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ADRB2

ADRB2,即β2肾上腺素能受体,别名β2-AR。ADRB2是一种G蛋白偶联受体(GPCR),主要在气道平滑肌细胞、血管平滑肌、心肌等组织细胞中表达。ADRB2的作用机制主要是通过其受体激活,导致细胞内cAMP水平增加,进一步激活PKA,促进底物磷酸化,从而引起平滑肌松弛,解除支气管痉挛等症状。ADRB2激动剂是治疗哮喘和慢性阻塞性肺病(COPD)等呼吸系统疾病的重要药物,根据其作用持续时间,它们被分为短效(SABA)、长效(LABA)和超长效(Ultra-LABA)β-激动剂。ADRB2是气道平滑肌张力的重要调节剂,其功能异常与多种疾病的发生发展有关,包括夜间哮喘、肥胖、2型糖尿病和心血管疾病。

热销产品

Recombinant Human Beta-2 adrenergic receptor(ADRB2)(G16R,E27Q)-VLPs (CSB-MP001392HU(M))

验证数据

CSB-MP001392HU(M)

CSB-MP001392HU(M) is detected by Mouse anti-6*His monoclonal antibody.

CSB-MP001392HU(M)

The purity of VLPs was greater than 95% as determined by SEC-HPLC

ADRB2 Recombinant Monoclonal Antibody (CSB-RA286054A0HU)

验证数据

CSB-RA286054A0HU

IHC image of CSB-RA286054A0HU diluted at 1:100 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA286054A0HU

IHC image of CSB-RA286054A0HU diluted at 1:100 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

ADRB2 Antibodies

ADRB2 for Homo sapiens (Human)

ADRB2 for Rattus norvegicus (Rat)

ADRB2 Proteins

ADRB2 Proteins for Rattus norvegicus (Rat)

ADRB2 Proteins for Mus musculus (Mouse)

ADRB2 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

ADRB2 Proteins for Mesocricetus auratus (Golden hamster)

ADRB2 Proteins for Meriones unguiculatus (Mongolian jird) (Mongolian gerbil)

ADRB2 Proteins for Sus scrofa (Pig)

ADRB2 Proteins for Macaca mulatta (Rhesus macaque)

ADRB2 Proteins for Bos taurus (Bovine)

ADRB2 Proteins for Tscherskia triton (Greater long-tailed hamster)

ADRB2 Proteins for Cavia porcellus (Guinea pig)

ADRB2 Proteins for Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)

ADRB2 Proteins for Felis catus (Cat) (Felis silvestris catus)

ADRB2 Proteins for Homo sapiens (Human)