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  4. Recombinant Rat Calcium-activated potassium channel subunit alpha-1 (Kcnma1), partial

Recombinant Rat Calcium-activated potassium channel subunit alpha-1 (Kcnma1), partial

  • 中文名称：
    大鼠Kcnma1重组蛋白
  • 货号：
    CSB-YP723487RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Kcnma1重组蛋白
  • 货号：
    CSB-EP723487RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Kcnma1重组蛋白
  • 货号：
    CSB-EP723487RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Kcnma1重组蛋白
  • 货号：
    CSB-BP723487RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Kcnma1重组蛋白
  • 货号：
    CSB-MP723487RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Kcnma1
  • Uniprot No.：
    Q62976
  • 别名：
    Kcnma1; KcnmaCalcium-activated potassium channel subunit alpha-1; BK channel; BKCA alpha; Calcium-activated potassium channel; subfamily M subunit alpha-1; K(VCA)alpha; KCa1.1; Maxi K channel; MaxiK; Slo-alpha; Slo1; Slowpoke homolog; Slo homolog
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, ...显示更多
  • 基因功能参考文献：
    1. Results show that outward K+ currents, mainly BKCa currents, are significantly upregulated in Muller cells in chronic ocular hypertension rats and these upregulated currents attenuate Muller cells gliosis; and further provide evidence showing that the upregulation of BKCa currents in Muller cells is mediated by the dopamine (DA)/D1 receptor (D1R) system. PMID: 29508439
    2. EDHF-mediated relaxations in superior mesenteric arteries are impaired in spontaneously hypertensive rats, and utilize components of BKCa in addition to SKCa/IKCa channel activities. PMID: 29558628
    3. Enhanced activity of VSM BKCa channels, associated with up-regulation of channel beta1 subunit and with a higher intracellular Ca(2+) mobilization, contributes to the preserved NO-mediated vasodilatation and basal tone of coronary arteries in obesity. PMID: 28672269
    4. Thiourea derivative, compound 326, stimulates the activity of large-conductance, calcium-activated potassium channels. PMID: 28075010
    5. Taken together, BKCa channel activation attenuates these Ca(2+) oscillations due to depolarization-synchronized Ca(2+) influx through VDCCs and results in a recovery of reduced melatonin secretion during parasympathetic nerve activity. BKCa channels may play a physiological role for melatonin production via a negative-feedback mechanism. PMID: 26791489
    6. Results showed that BK-knockout osteoblasts displayed low proliferation and impaired mineralization ability providing further evidence that BK channel is critical for osteoblast function. PMID: 27329042
    7. Coupling of Orai1-BKCa channel has a hyperpolarizing effect in mesenteric artery smooth muscle. PMID: 26755740
    8. SLO2 Channels Are Inhibited by All Divalent Cations That Activate SLO1 K+ Channels PMID: 26823461
    9. Data show that large-conductance calcium-activated potassium channels, alpha subunit (Kcnma1) activation will be limited if intracellular Ca(2+) is not elevated. PMID: 26277265
    10. Echinacoside suppresses NE-induced contraction of rat pulmonary artery by reducing intracellular Ca(2+) levels, and induces its relaxation through the NO-cGMP pathway and opening of BKCa channels. PMID: 25864652
    11. Data from in vitro studies suggest that genistein and magnesium (sometimes used as dietary supplements) enhance vasodilation of vascular smooth muscle via mechanisms involving BK(Ca) and eNOS (endothelial nitric oxide synthase 3). PMID: 25494655
    12. impairment of cAMP-induced vasodilator function mediated by BKCa and KV channels in resistance vessels of conscious rats with genetic hypertension PMID: 24397812
    13. Pathological stretch may induce the endoplasmic reticulum stress in vascular smooth muscle cells (VSMC), which affects the alternative splicing and activity of BK channels, and subsequently modulates VSMC differentiation. PMID: 25481230
    14. and its coexpression with CaSR and TRPV1 channels in rat bronchopulmonary sensory neurons. PMID: 25192641
    15. involved in inflammatory response and subsequent lung injury during acute pancreatitis PMID: 24836752
    16. KCNMA1 was able to enhance the positive effect of MSCs in the treatment of diabetes-associated erectile dysfunction PMID: 23646921
    17. Our results suggest that genistein amplifies BK(Ca) currents at a high [Mg(2+)]i, but inhibits BK(Ca) currents at a low [Mg(2+)]i PMID: 24729485
    18. The expression of BKca channel in vascular smooth muscle cells from mesenteric arteries of spontaneously hypertensive rats increases with age. PMID: 23872879
    19. This result suggests the involvement of the BKCa channel in hypoxia/reoxygenation-induced apoptosis. PMID: 23653329
    20. Greater catecholamine secretion from DOCA-salt cells results in altered vesicular release from functionally impaired large conductance, calcium-activated and ATP-sensitive K+ channels. PMID: 23937098
    21. The lateral movement of BKCa channels is greatly influenced by palmitoylation. PMID: 24462688
    22. In dextran sulfate-induced colitis, active K(+) secretion involves upregulation of Kcnma1 channel expression. PMID: 23986198
    23. Transcript analysis and expression in adult cardiomyocytes leads to the discovery of a 50-aa C-terminal splice insert as essential for the mitochondrial targeting of mitoBK(Ca) PMID: 23754429
    24. there is a dose effect for exercise training volume for the activation of BK(Ca) channels in vascular SMCs, which contributes to improvement of the arterial function in thoracic aortas. PMID: 22350354
