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  4. Recombinant Rat High mobility group protein B1 (Hmgb1)

Recombinant Rat High mobility group protein B1 (Hmgb1)

  • 中文名称：
    大鼠Hmgb1重组蛋白
  • 货号：
    CSB-YP010553RAa1
  • 规格：
    ￥2616
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    Hmgb1
  • Uniprot No.：
    P63159
  • 别名：
    Hmgb1; Hmg-1; Hmg1; High mobility group protein B1; Amphoterin; Heparin-binding protein p30; High mobility group protein 1; HMG-1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    Yeast
  • 分子量：
    27.4 kDa
  • 表达区域：
    2-215aa
  • 氨基酸序列
    GKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-tagged and C-terminal Myc-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    25-35 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

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靶点详情

  • 功能：
    Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplas...显示更多
  • 基因功能参考文献：
    1. miR-381could inhibit neuropathic pain development through targeting HMGB1 and CXCR4. PMID: 30142543
    2. Ketamine delays the progression of oxidative and damaged cataract by regulating HMGB-1/NF-kappaB expression, inhibiting TNF-alpha, IL-1beta, and apoptosis, and promoting cell proliferation. PMID: 30111205
    3. High HMGB1 expression is associated with sepsis-induced kidney injury. PMID: 30130540
    4. Chronic unpredictable stress (CUS) promotes significant morphological changes and causes robust upregulation of HMGB1 messenger RNA in enriched hippocampal microglia and robust and persistent upregulation of RAGE messenger RNA. CUS increased surface expression of RAGE protein on hippocampal microglia and anhedonic behavior. HMGB1 infusion into the hippocampus was sufficient to cause anhedonic behavior. PMID: 28882317
    5. Autophagy was the leading cause of adriamycin-induced cardiotoxicity, and HMGB1 played a vital role in the process of up-regulating autophagy. PMID: 29715512
    6. concluded that in mild oxidative stress, HMGB1 is cytoprotective, whereas in intense oxidative stress, HMGB1 actions promote cell death and liver damage PMID: 28695466
    7. Findings suggested that overexpression of Pgp during seizures may be regulated by HMGB1 via the RAGE/NFkappaB signaling pathway. PMID: 28627626
    8. Up-regulation of miR-129-5p might suppress the HMGB1-RAGE signaling pathway to restrain the revascularization of rats with ICH. PMID: 28645008
    9. Investigation identified that HMGB1 promotes neurovascular recovery via Rage and may act in the oxidized state in the late stage of SAH. PMID: 28606778
    10. our findings demonstrated an elevation of HMGB1 in pulmonary fibrosis; HMGB1 promoted the increment of proliferation, extracellular matrix production and aerobic glycolysis of embryonic lung fibroblast PMID: 28571757
    11. the HMGB1-TLR9 signaling pathway may be involved in the pathogenesis of diabetic retinopathy. PMID: 28647749
    12. In conclusion, the results suggested that GL attenuated TBI by inhibiting M1 phenotype while inducing M2 phenotype activation of microglia/macrophages, at least partly through inhibiting HMGB1. Also, targeting HMGB1 to modulate the microglia/macrophage polarization should be one potential therapeutic approach for TBI. PMID: 29448108
    13. The neuroimmune activation induced by chronic alcohol may involve the danger signaling molecule high mobility group box 1 (HMGB1), which binds Toll-like receptors 4 (TLR4). PMID: 26857094
    14. Glycyrrhizin may protect rats against sepsis by blocking the interaction of HMGB1 with cell surface receptors and HMGB1-mediated inflammatory responses PMID: 28484719
    15. These results suggest that HMGB1-modulated TLR5 signaling is responsible for pain hypersensitivity. PMID: 27760316
    16. HMGB1 modulation may lengthen the therapeutic window for stroke treatments. PMID: 27544687
    17. this study provides the first evidence showing that HMGB1 plays a critical role in regulating VSMC phenotypic modulation, suggesting that HMGB1 may be a potential therapeutic target to prevent vascular occlusive diseases. PMID: 27579780
    18. HMGB1 and its signaling transduction have critical roles in the pathogenesis of septic brain injury. PMID: 27889435
    19. Anti-proliferative effect of terameprocol in pulmonary hypertension seems to be explained, at least in part, by the down-regulation of the transcription factor HMGB1. PMID: 28036116
    20. Oxidative stress during epileptogenesis was associated with de novo brain and blood generation of disulfide high mobility group box 1 (HMGB1), a neuroinflammatory molecule implicated in seizure mechanisms. PMID: 28575153
    21. Results suggest that electroacupuncture pretreatment could alleviate spinal cord ischemia-reperfusion injury. These protective effects of electroacupuncture pretreatment may relate to the block of pro-inflammatory cytokines release and attenuation of apoptosis via inhibition of HMGB1 release in a LXA4 receptor-dependent manner. PMID: 28089662
    22. Further, HMGB1 antagonism prevented prolonged infection-induced neuroinflammatory and sickness responses in aged rats. Overall, blocking HMGB1 "desensitized" microglia in the aged brain, thereby preventing pathological infection-elicited neuroinflammatory responses. PMID: 27466339
    23. HMGB1 plays a key pathophysiological role in the onset of epilepsy-related hyperexcitability. PMID: 28222432
    24. Suggest that HMGB1 may not be a major player in cerebral vascular dilating dysfunction after subarachnoid hemorrhage. PMID: 27997923
