Your Good Partner in Biology Research

CDH17

CDH17,即钙粘蛋白17,别名LI-cadherin。CDH17是一种7D-cadherin家族的成员,其胞外域由EC1-EC7七个重复序列构成,胞内域含18-20个氨基酸。CDH17的功能是作为多肽转运器和细胞粘附分子来维持上皮组织的完整性。CDH17的粘附机制与典型cadherin不同,它不需要与α和β-catenins复合,能在不与其他细胞质成分相互作用的情况下保持粘合功能。CDH17在正常人类细胞中仅在小肠和结肠中高表达,而在肝脏、心脏和肾脏等其他组织中不表达或低表达。然而,在肿瘤组织中,CDH17在胃、胰腺、肝、食道、胆管癌和结直肠癌中过表达,其表达异常与肿瘤的形成和转移密切相关。CDH17是消化系统恶性肿瘤的潜在诊断标志物和治疗靶点。

热销产品

Recombinant Human Cadherin-17 (CDH17), partial (Active) (CSB-MP613267HU)

验证数据

CSB-MP613267HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP613267HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CDH17 at 2μg/mL can bind Anti-CDH17 recombinant antibody (CSB-RA613267MA1HU), the EC50 is 3.095 to 4.451 ng/mL.

CDH17 Recombinant Monoclonal Antibody (CSB-RA613267MA1HU)

验证数据

CSB-RA613267MA1HU

The Binding Activity of Human CDH17 with Anti-CDH17 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CDH17 (CSB-MP613267HU) at 2 μg/mL can bind Anti-CDH17 recombinant antibody, the EC50 is 3.095-4.451 ng/mL.

CSB-RA613267MA1HU

Untransfected HEK293T cells surface (green line) and transfected Human CDH17 HEK293T stable cells surface (red line) were stained with anti-CDH17 antibody (2µg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CDH17 Antibodies

CDH17 for Homo sapiens (Human)

CDH17 Proteins

CDH17 Proteins for Rattus norvegicus (Rat)

CDH17 Proteins for Homo sapiens (Human)

CDH17 Proteins for Mus musculus (Mouse)