    25. Patch-clamp experiments combined with transcript scanning of the Kcnma1 gene encoding the alpha subunit of the BK channel were performed in rat slow-twitch soleus (Sol) and fast-twitch flexor digitorum brevis (FDB) skeletal muscles. PMID: 22808126
    26. The BKCa current density is extremely correlative with blood pressure and is attenuated with aging. PMID: 21158046
    27. Results indicated that BK channels are the determinant of coronary arterial tone. Impaired BK channel function is associated with down-regulation of BK-b(1) expression and reduction of the b(1)-mediated BK channel activation in diabetic vessels. PMID: 22882938
    28. these data indicate that BK(Ca) channels of the neurons in neonatal rostral ventrolateral medulla could be involved in CO-mediated central regulation of respiratory rhythm in medullary slices PMID: 22633934
    29. study concludes that endothelial cell BK channel activity is heme oxygena dependent in the absence of the inhibitory effect of the Cav-1 scaffolding domain PMID: 22555843
    30. The data suggested that P2Y1 signaling leading to activation of small and large calcium-activated potassium channels may be important in regulating the activity of medium-sized neurons in the striatum. PMID: 22131374
    31. The presence and localization of both mRNA and protein expression of the BK(Ca) channel in the smooth muscle cell layer in rat basilar, middle cerebral, and middle meningeal arteries, is shown. PMID: 18953570
    32. BKCA (potassium large conductance calcium-activated channels) are involved in adenosine A1 receptor-induced postconditioning in a rat heart embryo cell model hypoxia system in vitro. PMID: 21186374
    33. c-Phospholipase A2 is likely physically associated with Large conductance, calcium-activated potassium channel proteins at the cell surface. PMID: 16997278
    34. study demonstrates that K(Ca)1.1 channels are uniquely expressed in unmyelinated C-type vagal afferents and do not contribute to the dynamic discharge characteristics of myelinated A-type vagal afferents PMID: 21325638
    35. functional characteristics of X1 variant may be important for a subpopulation of BK channels in brain, while "silent" truncated variants X2(92) and X2(188) may play role as modulators of other BK channel variants similar to beta subunits. PMID: 20938677
    36. Reduction in Kcnma1 gene expression is associated with a relative increase of STRess axis-regulated EXon of Kcnma1 splice variant. Relative expression of STREX variant mRNA was increased at 10 days and at more than 1 month following status epilepticus. PMID: 20933547
    37. Data show that basal (high frequency) outer hair cells had abundant BK channel immunoreactivity and BK currents contributed significantly to both voltage-gated and ACh-evoked K(+) currents. PMID: 21079807
    38. The KCNMA1 expression in the ductus arteriosus decreased with advancing development. PMID: 20936291
    39. Hypobaric chronic hypoxia induces increased endothelial BK(Ca) channel activity that contributes to reduced myogenic responsiveness and endothelial cell and vascular smooth muscle cell hyperpolarization. PMID: 20817829
    40. vasoconstrictor TP receptor and MaxiK-channel direct interaction facilitates G-protein-independent TP to MaxiK trans-inhibition, which would promote vasoconstriction. PMID: 20959415
    41. BK(Ca) channel are more dependent on voltage and more sensitive to [Ca(2+)](i) in adult hippocampal neurons than in cultured or immature neurons and may be responsible for the shortened duration of action potential in hippocampal neurons of adult rat. PMID: 11846964
    42. Results show that leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels. PMID: 11889470
    43. Nitric oxide enhances Ca(2+)-dependent K(+) channel activity in rat carotid body cells. PMID: 11889563
    44. Steady-state and closed-state inactivation properties PMID: 11964233
    45. cAMP-dependent vasodilators activate BK(Ca) channels in PASMC of rats via PKG-dependent and PKA-independent signaling pathways, which suggests cross-activation between cyclic nucleotide-dependent protein kinases in pulmonary arterial smooth muscle PMID: 12547730
    46. large conductance Ca2+-activated K+ channel surface expression is reduced in both rat and mouse late pregnant myometrium PMID: 12952984
    47. electrophysiological and structural evidence showing that haem directly regulates cloned human Slo1 channels and wild-type BK channels in rat brain PMID: 14523450
    48. Slo gene-encoded BK potassium channels alternative splicing variants are found with and without the 'STREX' exon. In the adrenal medulla, castration increased STREX transcripts slightly and decreased STREX representation in the pituitary. PMID: 15049854
    49. Data suggest that the regulation of STREX splicing directed by estrogen and Pg provides a mechanism for Slo's PKA-related phenotypic alteration with pregnancy. PMID: 16102753
    50. Slo1 is accumulated in axons and synaptic terminal zones associated with glutamatergic synapses in hippocampus and GABAergic synapses in cerebellum. PMID: 16566008

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.; [Isoform 7]: Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Has a dominant-negative effect on other isoforms, preventing their localization to the cell membrane.
  • 蛋白家族：
    Potassium channel family, Calcium-activated (TC 1.A.1.3) subfamily, KCa1.1/KCNMA1 sub-subfamily
  • 数据库链接：

    KEGG: rno:83731

    UniGene: Rn.30616

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