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  4. Recombinant Rat Metabotropic glutamate receptor 2 (Grm2), partial

Recombinant Rat Metabotropic glutamate receptor 2 (Grm2), partial

  • 中文名称：
    大鼠Grm2重组蛋白
  • 货号：
    CSB-YP009932RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Grm2重组蛋白
  • 货号：
    CSB-EP009932RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Grm2重组蛋白
  • 货号：
    CSB-EP009932RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Grm2重组蛋白
  • 货号：
    CSB-BP009932RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Grm2重组蛋白
  • 货号：
    CSB-MP009932RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Grm2
  • Uniprot No.：
    P31421
  • 别名：
    Grm2; Gprc1b; Mglur2Metabotropic glutamate receptor 2; mGluR2
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
  • 基因功能参考文献：
    1. Whereas both glutamate metabotropic receptor 2 and glutamate metabotropic receptor 4 couple to G proteins, G protein activation is mediated by mGlu4 heptahelical domain (HD) exclusively in glutamate metabotropic receptor 2-4 heterodimers. PMID: 28829739
    2. Although assumed to form exclusive homodimers, 16 possible heterodimeric mGluRs have been proposed but their existence in native cells remains elusive. Study identified mGlu2-4 specific pharmacological fingerprints that were also observed in a neuronal cell line and in lateral perforant path terminals naturally expressing mGlu2 and mGlu4. Results show the existence of mGlu2-4 heterodimers in native cells. PMID: 28661401
    3. Findings suggest a time dependent evolving pattern of mGluR2/3 density during the pathogenesis of mesial temporal lobe epilepsy and provide insights for utilizing this data for in vivo imaging to predict the specific time points and responsiveness to the therapy targeting mGluR2/3. PMID: 27565411
    4. Grm2 mutant animals display characteristics of altered emotionality, impulsivity and risk-related behaviors and increased voluntary alcohol intake. PMID: 26987983
    5. These data reveal histone modification modulates mGluR2/3 expression in the spinal cord to attenuate stressinduced visceral hypersensitivity. PMID: 27385724
    6. Study aimed at further characterizing the effects of prenatal immune activation on 5-HT2A and mGlu2/3 receptor function in male and female rat offspring PMID: 26051401
    7. This study demonstrated that the Male prenatal chronic mild stress rats expressed significantly higher mGluR2/3 in the prefrontal cortex but lower in female amygalda. PMID: 26071959
    8. Report mGlu(2) receptor-mediated inhibition of conditioned avoidance behavior in rats. PMID: 24486391
    9. Activation of mGluR2 receptors in prefrontal cortex reversed sensory motor gating deficits. PMID: 24067361
    10. these data point to mGluR2 as an origin of alcohol preference and a potential therapeutic target. PMID: 24082084
    11. Selective group II metabotropic glutamate type 2 receptor allosteric potentiators show an anti-panic efficacy similar to alprazolam. PMID: 22914798
    12. activation of either the mGlu3 or mGlu2 receptor subtype alone can be sufficient to induce an LTD of synaptic transmission in the cortical input to the lateral amygdala. PMID: 22531751
    13. In brain slices, using optic switches, it was determined that mGluR2 modulated the threshold for escape behavior. PMID: 23455609
    14. Alcohol-dependent rats show escalation of ethanol seeking, which was abolished by restoring mGluR(2) expression in the infralimbic cortex via viral-mediated gene transfer PMID: 23407939
    15. Data show that glutamatergic transmission at CA1-subiculum (SUB) synapses is depressed by group II mGluRs in a cell-type specific manner. PMID: 22984605
    16. The cAMP-PKA pathway may play an important role in the group II mGluRs-mediated regulation of respiratory rhythmical discharge activity in the brainstem slice of neonatal rats. PMID: 21681341
    17. In SCG neurons, mGluR2/4 dimers were not inhibited by the mGluR2-selective NAM (Z)-1-[2-cycloheptyloxy-2-(2,6-dichlorophenyl)ethenyl]-1H-1,2,4-triazole (Ro 64-5229), supporting the two-site model. PMID: 22653971
    18. These results suggest that the mGluR1-evoked activation of TRPC channels is required for the induction of cerebellar LTD. PMID: 22973014
    19. analysis of extinction-dependent alterations in corticostriatal mGluR2/3 and mGluR7 receptors following chronic methamphetamine self-administration in rats PMID: 22479593
