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  4. Recombinant Rat Cystic fibrosis transmembrane conductance regulator (Cftr), partial

Recombinant Rat Cystic fibrosis transmembrane conductance regulator (Cftr), partial

  • 中文名称：
    Recombinant Rat Cystic fibrosis transmembrane conductance regulator(Cftr) ,partial
  • 货号：
    CSB-YP005292RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Cystic fibrosis transmembrane conductance regulator(Cftr) ,partial
  • 货号：
    CSB-EP005292RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Cystic fibrosis transmembrane conductance regulator(Cftr) ,partial
  • 货号：
    CSB-EP005292RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Cystic fibrosis transmembrane conductance regulator(Cftr) ,partial
  • 货号：
    CSB-BP005292RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Cystic fibrosis transmembrane conductance regulator(Cftr) ,partial
  • 货号：
    CSB-MP005292RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cftr
  • Uniprot No.：
    P34158
  • 别名：
    Cftr; Abcc7Cystic fibrosis transmembrane conductance regulator; CFTR; ATP-binding cassette sub-family C member 7; Channel conductance-controlling ATPase; EC 5.6.1.6; cAMP-dependent chloride channel
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the...显示更多
  • 基因功能参考文献：
    1. Based on the nuclear localization of CFTR in rat testicles we suggest that, in addition to its role as an ion channel, CFTR may have an independent role in gene regulation within the nuclei. PMID: 29453757
    2. dexa induces a rapid stimulation of CFTR activity which depends on PI3K/AKT signaling in airway epithelial cells. Glucocorticoids might thus represent, in addition to their immunomodulatory actions, a therapeutic strategy to rapidly increase airway fluid secretion. PMID: 28825630
    3. findings appear to be intrinsic to the CFTR deficient state and independent of significant clinical confounders, providing substantive evidence for the importance of CFTR on maintinaing normal bone growth PMID: 29190650
    4. Increased levels of CFTR, adenylate cyclase and cAMP in cervix of rats treated with sex hormones and genistein could affect the cervical secretory function, influencing female reproductive processes. PMID: 26529183
    5. increased abundance of CFTR, AC, and cAMP under estrogen influence could account for the increased fluid accumulation within the cervical lumen. PMID: 26018621
    6. CFTR Cl- channel is a molecular target of natural compounds EGCG and ECG. PMID: 25747701
    7. CFTR is involved in water homeostasis of the seminiferous tubular secretion. PMID: 25270793
    8. mRNA of the CFTR was expressed in the endolymphatic sac. Immunohistochemical analysis showed the expression of the CFTR on apical side of the endolymphatic sac epithelia and co-localization with the ENaC. PMID: 24598307
    9. CFTR may modulate oxidative stress-related basilar vascular smooth muscle cells apoptosis through the cAMP- and mitochondria-dependent pathway and regulating endogenous antioxidant defense system. PMID: 24999019
    10. Young CFTR-/- rats exhibited histological abnormalities in the ileum and increased intracellular mucus in the proximal nasal septa. PMID: 24608905
    11. Changes in CFTR protein manifestation in the hepatic ductal structures and renal tubules in experimental pregnancy cholestasis could aggravate the disease. PMID: 24770751
    12. Exocrine pancreas with CFTRDeltaF508 mutation or endocrine CFTR-inhibited cells present susceptibility to P.Aeruginosa lipopolysaccharides . During recurrent infections exocrine Microparticles may contribute to endocrine cell dysfunction via NF-kappaB pathways. PMID: 24095207
    13. The co-immunoprecipitation experiments showed a direct interaction between AQP4 and CFTR in cultured rat Sertoli cells. PMID: 24657265
    14. Alveolar Cl(-) and fluid secretion are triggered by ENaC inhibition and mediated by NKCC and CFTR. PMID: 23645634
    15. Activation of endogenous myocardial CFTR upon early reperfusion is involved in protection against necrotic myocardial injury induced by ischemia/reperfusion in vivo and in vitro. PMID: 23221371
    16. cAMP/protein kinase A activates cystic fibrosis transmembrane conductance regulator for ATP release from rat skeletal muscle during low pH or contractions. PMID: 23226244
    17. Progesterone inhibits CFTR and SLC26A6 proteins and mRNA expression while oestrogen (E) causes vice versa. PMID: 23226939
    18. study highlighted important role of CFTR in negatively regulating COX-2/PGE2 in the testis and its involvement in regulating testicular junctional complexes and blood-testis barrier; decreased expression of CFTR in cryptorchidism results in activation of NF-kappaB, overexpression of COX-2 and excessive PGE2 production PMID: 22777528
    19. Ivacaftor potentiated multiple mutant CFTR forms with defects in CFTR channel gating. These included the G551D, G178R, S549N, S549R, G551S, G970R, G1244E, S1251N, S1255P and G1349D CFTR gating mutations. PMID: 22293084
    20. Fecal impaction from anal ligation induces early compensatory up-regulation of CFTR, altering function from net absorption to net secretion in the mid and distal colon. PMID: 22424353
    21. The CFTR channel plays a complementary role in the effects of the chloride channels opened by glycine during rapid-eye-movement (REM) sleep. PMID: 21185916
