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  4. Recombinant Rat Breast cancer anti-estrogen resistance protein 1 (Bcar1), partial

Recombinant Rat Breast cancer anti-estrogen resistance protein 1 (Bcar1), partial

  • 中文名称：
    Recombinant Rat Breast cancer anti-estrogen resistance protein 1(Bcar1) ,partial
  • 货号：
    CSB-YP733970RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Breast cancer anti-estrogen resistance protein 1(Bcar1) ,partial
  • 货号：
    CSB-EP733970RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Breast cancer anti-estrogen resistance protein 1(Bcar1) ,partial
  • 货号：
    CSB-EP733970RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Breast cancer anti-estrogen resistance protein 1(Bcar1) ,partial
  • 货号：
    CSB-BP733970RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Breast cancer anti-estrogen resistance protein 1(Bcar1) ,partial
  • 货号：
    CSB-MP733970RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Bcar1
  • Uniprot No.：
    Q63767
  • 别名：
    Bcar1; Cas; CrkasBreast cancer anti-estrogen resistance protein 1; CRK-associated substrate; p130cas
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. Implicated in induction of cell migration and cell branching. Involved in the BCAR3-mediated inhibition of TGFB signaling.
  • 基因功能参考文献：
    1. Cas plays pivotal roles in liver development through the reorganization of the actin cytoskeleton and formation of fenestrae in sinusoidal endothelial cells. PMID: 20623582
    2. Analysis of protein domains of Cas protein in rat. PMID: 12011056
    3. degradation of p130cas during apoptosis is modulated in a phosphorylation-dependent manner PMID: 12480533
    4. in cells transformed by the v-crk oncogene, the adapter protein Cas forms a stable complex with the p85 regulatory subunit of phosphatidylinositol 3'-kinase (PI3K) coincident with the appearance of Cas-associated PI3K activity PMID: 12692262
    5. upregulation of PTP-PEST is both necessary and sufficient to explain NO-induced p130cas dephosphorylation in vascular smooth muscle PMID: 12714323
    6. tyrosine phosphorylation of Crk-associated substrate in pancreatic beta-cells is stimulated by glucose PMID: 12746446
    7. glutamic acid mutation of tyrosine 635 makes SHEP1 unable to promote Cas-Crk association, membrane ruffling, and cell migration toward epidermal growth factor (EGF), implying that these activities of SHEP1 depend upon a physical interaction with Cas PMID: 15272013
    8. functional domain analysis of the docking protein p130Cas PMID: 15485652
    9. the solution structure shows that the p130cas serine-rich domain is a four-helix bundle PMID: 15795225
    10. Data suggest that IGF-I induces smooth muscle cell motility by increasing phosphotyrosine levels of p130(cas) and activating Rac1, and that nitric oxide decreases motility by activating PTP-PEST. PMID: 16354758
    11. These data are the first to implicate Crk-associated substrate in the signal transduction of 5-HT. PMID: 16861698
    12. Abl may play a pivotal role in mediating CAS phosphorylation, the assembly of the multiprotein complex, actin assembly, and constriction in resistance arteries PMID: 17615370
    13. Caspase-mediated cleavage of p130Cas generates a 31 kDa fragment, inhibits p21Cip1 transcription and acts as an amplifier of apoptotic signalling PMID: 17617061

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  • 亚细胞定位：
    Cell junction, focal adhesion. Cytoplasm. Cell projection, axon.
  • 蛋白家族：
    CAS family
  • 组织特异性：
    Widely expressed. Higher expression in lung, intestine and testis.
  • 数据库链接：

    KEGG: rno:25414

    STRING: 10116.ENSRNOP00000039940

    UniGene: Rn.40101

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