    20. Presynaptic stimulation at 5 Hz for 10 min induces depression of glutamatergic transmission via activation of presynaptic mGluR II suggesting an endogenous role for mGluR II in modulating glutamatergic transmission. PMID: 21677028
    21. We identified eight residues in the allosteric binding pocket that are crucial for non-competitive antagonism of agonist-dependent activation of mGlu2. PMID: 21470207
    22. These data demonstrate that intersubunit movement at the level of the cysteine-rich domain represents a key step in metabotropic glutamate receptor activation. PMID: 21896740
    23. Data show that microinjection of the mglu2/3 antagonist LY341495 at sites throughout the medial shell of the nucleus accumbens suppressed appetitive motivation to eat and drink. PMID: 21198990
    24. Data from an in vitro hemisected neonatal spinal cord preparation suggest that mGlu2 receptor (in contrast to most G protein-coupled receptors) is resistant to agonist-induced homologous desensitization [using (2R,4R)-APDC]. PMID: 20826132
    25. Activation of group II mGluRs reduces neuropathic pain probably by attenuating glutamatergic and glycinergic input to spinal dorsal horn neurons. PMID: 20923868
    26. Activation of Group II mGlu receptors enhances phencyclidine-induced dopamine release. (group 2 mGluRs) PMID: 12505620
    27. low voltage current in retinal ganglion cells can be enhanced by activation of mGluR2, by a mechanism that is G-protein dependent and may involve a protein tyrosine kinase step. PMID: 12837619
    28. Activation of mGluR2/3 receptors may potentiate NMDAR channel functions in prefrontal cortex through PKC-dependent mechanism. May be relevant for developing novel mGluR-related pharmacological agents for treatment of mental illnesses. PMID: 14645456
    29. Glutamate induces apoptosis of lactotropes and somatotropes through group II mGluR activation, probably by decreasing cAMP synthesis. PMID: 15208212
    30. Study reveals cellular sites of synthesis and protein distribution of group II mGlu receptors in discrete regions of rat brain. PMID: 15861463
    31. region- and subtype-specific, including splice variant specific changes in the expression of mGlu receptors in the brain with increasing age PMID: 15862522
    32. The activation of cystine/glutamate exchange by N-acetylcysteine prevents drug seeking by increasing glutamatergic tone on presynaptic group II metabotropic glutamate receptors (mGluR2/3) and thereby inhibits excitatory transmission. PMID: 16000629
    33. These data suggest that mGluRs of groups II and III can inhibit nociceptive processing in amygdala (CeLC) neurons. PMID: 16760343
    34. we explore whether mGluR2 expression is affected in a rat model of temporal lobe epilepsy PMID: 16793029
    35. Pharmacological activation of group II mGluRs such as mGluR3 modifies both stress- and cue-induced ethanol-seeking. PMID: 17005860
    36. These results indicate that mGluR2 and mGluR3 are coupled to Galphai subunits and play roles in glutamate-mediated signaling in taste transductions. PMID: 17216195
    37. results describe the effect of 3-mercaptopropionic acid induced repetitive seizures on mGLUR2/3 and mGLUR4a in the cerebellum PMID: 17401670
    38. Our results demonstrate a complex role for mGluR2/3 receptors in modulating anxiety circuitry, including direct inhibition and reduction of excitatory drive. PMID: 17948876
    39. These data indicate a long-lasting impairment of mGlu2/3 expression that may contribute to abnormal presynaptic plasticity, exaggerate glutamate release and hyperexcitability in temporal lobe epilepsy. PMID: 18804094
    40. data indicate group II metabotropic glutamate receptors & TRPV1 receptors are co-expressed on peripheral nociceptors & activation of mGluRs can inhibit painful sensory transmission following TRPV1 activation PMID: 19026992
    41. data suggest that spinal mGluR2/3 contributes to the generation of mechanical allodynia induced by peripheral inflammation PMID: 19429193
    42. data suggest a novel mechanism for postsynaptic group II mGluRs to fine-tune baroreceptor signal transmission in the nucleus tractus solitarius PMID: 19776267

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse. Cell projection, dendrite.
  • 蛋白家族：
    G-protein coupled receptor 3 family
  • 组织特异性：
    Is widely distributed in the CNS and prominent expression is seen in Golgi cells of the cerebellum and some particular neuronal cells in other brain regions.
  • 数据库链接：

    KEGG: rno:24415

    STRING: 10116.ENSRNOP00000017607

    UniGene: Rn.9681

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