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  4. Recombinant Rat Insulin receptor substrate 1 (Irs1), partial

Recombinant Rat Insulin receptor substrate 1 (Irs1), partial

  • 中文名称：
    大鼠Irs1重组蛋白
  • 货号：
    CSB-YP011829RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Irs1重组蛋白
  • 货号：
    CSB-EP011829RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Irs1重组蛋白
  • 货号：
    CSB-EP011829RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Irs1重组蛋白
  • 货号：
    CSB-BP011829RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Irs1重组蛋白
  • 货号：
    CSB-MP011829RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Irs1
  • Uniprot No.：
    P35570
  • 别名：
    Irs1; Irs-1; Insulin receptor substrate 1; IRS-1; pp185
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.
  • 基因功能参考文献：
    1. EAF exerted its effect by modulating insulin signalling, potentially via IRS1/AKT activation. PMID: 29248832
    2. Treatment by tanshinone I lowered the levels of IL-6 and TNF-alpha, decreased nuclear translocation of NF-kappaB as well as phosphorylation of Ser307 in IRS-1. PMID: 28651236
    3. This study determined if dietary restriction (DR) protects against hypoxic-ischemia (HI) in the neonatal brain via insulin receptor substrate-1 (IRS-1)/Akt pathway-mediated downregulation of p53 in the neurovascular unit. PMID: 26111627
    4. the increased IRS1 expression may mediate the insulin-sensitizing effects of sodium butyrate. PMID: 27619406
    5. results suggest that upregulation of the INSR on T cells following activation is required for efficient adaptive immunity PMID: 28115529
    6. The results suggest that high glucose compromises the insulin signaling pathway in the glomerulus, promoting a proapoptotic environment, with a possible critical step for this malfunction lying at the level of IRS-1 phosphorylation. PMID: 27434075
    7. Under insulin stimulation, and in spite of the less activated mTOR function in high altitude rats, low altitude rats had higher glycogen content and reduced levels of gluconeogenic enzymes with a more enhanced insulin signaling, mainly due to higher levels of phosphorylated IRS1. PMID: 28084108
    8. Chronic periapical lesions are associated with decreased insulin signaling - evaluated according to insulin receptor substrate (pp185-insulin receptor substrate 1 [IRS-1]/insulin receptor substrate 2 [IRS-2]) tyrosine phosphorylation status, IRS-1 serine phosphorylation status, and IRS-1 and IRS-2 content - in the skeletal muscle of rats PMID: 26027876
    9. Data suggest FSH and IGF1 (insulin-like growth factor-1) PI3K signaling pathways in granulosa cells converge at IRS1 (insulin receptor substrate 1), requiring PKA (cyclic AMP-dependent protein kinase) and PP1 (protein phosphatase 1) to regulate IRS1. PMID: 26702053
    10. IRS-2 was one of the targets of miR-126. MiR-126 inhibited the beta-cell proliferation through IRS-2 instead of IRS-1. MiR-126 may take part in the glucose homeostasis both through its target IRS-2 and IRS-1. PMID: 26919700
    11. These results suggest that the GSK-3beta-IRS1 pathway may play a significant role in Wnt-mediated central blood pressure regulation. PMID: 25883115
    12. overexpression of IRS1 stimulated osteoblast proliferation, as evidenced by an increase in the number of cells in the S phase compared to controls. PMID: 25372512
    13. Insulin receptor substrate-1 (IRS-1) is recruited to interact with the IR-catalyzed phospho-tyrosine cav-2, which facilitates IRS-1 association with and activation by IR to initiate IRS-1-mediated downstream signaling. PMID: 25667086
    14. Serine 307 on IRS-1 is indispensable for SOCS3 and TNF-alpha signaling in the retinal neuroglial cell line. PMID: 25352752
    15. insulin-resistant status of rats induced by dexamethasone administration have PKB and IRS-1 activity attenuated in epididymal fat without increases in the phosphorylation of the proinflammatory signals JNK and IKKbeta PMID: 25268311
    16. Daata indicate that insulin receptor substrate 1 IRS1 Ser(P)/Thr(P) is an integrated response to insulin stimulation and metabolic stress, which associates with reduced Tyr(P)(Irs1). PMID: 24652289
    17. Suggest that oleanolic acid supplement ameliorates fructose-induced adipose tissue insulin resistance in rats via the IRS-1/phosphatidylinositol 3-kinase/Akt pathway. PMID: 24704288
    18. Dietary high-fructose corn syrup causes vascular insulin resistance and endothelial dysfunction through attenuating IRS-1 and eNOS expressions as well as increasing iNOS in rats. PMID: 23872130
    19. Data indicate that hyperglycemia seems to inhibit the interaction between insulin receptor substrate (IRS1) and insulin receptor (IRbeta). PMID: 24462861
    20. Taken together, our findings demonstrate that activation of the ERK pathway in sensory neurons as a consequence of mTORC1 inhibition leads to the development of pain. PMID: 23607966
    21. Nexilin, a cardiomyopathy-associated F-actin binding protein, binds and regulates IRS1 signaling in skeletal muscle cells. PMID: 23383252
    22. Data suggest that down-regulation of insulin signaling pathway (Irs1, Irs2, and insulin-like growth factor-1) in type II diabetic osteoporosis model occurs either sooner or more dramatically in bone as compared to liver, kidney or skeletal muscle. PMID: 22820932
