CCR7
CCR7全称为C-C趋化因子受体7型，也被称为CD197，是趋化因子受体家族的重要成员。CCR7通过与配体CCL19和CCL21结合，引导淋巴细胞定向迁移至次级淋巴器官，对维持免疫系统稳态具有关键作用。CCR7在树突状细胞成熟过程中表达上调，帮助抗原呈递细胞精准定位至淋巴结，从而启动适应性免疫应答。临床上，CCR7的异常表达与多种疾病密切相关，在乳腺癌、黑色素瘤等恶性肿瘤中，癌细胞通过激活该受体实现淋巴结转移；而在类风湿性关节炎患者中，CCR7过度活化会促使炎症细胞浸润关节滑膜。针对CCR7的药物开发聚焦于肿瘤免疫治疗领域，已有小分子拮抗剂在动物模型中成功阻断肿瘤转移，但进入临床阶段的候选药物仍较少。利用单克隆抗体阻断CCR7-配体相互作用的新型疗法，在治疗自身免疫性疾病方面展现出潜在价值，相关研究正在从实验室向转化医学推进。
热销产品
Recombinant Human C-C chemokine receptor type 7 (CCR7), partial (CSB-EP004846HU1)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CCR7 Antibody (CSB-PA004846LA01HU)
验证数据
Immunohistochemistry analysis of human lung tissue using CSB-PA004846LA01HU at dilution of 1:100
Immunocytochemistry analysis of human tonsil tissue using CSB-PA004846LA01HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA004846LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
CCR7 Antibodies
CCR7 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA006996 | CCR7 Antibody | Human,Monkey | WB, IF, ELISA |
| CSB-PA265889 | CCR7 Antibody | Human | ELISA,WB |
| CSB-PA004846LA01HU | CCR7 Antibody | Human | ELISA, IHC, IF |
| CSB-PA004846LB01HU | CCR7 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA004846LC01HU | CCR7 Antibody, FITC conjugated | Human | |
| CSB-PA004846LD01HU | CCR7 Antibody, Biotin conjugated | Human | ELISA |
CCR7 Proteins
CCR7 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004846HU1 CSB-BP004846HU1 CSB-MP004846HU1 CSB-EP004846HU1-B |
Recombinant Human C-C chemokine receptor type 7 (CCR7), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004846HU | Recombinant Human C-C chemokine receptor type 7 (CCR7) | in vitro E.coli expression system |
| CSB-EP004846HU1 | Recombinant Human C-C chemokine receptor type 7 (CCR7), partial | E.coli |
| CSB-CF004846HUa0 | Recombinant Human C-C chemokine receptor type 7 (CCR7) | in vitro E.coli expression system |
CCR7 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004846MO1 CSB-EP004846MO1 CSB-BP004846MO1 CSB-MP004846MO1 CSB-EP004846MO1-B |
Recombinant Mouse C-C chemokine receptor type 7 (Ccr7), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004846MO | Recombinant Mouse C-C chemokine receptor type 7 (Ccr7) | in vitro E.coli expression system |
CCR7 Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP711736BO CSB-EP711736BO CSB-BP711736BO CSB-MP711736BO CSB-EP711736BO-B |
Recombinant Bovine C-C chemokine receptor type 7 (CCR7), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
