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CCL2

CCL2,即趋化因子配体2,别名MCP-1、SCYA2、MCAF、SMC-CF。CCL2的作用机制主要是通过与其受体CCR2结合,激活细胞迁移过程,尤其是在血液单核细胞、记忆T淋巴细胞和自然杀伤细胞的迁移中起关键作用。CCL2还可以与非典型趋化因子受体ACKR1、ACKR2和蛋白聚糖的糖胺聚糖链结合。CCL2对免疫细胞的行为有着深远的影响,包括白细胞的粘附、极化、效应分子的分泌、自噬、杀伤以及存活,尤其在免疫细胞的正常招募、组织重塑、血管生成等生理过程中发挥着至关重要的作用。CCL2的异常表达与多种疾病如关节炎、动脉粥样硬化等的发生和发展密切相关。

热销产品

Recombinant Human C-C motif chemokine 2 (CCL2) (CSB-EP004783HUb1)

验证数据

CSB-EP004783HUb1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CCL2 Recombinant Monoclonal Antibody (CSB-RA004783MA1HU)

验证数据

CSB-RA004783MA1HU

IHC image of CSB-RA004783MA1HU diluted at 1:100 and staining in paraffin-embedded human melanoma cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Human IgG labeled by HRP and visualized using 0.05% DAB.

CCL2 Antibodies

CCL2 for Homo sapiens (Human)

CCL2 for Mus musculus (Mouse)

CCL2 Proteins

CCL2 Proteins for Mus musculus (Mouse)

CCL2 Proteins for Homo sapiens (Human)

CCL2 Proteins for Bos taurus (Bovine)

CCL2 Proteins for Sus scrofa (Pig)

CCL2 Proteins for Oryctolagus cuniculus (Rabbit)

CCL2 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

CCL2 Proteins for Macaca mulatta (Rhesus macaque)

CCL2 Proteins for Rattus norvegicus (Rat)

CCL2 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

CCL2 Proteins for Cavia porcellus (Guinea pig)

CCL2 Proteins for Pongo abelii (Sumatran orangutan)

CCL2 Proteins for Equus caballus (Horse)

CCL2 ELISA Kit

CCL2 ELISA Kit for Bos taurus (Bovine)

CCL2 ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)

CCL2 ELISA Kit for Guinea Sus scrofa (Pig)

CCL2 ELISA Kit for Homo sapiens (Human)

CCL2 ELISA Kit for Monkey

CCL2 ELISA Kit for Sus scrofa (Pig)

CCL2 ELISA Kit for Oryctolagus cuniculus (Rabbit)

CCL2 ELISA Kit for Rattus norvegicus (Rat)

CCL2 ELISA Kit for Mus musculus (Mouse)