    23. Induction of streptozotocin diabetes resulted in decreased level of GLP-1R and increased levels of IRS-1 and Raf-1 in the liver. PMID: 22983684
    24. phosphorylation of IRS1 is governed by a small plasma membrane-localized pool of IR with an early peak, or (ii) inhibition of the IR-catalyzed phosphorylation of IRS1 by negative feedback PMID: 22248283
    25. Adiponectin may decrease tyrosine phosphorylation of IRS-1 via the IKK/NFkappaB pathway and inhibit insulin signaling pathway in the liver. PMID: 21602124
    26. Increased IKKalpha/beta and JNK serine phosphorylation may contribute to increasing IRS-1 serine phosphorylation, while concurrent co-localization of SOCS-3 with both IR-beta and IRS-1 may prevent IRS-1 from interacting with IR-beta; these 2 mechanisms may independently contribute to impairing insulin-stimulated PI3-K activation in the skeletal muscle of the obese Zucker rat. PMID: 22982470
    27. the importance of IRS-1 in beta-adrenergic receptor signaling in the prevention of cell death in retinal Muller cells is suggested PMID: 22328823
    28. The insulin resistance in L6 cells induced by TNF-alpha might be attenuated by acetyl-L-carnitine via decreasing the expression of Ser307 phosphorylation of IRS-1. PMID: 20459025
    29. These findings suggest that improvements in glucose tolerance and insulin resistance following Roux-en-Y gastric bypass surgery are associated with upregulation of IRS-1. PMID: 22001674
    30. Foxo1 protein was excluded from the nuclei in L6-mIRS1 cells, whereas Foxo1 was localized in the nuclei in control L6 cells during induction of differentiation. PMID: 21991327
    31. We conclude that phosphorylation of Ser307, Ser302, and Ser632 of IRS-1 is not involved in ANG II-mediated IRS-1 degradation PMID: 21900690
    32. sex steroid deficiency induces impaired glucose oxidation in insulin responsive tissues, which is mediated through reduced IR expression, and increased IRS-1 serine phosphorylation PMID: 21301931
    33. Our findings suggest an interaction between vitamin D(3) and muscarinic M3 receptors in regulating insulin secretion from pancreas. PMID: 20655720
    34. Protein, but not mRNA levels of IRS1, was decreased only in the glomeruli of streptozotocin-diabetic rats likely due to increased ubiquitination. PMID: 21228767
    35. resistin induces cardiac hypertrophy and myocardial insulin resistance, possibly via the AMPK/mTOR/p70(S6K) and apoptosis signal-regulating kinase 1/JNK/IRS1 pathways. PMID: 21478152
    36. Adiponectin receptors and IRS1 might be crucially important regulators for the synthesis and oxidation of fatty acids in the liver of Nonalcoholic steatohepatitis PMID: 20846698
    37. iNOS-mediated tyrosine nitration of IRS-1 is a key mechanism of skeletal muscle insulin resistance in endotoxemia PMID: 21206533
    38. Over-expression of NYGGF4 inhibits glucose transport in skeletal myotubes by blocking the IRS1/PI3K/AKT insulin pathway PMID: 21185755
    39. Chronic ethanol intake could induce insulin resistance and down-regulated the expression of IR, IRS-land PI-3K mRNA in skeletal muscle. PMID: 17555093
    40. Insulin resistance was associated with enhanced Ser phosphorylation of IRS-1, which impaired its interaction with its downstream target PKB/Akt. PMID: 19563078
    41. The decreased of IR, IRS-1, IRS-2 mRNA expression of liver may be involved in the molecular mechanism of the effects of ethanol on insulin insensitivity. PMID: 16921752
    42. Chromium supplementation can increase the expression level of IRS-1 mRNA of skeletal muscles in diabetic rats. PMID: 15862035
    43. Bushen Huoxue Huayu Recipe can increase the expression of IRS-1 and phosphorylation of tyrosine in adipose tissue. PMID: 18559242
    44. Insulin-like growth factor-I-stimulated insulin receptor substrate-1 negatively regulates Src homology 2 domain-containing protein-tyrosine phosphatase substrate-1 function in vascular smooth muscle cells. PMID: 20207740
    45. The reduced expressions of IRS-1 and IRS-2 caused lower expression of hepatic IGF-1 in the adult male rats with intrauterine growth retardation. PMID: 19088829
    46. Loss of inhibitory insulin receptor substrate-1 phosphorylation is an early event in mammalian target of rapamycin-dependent endometrial hyperplasia and carcinoma. PMID: 20179297
    47. In summary, we show that, in a rodent model of T2DM, voluntary exercise decreases circulating markers of inflammation and oxidative stress and lowers hepatic JNK activation and Ser(307)-phosphorylated insulin receptor substrate-1. PMID: 19996384
    48. There was no significant difference of IRS-1 expression among three rat age groups. PMID: 19626997
    49. The sites of O-linked N-acetylglucosamine modification of rat and human IRS-1, were identified. PMID: 19671924
    50. Expression of IRS1 can be directly activated by beta-catenin. PMID: 19843521

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  • 数据库链接：

    KEGG: rno:25467

    STRING: 10116.ENSRNOP00000019579

    UniGene: Rn.10476

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