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  4. Recombinant Rat Sprouty-related, EVH1 domain-containing protein 2 (Spred2)

Recombinant Rat Sprouty-related, EVH1 domain-containing protein 2 (Spred2)

  • 中文名称：
    大鼠Spred2重组蛋白
  • 货号：
    CSB-YP660336RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Spred2重组蛋白
  • 货号：
    CSB-EP660336RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Spred2重组蛋白
  • 货号：
    CSB-EP660336RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Spred2重组蛋白
  • 货号：
    CSB-BP660336RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Spred2重组蛋白
  • 货号：
    CSB-MP660336RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Spred2
  • Uniprot No.：
    Q3C2P8
  • 别名：
    Spred2; Sprouty-related; EVH1 domain-containing protein 2; Spred-2
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-410
  • 氨基酸序列
    MTEETHPDDD SYIVRVKAVV MTRDDSSGGW FPQEGGGISR VGVCKVMHPE GNGRSGFLIH GERQKDKLVV LECYVRKDLV YTKANPTFHH WKVDNRKFGL TFQSPADARA FDRGVRKAIE DLIEGSTTSS STIHNEAELG DDDVFTTATD SSSNSSQKRE PNTRTISSPT SCEHRRIYTL DPYPMDLYHP DQRLPRSYPQ VTFPEDDEEI VRINPREKIW MTGYEDYRHA PVRGKYLDST EDADSYVRFA KGEVPKHEYT YPYVDSSDFG FGEDPKGNVI KTQPPRAKSR RRKENGERSR CVYCRDMFNH EENRRGHCQD APDAVRTCIR RVSCMWCADS MLYHCMSDPE GDYTDPCSCD TSDEKFCLRW MALIALSFLA PCMCCYLPLR ACHHCGVMCR CCGGKHKAAA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Negatively regulates Ras signaling pathways and downstream activation of MAP kinases. Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2. Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells.
  • 基因功能参考文献：
    1. Tyrosines 303/343/353 within the Sprouty-related domain of Spred2 are essential for its interaction with the p85 subunit of phosphatidylinositol 3-kinase. PMID: 22305891
  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
  • 组织特异性：
    Expressed in the eye, with higher expression in lens epithelium than in lens fiber cells at postnatal day 15.
  • 数据库链接：

    KEGG: rno:305539

    STRING: 10116.ENSRNOP00000006573

    UniGene: Rn.225245

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