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CCR8

CCR8,即C-C基序趋化因子受体8,别名CD198、ChemR1、CKRL1、CKR-L1、CY6、GPRCL1、GPRCY6、GPR-CY6、TER-1等。CCR8是一种七次跨膜G蛋白偶联受体,属于趋化因子受体C-C亚家族。CCR8的作用机制涉及与其配体CCL1、CCL8、CCL16和CCL18的结合,其中CCL1是其主要配体。这些相互作用参与了多种肿瘤的发展进程及介导肿瘤的免疫逃逸。CCR8主要在肿瘤微环境中的调节性T细胞(Treg)上特异性高表达,而在周围正常组织和外周血中低表达,因此CCR8可以作为Treg细胞的一种特异性标志物,是一种有潜力的治疗靶点和生物标志物。CCR8的高表达与多种癌症相关,包括结直肠癌、乳腺癌、胃癌等,被认为是肿瘤部位Treg的潜在特异性标记物,是极具潜力的肿瘤免疫靶点。

热销产品

Recombinant Human C-C chemokine receptor type 8 (CCR8) (CSB-CF004847HU)

验证数据

CSB-CF004847HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CCR8 Recombinant Monoclonal Antibody (CSB-RA004847A1HU)

验证数据

CSB-RA004847A1HU

Untransfected HEK293T cells surface (green line) and transfected Human CCR8 HEK293T stable cells surface (red line) were stained with anti-CCR8 antibody (2µg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CCR8 Recombinant Monoclonal Antibody (CSB-RA004847MA3HU)

验证数据

CSB-RA004847MA3HU

Untransfected CHO-K1 cells surface(green line) and transfected Human CCR8 CHO-K1 stable cells surface (red line) were stained with anti-CCR8 antibody (2µg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CSB-RA004847MA3HU

The Binding Activity of CCR8 with Anti-CCR8 recombinant antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CCR8 (CSB-MP004847HU) at 5 μg/mL can bind Anti-CCR8 recombinant antibody, the EC50 is 11.20-15.63 ng/mL.

CCR8 Antibodies

CCR8 for Homo sapiens (Human)

CCR8 Proteins

CCR8 Proteins for Homo sapiens (Human)

CCR8 Proteins for Mus musculus (Mouse)

CCR8 Proteins for Macaca mulatta (Rhesus macaque)