C6

C6全称为补体成分6，是补体系统终末通路的核心分子之一，负责与C5b、C7-C9共同组装成膜攻击复合物，直接破坏病原体或异常细胞的脂质膜结构。该蛋白先天性缺陷患者易反复感染脑膜炎奈瑟菌或淋球菌，部分研究还发现其水平异常与妊娠期高血压、非典型溶血尿毒综合征等疾病相关。在自身免疫领域，C6过度激活可能导致补体介导的血管内皮损伤，与抗磷脂抗体综合征等病理过程存在关联。
目前针对补体系统的药物开发多聚焦于上游成分（如C5抑制剂依库珠单抗），而直接靶向C6的疗法仍属空白。2021年有研究报道了一种特异性阻断C6功能的人源化抗体，在体外实验中可抑制补体终末通路引发的溶血反应，但尚未推进至临床。近年发现某些海洋生物毒素能选择性干扰C6与其他补体蛋白的结合，为开发新型免疫调节剂提供了线索，其转化应用仍需长期验证。

热销产品

C6 Antibody (CSB-PA004036LA01HU)

验证数据

Western Blot
Positive WB detected in: Rat liver tissue, Mouse kidney tissue
All lanes: C6 antibody at 2.7μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 105 kDa
Observed band size: 105 kDa

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA004036LA01HU at dilution of 1:100

Human Complement component C6(C6) ELISA kit (CSB-EL004036HU)

验证数据

货号：CSB-EL004036HU

规格：96T/48T

灵敏度：15.6 pg/mL

检测范围：62.5 pg/mL-4000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

C6 Antibody

C6 Protein

C6 ELISA Kit

C6 Antibodies

C6 for Homo sapiens (Human)

产品货号	产品名称	种属反应性	应用类型
CSB-PA001093	C6 Antibody	Human,Rat	WB, IHC, ELISA
CSB-PA004036LA01HU	C6 Antibody	Human, Mouse, Rat	ELISA, WB, IHC
CSB-PA004036LB01HU	C6 Antibody, HRP conjugated	Human	ELISA
CSB-PA004036LD01HU	C6 Antibody, Biotin conjugated	Human	ELISA

C6 Proteins

C6 Proteins for Homo sapiens (Human)

产品货号	产品名称	来源
CSB-YP004036HU CSB-EP004036HU CSB-BP004036HU CSB-MP004036HU CSB-EP004036HU-B	Recombinant Human Complement component C6 (C6), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C6 Proteins for Pan troglodytes (Chimpanzee)

产品货号	产品名称	来源
CSB-YP004036EQV CSB-EP004036EQV CSB-BP004036EQV CSB-MP004036EQV CSB-EP004036EQV-B	Recombinant Pan troglodytes Complement component C6 (C6), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C6 Proteins for Pongo pygmaeus (Bornean orangutan)

产品货号	产品名称	来源
CSB-YP004036EXP CSB-EP004036EXP CSB-BP004036EXP CSB-MP004036EXP CSB-EP004036EXP-B	Recombinant Pongo pygmaeus Complement component C6 (C6), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C6 Proteins for Bos taurus (Bovine)

产品货号	产品名称	来源
CSB-YP645889BO CSB-EP645889BO CSB-BP645889BO CSB-MP645889BO CSB-EP645889BO-B	Recombinant Bovine Complement component C6 (C6), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C6 Proteins for Rattus norvegicus (Rat)

产品货号	产品名称	来源
CSB-YP770520RA CSB-EP770520RA CSB-BP770520RA CSB-MP770520RA CSB-EP770520RA-B	Recombinant Rat Complement component C6 (C6), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C6 Proteins for Subterranean clover stunt virus (strain F) (SCSV)

产品货号	产品名称	来源
CSB-YP774843SHAO CSB-EP774843SHAO CSB-BP774843SHAO CSB-MP774843SHAO CSB-EP774843SHAO-B	Recombinant Subterranean clover stunt virus Para-Rep C6 (C6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli