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  4. Recombinant Rat Sodium/potassium-transporting ATPase subunit alpha-4 (Atp1a4), partial

Recombinant Rat Sodium/potassium-transporting ATPase subunit alpha-4 (Atp1a4), partial

  • 中文名称：
    Recombinant Rat Sodium/potassium-transporting ATPase subunit alpha-4(Atp1a4) ,partial
  • 货号：
    CSB-YP734111RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Sodium/potassium-transporting ATPase subunit alpha-4(Atp1a4) ,partial
  • 货号：
    CSB-EP734111RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Sodium/potassium-transporting ATPase subunit alpha-4(Atp1a4) ,partial
  • 货号：
    CSB-EP734111RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Sodium/potassium-transporting ATPase subunit alpha-4(Atp1a4) ,partial
  • 货号：
    CSB-BP734111RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Sodium/potassium-transporting ATPase subunit alpha-4(Atp1a4) ,partial
  • 货号：
    CSB-MP734111RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Atp1a4
  • Uniprot No.：
    Q64541
  • 别名：
    Atp1a4; Atp1al2Sodium/potassium-transporting ATPase subunit alpha-4; Na(+)/K(+) ATPase alpha-4 subunit; EC 7.2.2.13; Sodium pump subunit alpha-4
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility.
  • 基因功能参考文献：
    1. Ouabain interactions with the alpha4 isoform of the sodium pump trigger non-classical steroid hormone signaling and integrin expression in spermatocytes. PMID: 27599714
    2. Atp1a4 is tuned for changing extracellular environments during sperm capacitation. PMID: 26476261
    3. Na,K-ATPase alpha4 activity is up-regulated during sperm capacitation through mechanisms that involve both increases in molecular activity and levels of alpha4 at the sperm plasma membrane. PMID: 22441762
    4. These results provide new genetic evidence for the role of the ATP1A4 isoform in sperm motility, under both noncapacitating and capacitating conditions. PMID: 20826726
    5. In sperm, alpha4 is isoform primarily involved in controlling transmembrane Na+ gradient; alpha4 activity is necessary for maintaining membrane potential, [Ca2+]i, and [H+]i. Thus, alpha4 activity is necessary to maintain sperm motility. PMID: 20179187
    6. This isoform is developmentally expressed in haploid and diploid spermatozoa. PMID: 12763881

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Cation transport ATPase (P-type) (TC 3.A.3) family, Type IIC subfamily
  • 数据库链接：

    KEGG: rno:29132

    STRING: 10116.ENSRNOP00000062079

    UniGene: Rn.224462

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