CCR3
CCR3（C-C趋化因子受体3）是一种主要分布于嗜酸性粒细胞、嗜碱性粒细胞及Th2细胞的G蛋白偶联受体，也被称为CD193。该蛋白通过与Eotaxin等趋化因子结合，调控免疫细胞向炎症部位迁移，尤其在过敏性疾病中扮演核心角色。研究发现，其在哮喘患者的呼吸道、过敏性鼻炎鼻黏膜及特应性皮炎皮损部位异常活跃，与嗜酸性粒细胞浸润直接相关。近年还发现某些实体瘤微环境中CCR3高表达，可能参与肿瘤免疫逃逸，例如结肠癌中CCR3信号可能促进血管生成。
针对CCR3的药物研发曾聚焦于小分子拮抗剂，如GSK766994等早期候选药物在临床试验中因疗效不足或脱靶效应未能突破。目前策略转向联合疗法，例如将CCR3抑制剂与抗IgE抗体奥马珠单抗联用，或开发双功能抗体同时阻断CCR3与IL-5通路。2022年跨国药企公布的临床前数据显示，新型变构抑制剂可选择性抑制嗜酸性粒细胞迁移而不影响其他免疫细胞，为减少副作用提供新方向。但该靶点成药性挑战仍存，需进一步验证其在复杂炎症网络中的调控机制。
热销产品
CCR3 Antibody (CSB-PA004842LA01HU)
验证数据
Western Blot
Positive WB detected in: Mouse liver tissue
All lanes: CCR3 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
predicted band size: 42, 44 kDa
observed band size: 42 kDa
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA004842LA01HU at dilution of 1:100
Immunofluorescent analysis of A549 cells using CSB-PA004842LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
CCR3 Antibodies
CCR3 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA005330 | CCR3 Antibody | Human | WB, ELISA |
| CSB-PA262645 | CCR3 Antibody | Human | ELISA,WB,IHC |
| CSB-PA793937 | CCR3 Antibody | Human | ELISA,WB,IHC |
| CSB-PA004842LA01HU | CCR3 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA004842LB01HU | CCR3 Antibody, HRP conjugated | Human | ELISA |
CCR3 Proteins
CCR3 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004842HU1 CSB-EP004842HU1 CSB-BP004842HU1 CSB-MP004842HU1 CSB-EP004842HU1-B |
Recombinant Human C-C chemokine receptor type 3 (CCR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004842HU | Recombinant Human C-C chemokine receptor type 3 (CCR3) | in vitro E.coli expression system |
| CSB-CF004842HUl3 | Recombinant Human C-C chemokine receptor type 3 (CCR3) | in vitro E.coli expression system |
CCR3 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004842MO1 CSB-EP004842MO1 CSB-BP004842MO1 CSB-MP004842MO1 CSB-EP004842MO1-B |
Recombinant Mouse Probable C-C chemokine receptor type 3 (Ccr3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004842MO | Recombinant Mouse Probable C-C chemokine receptor type 3 (Ccr3) | in vitro E.coli expression system |
CCR3 Proteins for Macaca mulatta (Rhesus macaque)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004842MOW1 CSB-EP004842MOW1 CSB-BP004842MOW1 CSB-MP004842MOW1 CSB-EP004842MOW1-B |
Recombinant Macaca mulatta (Rhesus macaque) C-C chemokine receptor type 3 (CCR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004842MOW | Recombinant Macaca mulatta (Rhesus macaque) C-C chemokine receptor type 3 (CCR3) | in vitro E.coli expression system |
CCR3 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004842RA1 CSB-EP004842RA1 CSB-BP004842RA1 CSB-MP004842RA1 CSB-EP004842RA1-B |
Recombinant Rat C-C chemokine receptor type 3 (Ccr3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004842RA | Recombinant Rat C-C chemokine receptor type 3 (Ccr3) | in vitro E.coli expression system |
CCR3 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004842DSU1 CSB-EP004842DSU1 CSB-BP004842DSU1 CSB-MP004842DSU1 CSB-EP004842DSU1-B |
Recombinant Chlorocebus aethiops C-C chemokine receptor type 3 (CCR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004842DSU | Recombinant Chlorocebus aethiops C-C chemokine receptor type 3 (CCR3) | in vitro E.coli expression system |
CCR3 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP714527DO1 CSB-EP714527DO1 CSB-BP714527DO1 CSB-MP714527DO1 CSB-EP714527DO1-B |
Recombinant Dog C-C chemokine receptor type 3 (CCR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF714527DO | Recombinant Dog C-C chemokine receptor type 3 (CCR3) | in vitro E.coli expression system |
CCR3 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP858985MOV1 CSB-EP858985MOV1 CSB-BP858985MOV1 CSB-MP858985MOV1 CSB-EP858985MOV1-B |
Recombinant Macaca fascicularis C-C chemokine receptor type 3 (CCR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF858985MOV | Recombinant Macaca fascicularis C-C chemokine receptor type 3 (CCR3) | in vitro E.coli expression system |
CCR3 Proteins for Arabidopsis thaliana (Mouse-ear cress)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP878633DOA CSB-EP878633DOA CSB-BP878633DOA CSB-MP878633DOA CSB-EP878633DOA-B |
Recombinant Arabidopsis thaliana Putative serine/threonine-protein kinase-like protein CCR3 (CCR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
