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  4. Recombinant Rat Voltage-dependent L-type calcium channel subunit alpha-1D (Cacna1d), partial

Recombinant Rat Voltage-dependent L-type calcium channel subunit alpha-1D (Cacna1d), partial

  • 中文名称：
    Recombinant Rat Voltage-dependent L-type calcium channel subunit alpha-1D(Cacna1d) ,partial
  • 货号：
    CSB-YP004400RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Voltage-dependent L-type calcium channel subunit alpha-1D(Cacna1d) ,partial
  • 货号：
    CSB-EP004400RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Voltage-dependent L-type calcium channel subunit alpha-1D(Cacna1d) ,partial
  • 货号：
    CSB-EP004400RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Voltage-dependent L-type calcium channel subunit alpha-1D(Cacna1d) ,partial
  • 货号：
    CSB-BP004400RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Voltage-dependent L-type calcium channel subunit alpha-1D(Cacna1d) ,partial
  • 货号：
    CSB-MP004400RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cacna1d
  • Uniprot No.：
    P27732
  • 别名：
    Cacna1d; Cach3; Cacn4; Cacnl1a2; Cchl1a2Voltage-dependent L-type calcium channel subunit alpha-1D; Calcium channel; L type; alpha-1 polypeptide; isoform 2; Rat brain class D; RBD; Voltage-gated calcium channel subunit alpha Cav1.3
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. ...显示更多
  • 基因功能参考文献：
    1. Study have showned a significant effect of the autism-associated mutation A760G on the gating of CaV1.3 such that channel activation is significantly left-shifted, Ca(2+)-dependent inactivation is decreased, and deactivation is slowed, resulting in excess Ca2+ entry. However, these effects are mitigated by an increase in voltage-dependent inactivation. Also, A760G mutation differentially affects CaV1.3 splice variants. PMID: 27255217
    2. L-type channels in insulin-secreting cells are directly targeted by cGMP signaling through PKG. PMID: 28807144
    3. In addition, single-molecule localization microscopy revealed striking clusters of CaV1.3 channels surrounding clusters of BK channels and forming a multi-channel complex both in a heterologous system and in rat hippocampal and sympathetic neurons. PMID: 28665272
    4. Data indicate that in rats, central L-type calcium Cav1.2 channels, rather than Cav1.3, mediate alcohol-seeking behavior. PMID: 27905406
    5. activated Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) strongly interacts with a novel binding motif in the N-terminal domain of CaV1 LTCC alpha1 subunits that is not conserved in CaV2 or CaV3 voltage-gated Ca(2+) channel subunits. Mutations in the CaV1.3 alpha1 subunit N-terminal domain or in the CaMKII catalytic domain that largely prevent the in vitro interaction also disrupt CaMKII association with intact... PMID: 28916724
    6. When adapting Cav1.3 conductance to the changes observed after SNL. PMID: 27231046
    7. releases of Ca(2+) from the endoplasmic reticulum (ER), and consequently drives STIM1 aggregation and an inhibitory interaction with LTCCs that increases spine ER content but decreases NFATc3 nuclear translocation. PMID: 28402855
    8. The expression of Cav1.2 and Cav1.3 genes is augmented under low oxygen conditions. PMID: 25648081
    9. In conclusion, Ca(2) influx through Ca(V)1.2 or to Ca(V)1.3 channel subtypes contributes to maintenance of the resting membrane potentials of NGF-differentiated PC12 cells. PMID: 25675390
    10. Western blot analysis of the total expression levels revealed significant reductions in both Cav 1.2 and Cav 1.3 subunits from all three major hippocampal regions of aged rats. PMID: 24033980
    11. Submucosal neurons, identified by a neuronal marker (microtubule-associated protein 2), are immunoreactive for Ca(v)1.2, Ca(v)1.3 and Ca(v)2.2, expression being confirmed by reverse transcription plus the polymerase chain reaction PMID: 23807706
    12. Identification of residues that are responsible for the abnormal gating behavior of rCav1.3 from superior cervical ganglia neurons. PMID: 22760075
    13. analysis of functional characterization of alternative splicing in the C terminus of L-type CaV1.3 channels PMID: 21998309
    14. Reduced expressions of Cav1.3 and RyR1 in the corpus cavernosum of the penis may be one of the mechanisms underlying age-related erectile dysfunction in aged rats. PMID: 20218309
