CCR2

C-C趋化因子受体2型（CCR2）是免疫系统中重要的信号传导蛋白，因其与CD192、ChemR13等别名广为人知。该受体主要分布于单核细胞、记忆T细胞表面，通过识别趋化因子CCL2等配体，引导免疫细胞向炎症或损伤部位定向迁移。CCR2的异常激活与多种疾病密切相关，例如动脉粥样硬化斑块中巨噬细胞浸润、类风湿性关节炎的滑膜炎症加剧，以及乳腺癌、胰腺癌的转移过程均存在其活跃表达。近年来，针对CCR2的药物开发成为热点，辉瑞公司开发的INCB3344曾进入银屑病二期试验，而艾伯维的ABT-129则在糖尿病肾病研究中展现出调节免疫微环境的潜力。尽管部分候选药物因疗效不足或脱靶效应终止研发，但新型双靶点抑制剂（如同时阻断CCR2/CCR5的cenicriviroc）在非酒精性脂肪性肝炎治疗中取得积极数据，为慢性炎症性疾病提供了新思路。

热销产品

Recombinant Human C-C chemokine receptor type 2 (CCR2) (Active) (CSB-CF004841HU)

验证数据

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CCR2 Recombinant Monoclonal Antibody (CSB-RA297464A0HU)

验证数据

IHC image of CSB-RA297464A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Human CC-Chemokine Receptor 2,CCR2 ELISA Kit (CSB-E14200h)

验证数据

货号：CSB-E14200h

规格：96T/48T

灵敏度：5.86 pg/mL

检测范围：23.44 pg/mL-1500 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

CCR2 Antibody

CCR2 Protein

CCR2 ELISA Kit

CCR2 Antibodies

CCR2 for Homo sapiens (Human)

产品货号	产品名称	种属反应性	应用类型
CSB-PA004841GA01HU	CCR2 Antibody	Human	ELISA,WB
CSB-PA006295	CCR2 Antibody	Human	WB, ELISA
CSB-PA171419	CCR2 Antibody	Human,Mouse	ELISA,WB,IHC
CSB-PA004841LA01HU	CCR2 Antibody	Human	ELISA, IF
CSB-RA297464A0HU	CCR2 Recombinant Monoclonal Antibody	Human	ELISA, IHC

CCR2 for Rattus norvegicus (Rat)

产品货号	产品名称	种属反应性	应用类型
CSB-PA006349	CCR2 Antibody	Rat, Human	WB, IF, ELISA

CCR2 Proteins

CCR2 Proteins for Homo sapiens (Human)

产品货号	产品名称	来源
CSB-YP004841HU1 CSB-EP004841HU1 CSB-BP004841HU1 CSB-MP004841HU1 CSB-EP004841HU1-B	Recombinant Human C-C chemokine receptor type 2 (CCR2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF004841HU	Recombinant Human C-C chemokine receptor type 2 (CCR2) (Active)	in vitro E.coli expression system
CSB-MP004841HU	Recombinant Human C-C chemokine receptor type 2 (CCR2)-VLPs	Mammalian cell

CCR2 Proteins for Mus musculus (Mouse)

产品货号	产品名称	来源
CSB-YP004841MO1 CSB-BP004841MO1 CSB-MP004841MO1 CSB-EP004841MO1-B	Recombinant Mouse C-C chemokine receptor type 2 (Ccr2), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF004841MO	Recombinant Mouse C-C chemokine receptor type 2 (Ccr2)	in vitro E.coli expression system

CCR2 Proteins for Macaca mulatta (Rhesus macaque)

产品货号	产品名称	来源
CSB-YP004841MOW1 CSB-EP004841MOW1 CSB-BP004841MOW1 CSB-MP004841MOW1 CSB-EP004841MOW1-B	Recombinant Macaca mulatta (Rhesus macaque) C-C chemokine receptor type 2 (CCR2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF004841MOW	Recombinant Macaca mulatta (Rhesus macaque) C-C chemokine receptor type 2 (CCR2)	in vitro E.coli expression system

CCR2 Proteins for Rattus norvegicus (Rat)

产品货号	产品名称	来源
CSB-YP004841RA1 CSB-EP004841RA1 CSB-BP004841RA1 CSB-MP004841RA1 CSB-EP004841RA1-B	Recombinant Rat C-C chemokine receptor type 2 (Ccr2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF004841RA	Recombinant Rat C-C chemokine receptor type 2 (Ccr2)	in vitro E.coli expression system

CCR2 Proteins for Arabidopsis thaliana (Mouse-ear cress)

产品货号	产品名称	来源
CSB-YP525710DOA CSB-EP525710DOA CSB-BP525710DOA CSB-MP525710DOA CSB-EP525710DOA-B	Recombinant Arabidopsis thaliana Serine/threonine-protein kinase-like protein CCR2 (CCR2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli