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  4. Recombinant Rat Phosphatidylinositol 3-kinase catalytic subunit type 3 (Pik3c3), partial

Recombinant Rat Phosphatidylinositol 3-kinase catalytic subunit type 3 (Pik3c3), partial

  • 中文名称：
    大鼠Pik3c3重组蛋白
  • 货号：
    CSB-YP017997RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Pik3c3重组蛋白
  • 货号：
    CSB-EP017997RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Pik3c3重组蛋白
  • 货号：
    CSB-EP017997RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Pik3c3重组蛋白
  • 货号：
    CSB-BP017997RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Pik3c3重组蛋白
  • 货号：
    CSB-MP017997RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Pik3c3
  • Uniprot No.：
    O88763
  • 别名：
    Pik3c3; Vps34; Phosphatidylinositol 3-kinase catalytic subunit type 3; PI3-kinase type 3; PI3K type 3; PtdIns-3-kinase type 3; EC 2.7.1.137; Phosphoinositide-3-kinase class 3
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the cont...显示更多
  • 基因功能参考文献：
    1. Data show that the cardioprotective effect of paeonol and danshensu combination is, at least partly, via activation of Nrf2/HO-1 signaling and involvement of the PI3K/Akt cell survival signaling pathway. PMID: 27021411
    2. reveal a novel function of GABP in the regulation of autophagy via transcriptional activation of the BECN1-PIK3C3 complex PMID: 25046113
    3. Phosphoinositol 3 kinase inhibitor, LY294002 increases bcl-2 protein and inhibits okadaic acid-induced apoptosis in Bcl-2 expressing renal epithelial cells. PMID: 11773707
    4. secretion in pancreatic acinar cells: involvement of phosphatidylinositol 3-kinase PMID: 11839273
    5. oxidative stress induces activation of PI3K, which leads to p70S6K1 activation and enlargement of cell size PMID: 11861821
    6. Phosphatidylinositol 3-kinase but not tuberin is required for PDGF-induced cell migration. PMID: 11880313
    7. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated activity in muscle PMID: 12006582
    8. Ang II stimulates the PI3K-sensitive release of AA which stimulates MAPK to phosphorylate cPLA(2) and enhance AA release. This mechanism may play an important role in the Ang II-induced growth of vascular smooth muscle cells. PMID: 12051686
    9. internalized AT1 receptors are processed via vesicles that resemble multivesicular bodies, and recycle to the cell surface by a rapid PI 3-kinase-dependent recycling route, as well as by a slower pathway that is less sensitive to PI 3-kinase inhibitors PMID: 12070129
    10. activation of the PI3-K/Akt signaling pathway regulates the development of the differentiated trophoblast giant cell phenotype. PMID: 12089343
    11. Data show that IKK beta and phosphatidylinositol 3-kinase/Akt play a critical role in bacteria-induced RelA phosphorylation and NF-kappa B activation. PMID: 12140289
    12. AT2 receptor-mediated activation of SHP-1 and the consequent inhibition IRS-2-associated PI3K activity contributed at least partly to the inhibition of Akt phosphorylation, thereby inducing apoptosis PMID: 12198247
    13. hexosamine biosynthesis pathway-mediated activation of PI 3-kinase has an insulin-like effect to translocate GLUT4 and causes PI 3-kinase-mediated translocation of PKC-zeta/lambda and PKC-varepsilon but not other PKC isoforms tested (alpha, beta, delta). PMID: 12242025
    14. Results show that leukotriene B(4) binds BLT1 and activates G(i)-like protein, and both phosphatidylinositol 3-kinase (PI3-K) activation and a sustained calcium elevation by calcium influx are necessary for enzyme release in these cells. PMID: 12244116
    15. observations demonstrate that the phosphatidylinositol 3-kinase signaling pathway is involved in embryonic testis cord formation and mesonephros cell migration PMID: 12444071
    16. Insulin activates this enzyme in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia. PMID: 12540590
    17. alterations in PI3K activity in response to parathyroid hormone with aging PMID: 12581861
    18. activation of TrkB/PI3-K and protein synthesis signaling pathway by BDNF in the hippocampus is important for spatial memory. PMID: 12610654
    19. results implicate phosphatidylinositol 3-kinase/Akt kinase pathways in angiotensin II/insulin-like growth factor-1 regulation of inducible nitric oxide synthase in vascular smooth muscle cells PMID: 12624428
    20. Activation of this enzyme by D2 receptor prevents apoptosis in dopaminergic cell lines PMID: 12683952
    21. VLDLs induce smooth muscle cell proliferation by activating the PI3K pathway and nuclear NFAT translocation PMID: 12730091
    22. suggests that PI 3-kinase contributes to the maintenance of synaptic transmission during periods of high activity PMID: 12754199
