intracellular loop 3 and the COOH tail of the NK1R with comparable domains of the NK3R diminished colocalization of the NK1R with beta-arrestin 1 and accelerated resensitization to that of the NK3R. PMID: 12958028
    17. betaArr1 may be involved in modulation of specific tactile stimulation from the skin in addition to nociception. PMID: 14519533
    18. beta-arrestin-1 expression is increased after cerebral hypoxia/ischemia. PMID: 15017017
    19. NF-kappaB activation and Ca2+/calcineurin signaling have roles in platelet-activating factor-induced chemokine gene expression and are inhibited by receptor phosphorylation and beta-arrestin recruitment PMID: 15308653
    20. Data suggest that beta-arrestin-1 can alter insulin signaling by inhibiting insulin-induced proteasomal degradation of insulin receptor substrate 1. PMID: 15456867
    21. phosphorylation-independent mechanisms regulate beta-arrestin association and internalization of BLT1 PMID: 15561704
    22. beta-arrestin2 utilizes mu-adaptin as an endocytic partner; the inability of beta-arrestin1 to sustain a similar degree of interaction with mu-adaptin may result from coordination of Tyr-54 by neighboring residues or its modification by Src kinase PMID: 17456469
    23. the "receptor-bound" conformations of beta-arrestins1 and 2 are different PMID: 17513300
    24. beta-arrestins regulate protein synthesis PMID: 18276584
    25. These studies indicate that beta-arrestin-1 plays a role in GLP-1 signaling leading to insulin secretion, defining a previously undescribed mechanism for GLP-1 action. PMID: 18445652
    26. beta-arrestin cleavage upon AT(1)R stimulation is a part of the unraveling beta-arrestin-mediated G protein-coupled receptor signaling diversity PMID: 18505723
    27. These findings demonstrate differences in internalization between the alpha1a- and alpha1b-AR and provide evidence that the lack of significant endocytosis of the alpha1a-AR is linked to its poor interaction with beta-arrestins as well as with AP50. PMID: 18523139
    28. a novel signaling pathway underlying this AT(1)R-dependent aldosterone production mediated by beta-arrestin-1 PMID: 19289825
    29. results demonstrate that 17-beta-Estradiol -mediated neuroprotection and ERK activation involve ERalpha activation of G-protein- and beta-arrestin-mediated mechanisms PMID: 19339617

    收起更多

  • 亚细胞定位：
    Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit. Cell projection, pseudopodium. Cytoplasmic vesicle.
  • 蛋白家族：
    Arrestin family
  • 组织特异性：
    Predominantly localized in neuronal tissues and in the spleen.
  • 数据库链接：

    KEGG: rno:25387

    STRING: 10116.ENSRNOP00000046069

    UniGene: Rn.34876

Most popular with customers

产品中心
特别关注


X