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  4. Recombinant Rat Caspase-12 (Casp12), partial

Recombinant Rat Caspase-12 (Casp12), partial

  • 中文名称：
    Recombinant Rat Caspase-12(Casp12) ,partial
  • 货号：
    CSB-YP821621RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Caspase-12(Casp12) ,partial
  • 货号：
    CSB-EP821621RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Caspase-12(Casp12) ,partial
  • 货号：
    CSB-EP821621RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Caspase-12(Casp12) ,partial
  • 货号：
    CSB-BP821621RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Caspase-12(Casp12) ,partial
  • 货号：
    CSB-MP821621RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Casp12
  • Uniprot No.：
    Q920D5
  • 别名：
    Casp12Caspase-12; CASP-12; EC 3.4.22.-
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 表达区域：
    -
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in the activation cascade of caspases responsible for apoptosis execution.
  • 基因功能参考文献：
    1. these results suggest that emodin inhibits SIRS in rats with SAP by inducing circulating neutrophil apoptosis via the Ca(2+)-calpain 1-caspase 12-caspase 3 signaling pathway PMID: 28078280
    2. caspase-12 plays an important role in stretch-induced apoptosis that is associated by endoplasmic reticulum stress by activating caspase-3. PMID: 26801321
    3. Tauroursodeoxycholic acid inhibits the expression of caspase-12 in rat neurons after spinal cord injury, reducing apoptosis and exerting neuroprotective effects. PMID: 26884858
    4. Endoplasmic reticulum stress related factor ATF6 and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy. PMID: 26261584
    5. This study demonstred that caspase-12 mRNA in the hippocampus was elevated in subarachnoid hemorrhage animals. PMID: 25219918
    6. SMI could alleviate myocardial ER stress and caspase-12 dependent apoptosis, which subsequently helped to improve the heart function of rats with DOX-CM. PMID: 25839043
    7. Results showed that, following thapsigargin treatment, more Purkinje neuron dendrites in the ethanol-fed group expressed activated caspase 12 PMID: 24976582
    8. Activation of endoplasmic reticulum stress increases apoptosis and expression of CASP12 in the renal cortex of diabetic rats. PMID: 21845883
    9. The protective mechanisms of fused FNK protein therapy might involve the inhibition of apoptotic pathways through caspase-12, but not through Bcl-2. PMID: 22099262
    10. Mitochondrial caspase-9 is not a downstream substrate of endoplasmic reticulum-specific caspase-12 . PMID: 21784110
    11. Processing of procaspase-12 was mediated by NMDA receptor and calpain activation PMID: 21525936
    12. This result suggests that the fragmentation of caspase-12 and the subsequent nuclear translocation of these fragments are involved in the brain infarction process in rats. PMID: 21476018
    13. Electrical stimulation increased valosin-containing protein (VCP) expression and decreased cleaved caspase-12 expression in denervated muscles. PMID: 20871144
    14. both the PERK/eIF2 alpha/ATF4 ISR and activation of caspase-12 may be involved in apoptosis of spinal cord astrocytes induced by OGSD/restoration. PMID: 20444431
    15. Spinal cord injury induced greater spinal cord caspase 12 expression in diabetic vs non diabetic rats. PMID: 19215662
    16. Na/Ca exchanger overexpression, by depleting ER Ca(2+) stores, triggers the activation of caspase-12 and increases apoptotic cell death PMID: 12031969
    17. Immunohistochemical analysis reveals diffuse positive immunostaining of caspase-12 throughout the striatum and cerebral cortex in animals that undergo ischemia, with more intense caspase-12 staining in post-ischemic striatum than in post-ischemic cortex. PMID: 12598725
    18. caspase-12 induction was noted in neurons in both the cortex and hippocampus as well as in astrocytes at the contusion site after traumatic brain injury PMID: 14675152
    19. a striking approximately 350% increase in the expression of procaspase-12 (caspase located at the sarcoplasmic reticulum) PMID: 14732288
    20. inactivation of caspase-12 via the NGF-mediated PI3-K signaling pathway leads to inactivation of the caspase cascade including caspase-3 and -9 PMID: 15113843
    21. Doxorubicin treatment in vivo activates casp12-mediated cardiac apoptosis in both male and female rats. PMID: 15556633
    22. Increased ER stress-induced apoptosis and activation of caspase-12 were observed in IRPTCs with albumin overload and kidneys of experimental proteinuric rats. PMID: 16955111
    23. These results suggest that TM elicits subregion-specific neuronal toxicity in OHC and that the vulnerability to TM-induced toxicity is at least partly dependent on the expression level of endogenous procaspase-12 in each area of the hippocampus. PMID: 18280615
    24. proteolytic activity of caspase-12 is confined to its own proenzyme PMID: 18332441

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  • 蛋白家族：
    Peptidase C14A family
  • 数据库链接：

    KEGG: rno:156117

    STRING: 10116.ENSRNOP00000010244

    UniGene: Rn.81078

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