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  4. Recombinant Rat Dynamin-2 (Dnm2), partial

Recombinant Rat Dynamin-2 (Dnm2), partial

  • 中文名称：
    大鼠Dnm2重组蛋白
  • 货号：
    CSB-YP007079RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Dnm2重组蛋白
  • 货号：
    CSB-EP007079RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Dnm2重组蛋白
  • 货号：
    CSB-EP007079RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Dnm2重组蛋白
  • 货号：
    CSB-BP007079RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Dnm2重组蛋白
  • 货号：
    CSB-MP007079RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Dnm2
  • Uniprot No.：
    P39052
  • 别名：
    Dnm2; Dyn2Dynamin-2; EC 3.6.5.5
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones. Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis. Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane.
  • 基因功能参考文献：
    1. Study is the first to show the association of dynamin Charcot-Marie-Tooth disease mutations with aberrant actin dynamics and lamellipodia, which may contribute to defective endocytosis and myelination in Schwann cells in Charcot-Marie-Tooth disease. PMID: 27328317
    2. Reduction in dynamin-2 is implicated in ischaemic cardiac arrhythmias. PMID: 25092467
    3. dynamin2 orchestrates the global actin cytoskeleton PMID: 24710573
    4. Disruption of the DNM2-dependent retrograde trafficking of NHE1 contributes to cardiomyocyte apoptosis. PMID: 23837875
    5. dynamin isoforms select appropriate vesicle reuse pathways associated with specific neuronal firing patterns PMID: 23687302
    6. This study suggested that myelination is strictly dependent on Dnm2 and clathrin-mediated endocytosis function. PMID: 22451505
    7. ITSN-1s, via its SH3A domain has the unique ability to regulate dyn2 assembly-disassembly and function during endocytosis PMID: 21129155
    8. Dynamin 2 and cortactin co-localize in advancing growth cones of embryonic hippocampal neurons. PMID: 21210813
    9. Dynamin 2 is primarily tetrameric throughout the entire cell membrane. PMID: 21281565
    10. These findings support the view that endophilin-dynamin interactions play an important role in endocytosis. PMID: 21281588
    11. Formation of abnormally large and stable complexes of these dynamin mutants in vivo contributes to their role in centronuclear myopathies pathogenesis PMID: 20529869
    12. Role of the proline-rich domain of dynamin-2 and its interactions with Src homology 3 domains during endocytosis of the AT1 angiotensin receptor PMID: 11925437
    13. Localization of dynamin 2 in rat seminiferous tubules during the spermatogenic cycle. PMID: 12199526
    14. there is a distinct signaling network originating from the dopamine receptor that regulates the state of dynamin-2 phosphorylation and that promotes its location at the site of Na(+),K(+)-ATPase endocytosis PMID: 12205083
    15. The dynamins comprise a large family of mechanoenzymes known to participate in membrane modeling events. All three conventional dynamin genes (Dnm1, Dnm2, Dnm3) are expressed in mammalian brain and produce more than 27 different dynamin proteins. PMID: 12646135
    16. dynamin plays role in Rac trafficking to allow for lamellipodia formation and cell spreading PMID: 14617821
    17. Src-mediated phosphorylation of dynamin-2 is an essential requirement for scission of caveolae and the resultant transendothelial transport of albumin PMID: 15007081
    18. the first demonstration of the co-expression of all three dynamin isoforms in a non-tumor cell PMID: 15126636
    19. differential binding of SH3 domain-containing proteins to dynamin-1 and -2 may contribute to the distinct functions performed by these isoforms PMID: 15834155
    20. Data show that swapping the highly homologous GTPase domain of dynamin-2 into dynamin-1 is sufficient to confer caspase-3 activation. PMID: 16938290
    21. Dnm2 mediates fluid-phase micropinocytosis in epithelial cells. PMID: 18003703
    22. cooperative function of dynamin 2 and amphiphysin 1 in phosphatidylserine-dependent phagocytosis is strongly suggested in sertoli cells PMID: 19122684
    23. Dynamin2 GTPase and cortactin remodel actin filaments. PMID: 19605363

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Cell junction. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Midbody. Membrane, clathrin-coated pit. Cell projection, phagocytic cup. Cytoplasmic vesicle, phagosome membrane; Peripheral membrane protein.; [Isoform 2]: Cytoplasmic vesicle, clathrin-coated vesicle. Membrane, clathrin-coated pit.; [Isoform 4]: Cell membrane.
  • 蛋白家族：
    TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family
  • 组织特异性：
    Ubiquitously expressed. Brain expression is restricted to glial cells and fibroblasts. Highest levels in the testis.
  • 数据库链接：

    KEGG: rno:25751

    STRING: 10116.ENSRNOP00000060296

    UniGene: Rn.11231

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