    15. data show that [alpha]1D Ca2+ channel has unique age-dependent expression profile and subcellular localization in the heart, suggesting a developmental stage-dependent specific function PMID: 21378599
    16. The aim of this study is to investigate LVSCC-A1C, LVSCC-A1D expression levels and NGF release in VDR-silenced primary cortical neurons. PMID: 21408608
    17. These results show a physical and functional interaction between CaV1.3 and GABABR. PMID: 20627102
    18. The traditional modeling of irritable bowel syndrome in rats alters the expression of Cav1.2 and Cav1.3. PMID: 20137275
    19. Our results demonstrate a novel mechanism for Ca(2+)-dependent neural facilitation via Cav1.2 channels that may intensify postsynaptic Ca(2+) signals during high-frequency stimulation. PMID: 20392935
    20. This paper furnishes new evidence that allosteric inhibition of the activation gate is the ultimate outcome for the calmodulin-mediated Ca2+/calmodulin-inactivation of CaV1.3 channels. PMID: 20142517
    21. Androgen can regulate erectile function via RyR1 and CaV1.3. PMID: 20112737
    22. The location of L-type Ca(v)1.2 and Ca(v)1.3 channels in distal dendrites and spines on hippocampal neurons places them at appropriate sites where they could initiate synapse to nucleus signalling. PMID: 19665524
    23. these results show that Cav1.3 L-type Ca2+ channels supports DA neuron excitability by virtue of their optimal gating without a significant contribution of their ion selectivity PMID: 20007466
    24. mRNA transcripts for the voltage-gated Ca2+ channel alpha 1D subunit have been detected in rat astrocytes. PMID: 12555202
    25. Age-related increases in alpha(1D) hippocampal calcium channels cause memory impairment in rats. Nimodipine improves these deficits and reduces expression of hippocampal alpha(1D) protein. PMID: 12591156
    26. Increase in cytoplasmic distribution of channels under high [Ca2+]i conditions. Cav1.3 channel trafficking is involved in glucose desensitization of pancreatic beta-cells. PMID: 14534084
    27. The proline-rich region in C termini of CaV1.3a subunit binds to Shank Src homology 3 domain. The presence of Shank-binding motifs in CaV1.3a sequence is both necessary and sufficient for synaptic clustering of CaV1.3 L-type Ca2+ channels. PMID: 15689539
    28. The modulation of alpha(1D) Ca(2+) channel by PKC was prevented by dialyzing cells with a 35-amino acid peptide mimicking the alpha(1D) NH(2)-terminal region comprising S81. PMID: 16973824
    29. The Ca(2+) necessary for contraction of myosin II in the terminal web enters via an L-type channel, most likely Ca(v)1.3, and is dependent on SGLT1. PMID: 17272349
    30. In times of dietary sufficiency Ca(v)1.3 may mediate a significant pathway of glucose-stimulated Ca(2+) entry into the body and that luminal supply of Ca(2+) is necessary for GLUT2-mediated glucose absorption. PMID: 17272350
    31. alternative splicing of alpha1 1.3 may influence activity-dependent regulation of Ca(v)1.3 channels at the synapse PMID: 17287512
    32. acute and long term effects of high-K on RyRs were selectively blocked by small interfering RNA-mediated silencing of Ca(v)1.3 PMID: 17823125
    33. complex role of alpha1D Ca channel not only in physiological settings but also in pathological settings such as atrial fibrillation PMID: 17909852
    34. The mRNA level of CaV1.2 exceeded that of CaV1.3 two-fold; knock-down of CaV1.3 did not affect glucose-stimulated insulin secretion. PMID: 18562674
    35. Phosphorylation of the consensus sites of protein kinase A on alpha1D L-type calcium channel. PMID: 19074150
    36. results indicate that in the spinal cord & brain stem Ca(V)1.3 is probably a common calcium channel used by many kinds of neurons to facilitate neuronal information processing via certain intracellular mechanisms, for instance, persistent inward currents PMID: 19136044

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Calcium channel alpha-1 subunit (TC 1.A.1.11) family, CACNA1D subfamily
  • 组织特异性：
    Expressed in brain, pancreatic islets and B-lymphocytes.
  • 数据库链接：

    KEGG: rno:29716

    STRING: 10116.ENSRNOP00000051407

    UniGene: Rn.89671

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