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  4. Recombinant Rat Metabotropic glutamate receptor 3 (Grm3), partial

Recombinant Rat Metabotropic glutamate receptor 3 (Grm3), partial

  • 中文名称：
    大鼠Grm3重组蛋白
  • 货号：
    CSB-YP009933RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Grm3重组蛋白
  • 货号：
    CSB-EP009933RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Grm3重组蛋白
  • 货号：
    CSB-EP009933RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Grm3重组蛋白
  • 货号：
    CSB-BP009933RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Grm3重组蛋白
  • 货号：
    CSB-MP009933RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Grm3
  • Uniprot No.：
    P31422
  • 别名：
    Grm3; Gprc1c; Mglur3Metabotropic glutamate receptor 3; mGluR3
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
  • 基因功能参考文献：
    1. Results indicate a double function for glial mGlu3R activation against Abeta neurotoxicity: (i) it increases the release of protective neurotrophins such as sAPPalpha and BDNF, and (ii) it induces amyloid removal from extracellular space by glia-mediated phagocytosis. PMID: 28495373
    2. Following activation of mGluR3 receptors in prefrontal cortex, sensory motor gating deficits were reversed. PMID: 24067361
    3. An inflammatory environment triggers an opposite gene expression regulation of two predominant subtypes, mGluR3 and mGlur5, found in glial cells. PMID: 22245498
    4. New evidence for the antiparkinsonian efficiency of group III mGlu receptor agonism points to the regulation of the overactive subthalamo-nigral connection as a main site of action in an early stage of Parkinson's disease. PMID: 22245662
    5. Data suggest that ezrin is required for the structural plasticity of PAPs and mGluRs can stimulate PAP plasticity. PMID: 21753079
    6. group 3 mglurs increase gaba release from the posterior pituitary PMID: 12098644
    7. Modulation of short-term plasticity by activation of group III metabotropic glutamate receptors (mGluR) was investigated in the lateral perforant path of the dentate gyrus PMID: 12363402
    8. mGluR3 can modulate high potassium, low calcium-induced spontaneous epileptiform burst activity in acute rat hippocampal slice dentate granule cells. PMID: 12694929
    9. Binding of [3H]DCG-IV to rat mGlu3 in human kidney cells is very sensitive to mutagenesis-induced perturbations. These findings define essential features of the ligand-binding pocket of mGlu3 and provide opportunities for structure-based drug design PMID: 12887692
    10. distinct functions for mGluR2 and mGluR3 and dynamic regulation of mGluR3 by PP2C PMID: 14663150
    11. role of glutamate carboxypeptidase II inhibition in preventing programmed cell death in neurons exposed to high glucose; this neuroprotection is mediated through the mGluR3 receptor, most likely by increasing the extracellular NAAG concentration PMID: 15030392
    12. data suggest an essential role for mGluR3 in long-term depression , and a modulatory role for mGluR3 in long-term potentiation PMID: 15635057
    13. Activation of a group III mGluR in bone marrow stromal cells inhibits a Ca(2+)-permeable plasma membrane channel, reducing [Ca(2+)](i) and suppressing generation of NO. PMID: 15799084
    14. mGluR autoreceptors function to change the synaptic state and distribute metabolic demand, rather than to depress synaptic amplitude PMID: 15845577
    15. mGluR3 is coupled to cGMP levels and that mGluR3-induced reduction of cGMP levels is mediated by different G proteins in cerebellar astrocytes and neurons. PMID: 16417588
    16. we explore whether mGluR3 expression is affected in a rat model of temporal lobe epilepsy PMID: 16793029
    17. Pharmacological activation of group II mGluRs such as mGluR2 modifies both stress- and cue-induced ethanol-seeking. PMID: 17005860
    18. Our results demonstrate that stimulation of group III mGluRs in the striatum, GP or SNr exerts antiparkinsonian-like effects in rats. PMID: 17224239
    19. These results support the conclusions that activating glial mGluR3 protects neurons from glucose-induced oxidative injury by increasing free radical scavenging and stabilizing mitochondrial function, through increased GSH antioxidant defense. PMID: 17402968
    20. We suggest that the concurrent depression of action potential-evoked, and enhancement of action potential-independent glutamate release operate through discrete second messenger/effector systems at excitatory entorhinal terminals in rat brain. PMID: 17630217
    21. Posttraumatic secondary brain insults exacerbate neuronal injury by altering expression of metabotropic glutamate receptors. PMID: 18021417
    22. These data confirm that activation of group III mGlu receptors inhibits GABA release in the globus pallidus, thereby supporting their hetero-receptor role in vivo. PMID: 18035348
    23. These data indicate a long-lasting impairment of mGlu2/3 expression that may contribute to abnormal presynaptic plasticity, exaggerate glutamate release and hyperexcitability in temporal lobe epilepsy PMID: 18804094
    24. The expression, purification, crystallization and preliminary X-ray crystallographic analysis of mGluR3 extracellular domain, is reported. PMID: 19255473
    25. The present study aimed to examine the role of mGluR3/mGluR7 in lead-induced neurotoxicity. PMID: 19374778

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 3 family
  • 组织特异性：
    Is widely distributed in the CNS. Predominant expression is seen in the neuronal cells of the cerebral cortex, dentate gyrus, and glial cells throughout brain regions.
  • 数据库链接：

    KEGG: rno:24416

    STRING: 10116.ENSRNOP00000007572

    UniGene: Rn.41715

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