CCL5
CCL5全称为C-C基序趋化因子配体5，又称RANTES（调节激活正常T细胞表达和分泌因子），是免疫系统重要的信号分子。CCL5主要由T淋巴细胞、血小板和某些上皮细胞分泌，能够招募单核细胞、嗜酸性粒细胞等免疫细胞向炎症部位聚集。通过与细胞表面CCR1、CCR3和CCR5等受体结合，不仅参与抗病毒免疫反应，还与HIV病毒利用CCR5共受体入侵细胞的过程密切相关。在病理状态下，CCL5过度表达与类风湿性关节炎、动脉粥样硬化等慢性炎症疾病相关，同时被发现能通过调控肿瘤微环境促进乳腺癌、肺癌等恶性肿瘤的转移。
近年针对CCL5及其受体的药物开发取得进展，抗HIV药物马拉维诺正是通过阻断CCR5受体发挥作用。在癌症治疗领域，多个临床前研究证实抑制CCL5可降低肿瘤侵袭性，相关单克隆抗体药物已进入Ⅰ期临床试验。由于CCL5在抗感染与促肿瘤中存在双重作用，其靶向治疗需精准调控表达水平，目前科研团队正探索基于纳米载体的局部递送系统以平衡疗效与安全性。
热销产品
Recombinant Human C-C motif chemokine 5 (CCL5) (CSB-EP004800HUc7)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CCL5 Antibody (CSB-PA05955A0Rb)
验证数据
Western blot
All lanes: CCL5 antibody at 2µg/ml
Lane 1: EC109 whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/15000 dilution
Predicted band size: 10 kDa
Observed band size: 70 kDa
CCL5 Antibodies
CCL5 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA05955A0Rb | CCL5 Antibody | Human | ELISA, WB |
| CSB-PA05955B0Rb | CCL5 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA05959A0Rb | CCL5 Antibody | Human | ELISA, WB |
| CSB-PA040300 | CCL5 Antibody | Human,Mouse,Rat | IHC, ELISA |
CCL5 Proteins
CCL5 Proteins for Cavia porcellus (Guinea pig)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004800GU CSB-EP004800GU CSB-BP004800GU CSB-MP004800GU CSB-EP004800GU-B |
Recombinant Guinea pig C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004800HU CSB-BP004800HU CSB-MP004800HU CSB-EP004800HU-B |
Recombinant Human C-C motif chemokine 5 (CCL5) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP004800HUe0 | Recombinant Human C-C motif chemokine 5 (CCL5) | E.coli |
| CSB-EP004800HU | Recombinant Human C-C motif chemokine 5 (CCL5) | E.coli |
| CSB-AP000871HU | Recombinant Human C-C motif chemokine 5 protein (CCL5) | E.Coli |
| CSB-EP004800HUc7 | Recombinant Human C-C motif chemokine 5 (CCL5) | E.coli |
| CSB-EP004800HUg5 | Recombinant Human C-C motif chemokine 5 (CCL5) | E.coli |
| CSB-EP004800HUd7 | Recombinant Human C-C motif chemokine 5 (CCL5) | E.coli |
CCL5 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004800MO CSB-EP004800MO CSB-BP004800MO CSB-MP004800MO CSB-EP004800MO-B |
Recombinant Mouse C-C motif chemokine 5 (Ccl5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP001241MO | Recombinant Mouse C-C motif chemokine 5 protein (Ccl5) | E.Coli |
CCL5 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004800RA CSB-EP004800RA CSB-BP004800RA CSB-MP004800RA CSB-EP004800RA-B |
Recombinant Rat C-C motif chemokine 5 (Ccl5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004800BO CSB-EP004800BO CSB-BP004800BO CSB-MP004800BO CSB-EP004800BO-B |
Recombinant Bovine C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Sus scrofa (Pig)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP643672PI CSB-EP643672PI CSB-BP643672PI CSB-MP643672PI CSB-EP643672PI-B |
Recombinant Pig C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP808495DO CSB-EP808495DO CSB-BP808495DO CSB-MP808495DO CSB-EP808495DO-B |
Recombinant Dog C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Macaca mulatta (Rhesus macaque)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP814163MOW CSB-EP814163MOW CSB-BP814163MOW CSB-MP814163MOW CSB-EP814163MOW-B |
Recombinant Macaca mulatta C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Sigmodon hispidus (Hispid cotton rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP842062SZK CSB-EP842062SZK CSB-BP842062SZK CSB-MP842062SZK CSB-EP842062SZK-B |
Recombinant Sigmodon hispidus C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Felis catus (Cat) (Felis silvestris catus)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP844627CA CSB-EP844627CA CSB-BP844627CA CSB-MP844627CA CSB-EP844627CA-B |
Recombinant Cat C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Equus caballus (Horse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP847581HO CSB-EP847581HO CSB-BP847581HO CSB-MP847581HO CSB-EP847581HO-B |
Recombinant Horse C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 ELISA Kit
CCL5 ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-EL004800DO | Dog C-C motif chemokine 5(CCL5) ELISA kit | serum, plasma, tissue homogenates | 0.081 ng/mL |
CCL5 ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E17375h | Human C-C motif chemokine 5 (CCL5/D17S136E/SCYA5) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 2.307 pg/mL |
CCL5 ELISA Kit for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E09256m | Mouse regulated on activation in normal T-cell expressed and secreted,RANTES ELISA kit | serum, plasma, tissue homogenates | 0.039 ng/mL |
CCL5 ELISA Kit for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E07398r | Rat regulated on activation in normal T-cell expressed and secreted/C-C motif chemokine 5 (RANTES/CCL5) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 0.039 ng/mL |
