Recombinant Mouse Glycerophosphoinositol inositolphosphodiesterase GDPD2 (Gdpd2)
产品详情
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基因名：
Gdpd2
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Uniprot No.：
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别名：
Gdpd2; Gde3; Obdpf; Glycerophosphoinositol inositolphosphodiesterase GDPD2; Glycerophosphodiester phosphodiesterase 3; Glycerophosphodiester phosphodiesterase domain-containing protein 2; Osteoblast differentiation promoting factor
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种属：
Mus musculus (Mouse)
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蛋白长度：
full length protein
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表达区域：
1-539
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氨基酸序列
MADSPGCCSIWARCLHCLYSCHWRKYPKQKMQTSKCDCIWFGLLFLTFLLSLGWLYIGLI
LLNDLHNFNEFLFRHWGHWMDWSLIVLLVVSLLVTYASLLLLLGLLLQLCGQPLHLHSLH
KVLLLLIVLLVAAGLVGLDIQWRQEWHSLRLSLQATAPFLHIGAVAGITLLAWPVADTFY
RIHPRGPKVLLLLLFFGVTLVIYLMPLLFISSPCIMKLRDLPPKPGLVGHRGAPMLAPEN
TLMSLRKTAECGAAVFETDVMVSSDGVPFLMHDERLSRTTNVASVFPERISAHSSDFSWA
ELQRLNAGTWFLERQPFWGAKKLSGSDRKEAENQTIPALEELLKEAAALNLSIMFDLRRP
PRNHTYYDTFVNQTLEAVLSANVSQAMVLWLPDEDRANVQQRAPRMRQIYGHQGGNWTER
PQFLNLPYQDLPALDIKALHQDNISVNLFVVNKPWLFSLLWCAGVDSVTTNACQLLQQMQ
NPLWLLPPQKYLMIWVITDCASILLLLSIFLLRGGCAKRNRTGLETAVLLTKINNFASE
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
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蛋白标签：
N-terminal 10xHis-tagged
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产品提供形式：
Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
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缓冲液：
Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
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储存条件：
Store at -20°C/-80°C upon receipt, aliquoting is necessary for
mutiple use. Avoid repeated freeze-thaw cycles.
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保质期：
The shelf life is related to many factors, storage state,
buffer ingredients, storage temperature and the stability of the protein
itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The
shelf life of lyophilized form is 12 months at -20°C/-80°C.
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货期：
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our
proteins are default shipped with normal blue ice packs, if you
request to ship with dry ice, please communicate with us in advance
and extra fees will be charged.
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注意事项：
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet & COA：
Please contact us to get it.
靶点详情
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功能：
Has glycerophosphoinositol inositolphosphodiesterase activity and specifically hydrolyzes glycerophosphoinositol, with no activity for other substrates such as glycerophosphoinositol 4-phosphate, glycerophosphocholine, glycerophosphoethanolamine, and glycerophosphoserine. Accelerates the program of osteoblast differentiation and growth. May play a role in remodeling of the actin cytoskeleton.
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基因功能参考文献：
- The results establish GDE3 as a negative regulator of the uPAR signaling network and, furthermore, highlight GPI-anchor hydrolysis as a cell-intrinsic mechanism to alter cell behavior. PMID: 28849762
- GDE3 is a novel seven-transmembrane protein with a GP-PDE-like extracellular motif expressed during osteoblast differentiation that accelerates the program of osteoblast differentiation and is involved in morphological change of cells PMID: 12933806
- GDE3 substrate GroPIns is a candidate mediator for osteoblast proliferation PMID: 19596859
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亚细胞定位：
Cell membrane; Multi-pass membrane protein. Cytoplasm. Cytoplasm, cytoskeleton. Note=Colocalizes with the actin cytoskeleton.
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蛋白家族：
Glycerophosphoryl diester phosphodiesterase family
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组织特异性：
Detected in spleen, femur and calvaria.
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数据库链接：
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