    23. NF-kappa B is probably principal contributor to downstream activation of PI3-kinase-Akt pathway. PI3-kinase-Akt pathway acts as survival signal and plays key role in regulation of apoptotic change in mesangial cells principally via NF-kappa B. PMID: 12761242
    24. PI3K/Akt signaling pathway is activated intrinsically and has a neuroprotective effect on injured retinal ganglion cells. PMID: 12789537
    25. study shows for the first time that the phosphatidylinositol 3-kinase/Akt protein pathway plays a central protective role in ischemia-reperfusion injury of the rat liver and that lipoic acid administration attenuates injury via this pathway PMID: 12816756
    26. ovine betaretrovirus Env proteins transform rodent fibroblasts by indirectly activating the PI3K/Akt pathway PMID: 12829832
    27. results support a mechanism for EGF receptor-mediated mitogenic signalling in hepatocytes where ERK has an obligatory role, acting in concert with PI3-kinase, and augmented by p38 PMID: 12876381
    28. Effect of Ly-Y-294002 on exication-contraction coupling occurs through inhibition of PI3K-mediated L-type Ca(2+) channel activity. PMID: 14563664
    29. a central role of phosphoinositide 3-kinases in dendrite formation PMID: 14578357
    30. activation of PI3K and p38 MAPK but not of MEK1/ERK by the calcium sensing receptor promotes proliferation of H-500 cells as well as affords protection against apoptosis. PMID: 14645111
    31. Estrogen, via a receptor-dependent, PI3K/Akt-mediated pathway, transcriptionally upregulates CYP activity, leading to an enhanced arteriolar response to shear stress. PMID: 14670845
    32. Results suggest that the p42/44 MAP kinase and phosphatidylinositol 3-OH kinase pathways are important in regulating alveolar type II cell proliferation in response to keratinocyte growth factor. PMID: 14742297
    33. The p110delta isoform of PI3-kinase is implicated in arterial hyperresponsiveness in hypertension at the level of both large and small arteries. PMID: 14993194
    34. PI 3-kinase has a role in mediating the acute lipid-lowering effects of leptin in liver and is involved in leptin resistance PMID: 14993225
    35. Expression of MUC1 in 3Y1 cells activates the anti-apoptotic PI3K/Akt and Bcl-x(L) pathways. PMID: 14999001
    36. The PI3-kinase pathway plays a role in PDGF-induced PSC migration and is partially involved in mediating ERK1/2 activation. PMID: 15006556
    37. PI3K induces heat hyperalgesia, possibly by regulating TRPV1 activity, in an ERK-dependent manner. The PI3K pathway also appears to play a role that is distinct from ERK by regulating the early onset of inflammatory pain. PMID: 15385613
    38. The increased ratio of PI 3-kinase catalytic to regulatory subunits favors enhanced insulin signaling, which likely contributes to greater Akt phosphorylation and improved insulin sensitivity associated with CR in skeletal muscle. PMID: 15613677
    39. Simultaneous inhibition of PI3K and PKC can induce GSK-3 overactivation, and further strengthen and prolong the Alzheimer-like tau hyperphosphorylation in N2a cells PMID: 15880264
    40. These results indicate that the NGF-induced PI 3-K signaling pathway prevents Th-triggered ER stress-specific apoptosis via inhibition of caspase-mediated apoptotic signal. PMID: 16095815
    41. tested the importance of phosphoinositide 3-kinase (PI3-K), protein kinase C (PKC), or reactive oxygen species (ROS) in E(2)-induced protection PMID: 16648180
    42. The activation of the PI3-K/Akt pathway is required for thermal preconditioning to protect CGN against apoptosis induced by low potassium. PMID: 17241518
    43. Increased expression of PI-3PK in asthmatic rat T lymphocytes is reported. PMID: 17393104
    44. In conclusion, OGD-induced phosphoinositide-3-kinase-dependent phosphorylation of GRK2 on Ser670 is a novel mechanism leading to down-regulation of GRK2 protein via a proteasome-dependent pathway. PMID: 17437535
    45. Defective phosphatidylinositol 3-kinase signaling in central control of cardiovascular effects in the nucleus tractus solitarii of spontaneously hypertensive rats. PMID: 18716370
    46. Inhibition of PI 3-K/Akt signaling pathway induces apoptosis in rat hepatic stellate cells (HSC). PMID: 18777595
    47. following high-resistance contractions, Vps34 activity is stimulated by an influx of essential amino acids such as leucine and this may prolong mTORC1 signalling and contribute to muscle hypertrophy PMID: 19015198

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  • 亚细胞定位：
    Midbody. Late endosome. Cytoplasmic vesicle, autophagosome.
  • 蛋白家族：
    PI3/PI4-kinase family
  • 数据库链接：

    KEGG: rno:65052

    STRING: 10116.ENSRNOP00000060791

    UniGene: Rn.30010

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