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  4. Recombinant Rat Fatty acid-binding protein, liver (Fabp1)

Recombinant Rat Fatty acid-binding protein, liver (Fabp1)

  • 中文名称：
    大鼠Fabp1重组蛋白
  • 货号：
    CSB-YP007940RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Fabp1重组蛋白
  • 货号：
    CSB-EP007940RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Fabp1重组蛋白
  • 货号：
    CSB-EP007940RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Fabp1重组蛋白
  • 货号：
    CSB-BP007940RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Fabp1重组蛋白
  • 货号：
    CSB-MP007940RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Fabp1
  • Uniprot No.：
    P02692
  • 别名：
    Fabp1Fatty acid-binding protein; liver; Fatty acid-binding protein 1; Liver-type fatty acid-binding protein; L-FABP; Squalene- and sterol-carrier protein; SCP; Z-protein; p14
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-127
  • 氨基酸序列
    MNFSGKYQVQ SQENFEPFMK AMGLPEDLIQ KGKDIKGVSE IVHEGKKVKL TITYGSKVIH NEFTLGEECE LETMTGEKVK AVVKMEGDNK MVTTFKGIKS VTEFNGDTIT NTMTLGDIVY KRVSKRI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes. Binds cholesterol. Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
  • 基因功能参考文献：
    1. Studies show that despite overall tertiary structure similarity, the hFABP1 differs significantly from rat FABP1 in secondary structure, much larger ligand binding cavity, and affinities/specificities for some ligands. Moreover, while both mouse and hFABP1 mediate ligand induction of PPARA, they differ markedly in genes induced. PMID: 27117865
    2. L-FABP structurally and functionally interacts with HNF4alpha. PMID: 24140341
    3. These results provide strong support for monoacylglycerol as a physiological ligand for LFABP and further suggest that LFABP functions in the efficient intracellular transport of MG PMID: 23658011
    4. Phosphorylation of Sar1b protein releases liver fatty acid-binding protein from multiprotein complex in intestinal cytosol enabling it to bind to endoplasmic reticulum (ER) and bud the pre-chylomicron transport vesicle. PMID: 22303004
    5. NMR study of liver fatty acid-binding protein PMID: 21226535
    6. Clofibrate enhanced L-FABP gene transcription and mRNA stability, thus affecting L-FABP expression and ultimately cellular antioxidant activity. PMID: 21102658
    7. a direct role of glucose in facilitating L-FABP-mediated uptake and distribution of lipidic ligands to the nucleus for regulation of PPARalpha transcriptional activity PMID: 20628144
    8. Data show that niacin therapyreduced renal tissue lipids, CD36, ChREBP, LXR, ABCA-1, ABCG-1, and SR-B1 abundance and raised PPAR-alpha and L-FABP. PMID: 19878707
    9. The results support the concept that ligands with a bulky anionic head group bind at site 2 of liver fatty acid binding protein where solvent exposure allows the accommodation of their bulky anionic group. PMID: 12479568
    10. The helical domain of liver FABP is able to convert the fatty acid transfer properties of intestinal FABP to those of liver FABP. These short (six to eight residues) helical segments can now be appreciated as novel motifs. PMID: 15035630
    11. time course of changes in L-FABP mRNA and protein levels during liver regeneration following partial hepatectomy PMID: 15532708
    12. The localization and possible function of Fabp1 in liver peroxisomes is described and discussed. PMID: 16262600
    13. These results are consistent with tethering of one GATA factor to the Fabp1 promoter through interaction with a second GATA factor to produce increased target gene activation. PMID: 16603485
    14. reducing both L-FABP and microsomal triglyceride transfer protein is an effective means to reduce very low density lipoprotein secretion without causing hepatic steatosis PMID: 16950764
    15. L-FABP can select cargo for and bud PCTV from intestinal ER membranes PMID: 17449472
    16. Esterification patterns of fatty acids L-FABP-bound or free into nuclear lipids were the same whereas in the nuclear matrix, L-FABP could play an important role in the mobilization of 20:4n-6 into specific sites of utilization such as the PtdIns pools. PMID: 17551764
    17. Solution-state molecular structure of apo and oleate-liganded liver fatty acid-binding protein. PMID: 17927211

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Calycin superfamily, Fatty-acid binding protein (FABP) family
  • 数据库链接：

    KEGG: rno:24360

    STRING: 10116.ENSRNOP00000008841

    UniGene: Rn.36412

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