    22. CFTR operates together with solute carrier NKCC1 to produce depolarizing GABA/glycine mediated synaptic events. PMID: 21308994
    23. Defective CFTR-dependent CREB activation results in impaired spermatogenesis and azoospermia. PMID: 21625623
    24. CFTR (cystic fibrosis transmembrane conductance regulator) plays an important role in ATP efflux from skeletal muscle cells during acidosis. PMID: 20819945
    25. CFTR and its mediated HCO(3)(-) secretion may be up-regulated in prostatitis as a host defense mechanism PMID: 21151921
    26. The Cystic Fibrosis Transmembrane Conductance Regulators by siRNA-mediated silencing are modulators of plasma membrane H+-ATPase by chloride channels in proximal tubule. PMID: 21063094
    27. analysis of modification of CFTR activity and genistein binding by cytosolic pH PMID: 20974851
    28. syntaxin 3 interacts with CFTR in vivo. PMID: 20844248
    29. alpha-AP-2 has a role in directing myosin VI-dependent endocytosis of CFTR; myosin VI is involved in membrane invagination and coated pit formation in enterocytes PMID: 20351096
    30. Reciprocal protein kinase A regulatory interactions between cystic fibrosis transmembrane conductance regulator and Na+/H+ exchanger isoform 3 in a renal polarized epithelial cell model. PMID: 11937500
    31. mutations in CFTR nucleotide binding domain region rescue the CFTRDeltaF508 defect PMID: 12110684
    32. Contribution of CFTR to vascular tone; the alpha-adrenergic agonist norepinephrine, CFTR activators produced a concentration-dependent relaxation. PMID: 15020588
    33. 50-250 of functional CFTR Cl(-) channels occur in adult alveolar cells and could contribute to alveolar liquid homeostasis. PMID: 15107294
    34. In conclusion, there is an increased expression of CFTR in the liver after common bile duct ligation PMID: 15605366
    35. In the lung CFTR is part of a developmental cascade for normal secretory cell differentiation. Absence of CFTR results in a constitutive inflammatory process that is involved in some aspects of cystic fibrosis pathophysiology. PMID: 15694001
    36. cAMP and cGMP-dependent phosphorylation regulates fluid secretion and CFTR trafficking to the surface of enterocytes in rat jejunum PMID: 15872007
    37. Cystic fibrosis transmembrane conductance regulator (CFTR) is involved in the pathogenesis of ovarian hyperstimulation syndrome. PMID: 16051669
    38. CFTR associated mutants G551D and G1349D have different sensitivity to CFTR potentiators PMID: 16311240
    39. Immunohistochemical localization of proteins known to be important in HCO(3) (-) secretion was investigated in the rat common bile duct. PMID: 16575514
    40. CFTR opening is involved in the vasorelaxant action of genistein, and cAMP-dependent CFTR phosphorylation and chloride entry via the NKCC1 cotransporter are required for genistein action PMID: 16859673
    41. we report that WNK1 co-localizes with CFTR protein in pulmonary epithelial cells. PMID: 17194447
    42. a cross-talk between CFTR and a variety of gap junction channels. Cytoskeletal scaffolding proteins and/or other intermediate cytoplasmic proteins are likely to play a role in CFTR-connexins interaction. PMID: 17546509
    43. Cyclic AMP-induced ductular bicarbonate secretion depends on an autocrine signaling pathway that involves CFTR, apical release of ATP, stimulation of apical nucleotide receptors, and then activation of apical, type III InsP3Rs. PMID: 17916355
    44. In situ immunocytochemistry studies with two monoclonal antibodies recognizing different CFTR epitopes indicated that CFTR expression occurs mainly in glucagon-secreting alpha-cells. PMID: 18040894
    45. CFTR is an important regulator of AQP9 and the interaction between AQP9, NHERF1, and CFTR may facilitate the activation of AQP9 by cAMP. PMID: 18055461
    46. A2A receptors open Cl- channels in pancreatic ducts cells with functional cystic fibrosis transmembrane regulator (CFTR). PMID: 18057956
    47. Results show that secretory markers such as CFTR, CC10, and CC26 are present in taste cells of rat circumvallate papillae, and their immunoreactivity is expressed, to a different extent, in subsets of taste cells that express alpha-gustducin. PMID: 18156603
    48. muscarinic stimulation-induced Cl(-) reabsorption occurs through basal CFTR activity and that this is regulated by P2Y(2) receptors PMID: 18337312
    49. Furthermore, CFTR inhibition prevented CO(2)-induced cellular acidification reversed by S3226. PMID: 18420826
    50. This study found widespread and abundant the expression of CFTR protein and its mRNA in the ganglion cells of the rat hearts. PMID: 18584958

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  • 亚细胞定位：
    Apical cell membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus.
  • 蛋白家族：
    ABC transporter superfamily, ABCC family, CFTR transporter (TC 3.A.1.202) subfamily
  • 组织特异性：
    Detected in epithelial cells in nasopharynx, submandibular gland, pancreas and ileum (at protein level). Expressed in the epididymis. In the caput section of the epididymis, expressed uniformly on both the luminal and basolateral sides of the ducts and on
  • 数据库链接：

    KEGG: rno:24255

    STRING: 10116.ENSRNOP00000010981

    UniGene: Rn.124539

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