Recombinant Human SLP adapter and CSK-interacting membrane protein (SCIMP)
In Stock
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中文名称：
人SCIMP重组蛋白
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货号：
CSB-CF754405HU
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规格：
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图片：
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其他：
产品详情
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纯度：
Greater than 85% as determined by SDS-PAGE.
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生物活性：
Not Test
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基因名：
SCIMP
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Uniprot No.：
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别名：
SLP65/SLP76, Csk-interacting membrane protein
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种属：
Homo sapiens (Human)
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蛋白长度：
Full Length
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来源：
in vitro E.coli expression system
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分子量：
22.7 kDa
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表达区域：
1-145aa
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氨基酸序列
MDTFTVQDSTAMSWWRNNFWIILAVAIIVVSVGLGLILYCVCKWQLRRGKKWEIAKPLKHKQVDEEKMYENVLNESPVQLPPLPPRNWPSLEDSSPQEAPSQPPATYSLVNKVKNKKTVSIPSYIEPEDDYDDVEIPANTEKASF
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
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蛋白标签：
N-terminal 10xHis-tagged
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产品提供形式：
Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
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缓冲液：
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
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复溶：
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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储存条件：
Store at -20°C/-80°C upon receipt, aliquoting is necessary for
mutiple use. Avoid repeated freeze-thaw cycles.
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保质期：
The shelf life is related to many factors, storage state,
buffer ingredients, storage temperature and the stability of the protein
itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The
shelf life of lyophilized form is 12 months at -20°C/-80°C.
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货期：
3-7 business days
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注意事项：
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
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Datasheet & COA：
Please contact us to get it.
靶点详情
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功能：
Lipid tetraspanin-associated transmembrane adapter/mediator that acts as a scaffold for Src-family kinases and other signaling proteins in immune cells. It is involved in major histocompatibility complex class II (MHC-II) signaling transduction in B cells, where it is required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation. In dendritic cells, it is involved in sustaining CLEC7A/DECTIN1 signaling after CLEC7A activation by fungal beta-glucans. It also acts as an agonist-inducible signaling adapter for TLR1,...
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基因功能参考文献：
- results suggest that SCIMP is involved in signal transduction after MHC-II stimulation and therefore serves as a regulator of antigen presentation and other APC functions. PMID: 21930792
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亚细胞定位：
Cell membrane; Single-pass membrane protein. Cell membrane; Lipid-anchor. Cytoplasmic vesicle, phagosome. Cell projection, ruffle. Cell projection, filopodium.
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组织特异性：
Expressed in antigen-presenting cells, like peripheral blood leukocytes and monocyte-derived dendritic cells (MDDC) (at protein level). Highly expressed in lymph nodes and spleen. Expressed in antigen-presenting cells. Faintly expressed in the majority of
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数据库链接：
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