Your Good Partner in Biology Research

中文简体

ACVR2A｜ ACVR2B｜ ALPG｜ CA2｜ CD47｜ CD79A｜ CD79B｜ CLEC9A｜ EPO｜ IL4｜ ITPRIPL1｜ KITLG｜ LTBR｜ TSHR

  1. Home
  2. 抗体
  3. 单克隆抗体
  4. CD79A Monoclonal Antibody

CD79A Monoclonal Antibody

说明书
  • 中文名称：
    CD79A鼠单克隆抗体
  • 货号：
    CSB-MA961575
  • 规格：
    ￥1320
  • 图片：
    • IHC image of CSB-MA961575 diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-mouse IgG polymer labeled by HRP and visualized using 0.05% DAB.
  • 其他：

产品详情

  • 产品描述：
    CD79a单克隆抗体（CUSABIO货号：CSB-MA961575）是针对B细胞特异性表面标志物CD79a靶点研发的高特异性科研试剂，该靶点作为B细胞受体（BCR）复合物的关键信号转导亚基，在B细胞发育、分化及免疫应答调控中发挥核心作用。本产品经ELISA和免疫组化（IHC）双重平台验证，可精准识别人源CD79a抗原，其稳定的抗原结合特性使其成为研究B细胞相关免疫机制的重要工具。在免疫学研究领域，该抗体适用于B细胞淋巴瘤的分子标记分析、自身免疫性疾病（如系统性红斑狼疮）的病理机制探索以及免疫微环境中B细胞亚群的功能鉴定等科研场景。通过特异性识别跨膜结构域表位，该单克隆抗体可清晰定位B细胞在组织切片中的分布状态，同时满足体外蛋白互作研究的定量检测需求。作为经过严格质控的科研级抗体，其高批次稳定性可为流式细胞术预实验、免疫印迹交叉验证等多元化研究提供可靠支持，助力研究人员深入解析B细胞介导的免疫调控网络及疾病发生发展机制。
  • 产品名称：
    Mouse anti-Homo sapiens (Human) CD79A Monoclonal antibody
  • Uniprot No.：
    P11912
  • 基因名：
    CD79A
  • 别名：
    CD79A; IGA; MB1; B-cell antigen receptor complex-associated protein alpha chain; Ig-alpha; MB-1 membrane glycoprotein; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated protein; CD antigen CD79a
  • 宿主：
    Mouse
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from human CD79a
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    IgG2a, Kappa
  • 纯化方式：
    The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
  • 克隆号：
    20B11
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
    ELISA Protocol
    Immunohistochemistry (IHC) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

相关产品

CD79A antibodies

CD79A Proteins

靶点详情

  • 功能：
    Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases...显示更多
  • 基因功能参考文献：
    1. The incidence of MYD88 and CD79B mutations in patients with CD5(+) DLBCL is lower than that in patients with DLBCL-SS, suggesting that CD5(+) DLBCL is not the same disease as DLBCL-SS in terms of gene mutation status. PMID: 27915469
    2. Phosphorylation of CD79a causes a decrease in helical propensity in the C-terminal region, for CD79b, the opposite was observed and phosphorylation resulted in an increase of helical propensity in the C-terminal part. PMID: 24769851
    3. High intensity of caries is associated with increased levels of some salivary components - sIgA, histatin-5 and lactoperoxidase. PMID: 24974109
    4. CD79a plays a functional role in the tumor promoting effects of myeloid cells, and may represent a novel target for cancer therapy. PMID: 24146823
    5. STN produced significant antitumor effects in a mouse xenograft model of CD79A/B-mutated DLBCL. PMID: 21324920
    6. CD79a may be helpful marker in the differential diagnosis of classical Hodgkin's lymphoma and primary mediastinal B-cell lymphoma PMID: 20102401
    7. Unlike the B29 octamer motif, the mb-1 octamer motif does not have the essential sequence required for OBF-1/Bob1 interaction, therefore its promoter is not transactivated by OBF-1/Bob1. PMID: 11907094
    8. B cell-restricted mb-1 gene: expression, function, and lineage infidelity. Review. PMID: 12403343
    9. There is a somatic hypermutation of this gene in B-cell lymphoma and multiple myeloma. PMID: 12651942
    10. Results indicate that PAX5 is a more specific marker than CD79a for B-cell ALL diagnosis. PMID: 15492262
    11. lower levels of B-cell receptor surface expression observed in chronic lymphocytic leukemia are accounted for by an impaired glycosylation and folding of the mu and CD79a chains. PMID: 15591116
    12. FISH findings indicate that CD79a, despite its specificity for B-cell differentiation, represented the aberrant presence of a B-cell antigen in leukemias of distinct myeloid linage. PMID: 16271957
    13. Acute leukemia with t(8;21) coexpresses CytCD79a represent biphenotypic acute leukemia. PMID: 17350472
    14. Anti-CD79b antibodies downregulated surface B-cell receptor and were trafficked to the lysosomal-like major histocompatibility complex class II-positive compartment of a mouse xenograft model of non-Hodgkin lymphoma. PMID: 17374736
    15. Ig-alpha was phosphorylated in all myeloma IgG BCR isolates, the 31-kD variant being phosphorylated most frequently. It was not phosphorylated in normal control B cells. PMID: 17701175
    16. Median survival time of cytoplasmic CD79 alpha positive group was shorter than that of cytCD79a negative group in acute myeloid leukemia. PMID: 18160827

    收起更多

  • 相关疾病：
    Agammaglobulinemia 3, autosomal recessive (AGM3)
  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 组织特异性：
    B-cells.
  • 数据库链接：

    HGNC: 1698

    OMIM: 112205

    KEGG: hsa:973

    STRING: 9606.ENSP00000221972

    UniGene: Hs.631567

Most popular with customers

产品中心
特别关注


X