    25. study suggests that HMGB1 can positively influence the survival of spiral ganglion neurons following ototoxic exposure via both its extracellular and intranuclear functions PMID: 27704212
    26. binding proteins of cytoplasmic HMGB1 during hepatic Ischemia/reperfusion injury were identified. PMID: 28275217
    27. These findings suggested that the cytoplasmic translocation of HMGB1 may be caused by diabetes and high glucose in retinal pericytes, and that the pathogenic role of HMGB1 may be dependent on the expression of RAGE and activation of NFkappaB. PMID: 27599553
    28. The present study confirmed that Cerebral ischemic postconditioning inhibited autophagy and HMGB1 secretion, autophagy inhibition induced a decrease in HMGB1 secretion, and HMGB1 secretion attenuation caused autophagy inhibition in return, as demonstrated by immunofluorescence and western blot analyses. PMID: 27666823
    29. in an ANP model, HMGB1 was initially increased in the nuclei to initiate autophagy. Subsequently, it moved into the cytoplasm, where it interacted with Beclin 1 to enhance autophagy, and HMGB1 was released into the blood, leading to the deterioration of ANP. PMID: 27878276
    30. Regnase-1 can be induced by HMGB1 in microglia and negatively regulates HMGB1-mediated neuroinflammation and neuronal toxicity PMID: 27044405
    31. HMGB1 contributes significantly to cardiac arrest-induced brain dysfunction PMID: 27363991
    32. the present study suggested that upregulation of miR451 could protect against A/Rinduced cardiomyocyte injury by inhibiting HMGB1 expression. PMID: 27121079
    33. Hypoxia enhanced the expression of HMGB1 in bone marrow mesenchymal stem cells with influences on apoptosis and adhesion. PMID: 28050559
    34. Bone marrow stromal cell-treated type 2 diabetic rats inhibited inflammation and improved functional outcome after stroke; data suggest that BMSCs-induced reduction of HMGB1 and RAGE in type 2 diabetic-middle cerebral artery occlusion rats contributed to attenuated inflammatory response in the ischemic brain, which may lead to the beneficial effects of bone marrow stromal cells treatment. PMID: 26946264
    35. Hemorrhagic shock elicited significant increases in the mRNA and protein expressions of HMGB1 and RAGE in the kidney. PMID: 26513053
    36. Results suggest that high mobility group box-1 mediates, in part, the neuroinflammatory effects of methamphetamine and thus may alert central nervous system innate immune cells to the toxic effects of methamphetamine. PMID: 26254235
    37. ketamine protects rats against HMGB1-RAGE activation in a rat model of sepsis-induced acute lung injury PMID: 26945830
    38. Extracellular high-mobility group box-1 (HMGB1) was identified as the likely endogenous regulator of IL1 expression after injury PMID: 26899371
    39. Polygonum cuspidatum extract prevents diabetes-induced vascular permeability by inhibiting HMGB1/RAGE/NFkappaB activation in diabetic retinas. PMID: 26950148
    40. bone marrow mesenchymal stem cell transplantation improves liver function/pathology in acute liver failure rats and decreases the serum/liver HMGB1. PMID: 26884873
    41. HMGB1 is increasingly expressed in parallel to the development of cerebral vasospasm in this rat experimental model of subarachnoid hemorrhage PMID: 26765765
    42. These findings indicate that administration of 1alpha,25(OH)2D3 might provide a favorable microenvironment for orthodontic tooth movement by downregulating expression of HMGB1 in periodontal ligament cells. PMID: 26956363
    43. These results suggest that intravenous pre-treatment with HMGB1 may exert its cardioprotective effects via the upregulation of the myocardial expression of HIF-1alpha, which may be regulated by the PI3K/Akt signaling pathway, in rats following acute myocardial I/R. PMID: 26648172
    44. Results indicate that HMGB1 is a critical regulator of autophagy and HMGB1-induced autophagy plays a protective role in spinal neurons against injuries PMID: 26705737
    45. determined that the plasma levels and hepatic tissue levels of HMGB1 were significant increased in acute liver failure PMID: 26722388
    46. Increased levels of PKR and HMGB1 in synovium or blood appear to be involved in the occurrence and development ofrheumatoid arthritis (RA )in a rat model. Selective inhibition of PKR improves the symptoms of RA perhaps by inhibiting the release of HMGB1 PMID: 26782432
    47. HMGB1 or Beclin1 upregulate alpha-synuclein degradation, ameliorating alpha-synuclein-mediated autophagy reduction in PC12 cells. PMID: 26822891
    48. The data indicate that HMGB1 accumulates in renal tissue and enters the urine, and the interaction between HMGB1 and TLR4 turns renal tubular epithelial cells into inflammatory promoters during sepsis. PMID: 26312770
    49. Overexpression of miR141 alleviates neuropathic pain development via targeting and inhibiting HMGB1. PMID: 26398163
    50. findings demonstrate an important role of HMGB1 in mediating inflammasome activation in the development of liver injury PMID: 25931416

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Secreted. Chromosome. Cell membrane; Peripheral membrane protein; Extracellular side. Endosome. Endoplasmic reticulum-Golgi intermediate compartment.
  • 蛋白家族：
    HMGB family
  • 数据库链接：

    KEGG: rno:25459

    STRING: 10116.ENSRNOP00000040874

    UniGene: Rn.144565

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