ADORA2A
腺苷A2A受体（ADORA2A）是嘌呤能受体家族成员，又称A2AR，广泛分布于中枢神经系统、免疫细胞及心血管组织。ADORA2A通过与内源性腺苷结合，调控细胞内cAMP水平，影响多巴胺能神经传递，在运动协调、睡眠调节和免疫抑制中发挥关键作用。研究显示其活性异常与帕金森病的运动功能障碍密切相关，阻断该受体可增强左旋多巴疗效。在肿瘤微环境中，A2AR激活会抑制T细胞抗肿瘤活性，这一发现推动了其与PD-1抑制剂联用的临床试验。
目前已有选择性A2AR拮抗剂伊曲茶碱（istradefylline）在日本获批用于帕金森病治疗，可改善剂末现象。针对癌症免疫治疗领域，多个小分子抑制剂如AZD4635已进入II期试验，与免疫检查点药物联用显示出协同效应。在神经精神疾病方面，A2AR调控异常还与成瘾行为、双相情感障碍相关，相关药物研发正探索其对认知功能的调节作用。ADORA2A同时成为咖啡因的作用靶点之一，解释了咖啡因提神效果的部分分子基础。
热销产品
ADORA2A Antibody (CSB-PA001376LA01HU)
验证数据
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA001376LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA001376LA01HU at dilution of 1:100
Immunofluorescent analysis of MCF-7 cells using CSB-PA001376LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
ADORA2A Antibodies
ADORA2A for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA007176 | ADORA2A Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA007183 | ADORA2A Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA001376LA01HU | ADORA2A Antibody | Human | ELISA, IHC, IF |
| CSB-PA001376LC01HU | ADORA2A Antibody, FITC conjugated | Human | |
| CSB-PA001376LD01HU | ADORA2A Antibody, Biotin conjugated | Human | ELISA |
ADORA2A Proteins
ADORA2A Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP001376DO1 CSB-EP001376DO1 CSB-BP001376DO1 CSB-MP001376DO1 CSB-EP001376DO1-B |
Recombinant Dog Adenosine receptor A2a (ADORA2A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF001376DO | Recombinant Dog Adenosine receptor A2a (ADORA2A) | in vitro E.coli expression system |
ADORA2A Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP001376HU CSB-EP001376HU CSB-BP001376HU CSB-MP001376HU CSB-EP001376HU-B |
Recombinant Human Adenosine receptor A2a (ADORA2A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ADORA2A Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP001376RA1 CSB-EP001376RA1 CSB-BP001376RA1 CSB-MP001376RA1 CSB-EP001376RA1-B |
Recombinant Rat Adenosine receptor A2a (Adora2a), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF001376RA | Recombinant Rat Adenosine receptor A2a (Adora2a) | in vitro E.coli expression system |
ADORA2A Proteins for Cavia porcellus (Guinea pig)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP001376GU1 CSB-EP001376GU1 CSB-BP001376GU1 CSB-MP001376GU1 CSB-EP001376GU1-B |
Recombinant Guinea pig Adenosine receptor A2a (ADORA2A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF001376GU | Recombinant Guinea pig Adenosine receptor A2a (ADORA2A) | in vitro E.coli expression system |
ADORA2A Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP720158MO1 CSB-EP720158MO1 CSB-BP720158MO1 CSB-MP720158MO1 CSB-EP720158MO1-B |
Recombinant Mouse Adenosine receptor A2a (Adora2a), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF720158MO | Recombinant Mouse Adenosine receptor A2a (Adora2a) | in vitro E.coli expression system |
ADORA2A Proteins for Equus caballus (Horse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP744229HO1 CSB-EP744229HO1 CSB-BP744229HO1 CSB-MP744229HO1 CSB-EP744229HO1-B |
Recombinant Horse Adenosine receptor A2a (ADORA2A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF744229HO | Recombinant Horse Adenosine receptor A2a (ADORA2A) | in vitro E.coli expression system |
