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CDK5

CDK5,即细胞周期素依赖蛋白激酶5,别名TPKII。CDK5最早是从牛脑组织中分离和筛选得到的,与cdc2和cdk2同源性分别为58%和62%。CDK5是一种非典型的丝氨酸/苏氨酸激酶,需要与其激活因子p35、p39或p25结合才具有激酶活性。这些激活因子与CDK5结合后,主要在细胞膜、细胞质和核周区域发挥作用。CDK5在多种生物学过程中发挥作用,包括神经细胞迁移、轴突导向、突触发生与传递,以及细胞凋亡和细胞存活的调控。在阿尔茨海默病(AD)中,CDK5能够磷酸化tau蛋白,导致其过度磷酸化。

热销产品

Recombinant Human Cyclin-dependent kinase 5 (CDK5) (CSB-EP005067HUe1)

验证数据

CSB-EP005067HUe1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CDK5 Antibody (CSB-PA547925)

验证数据

CSB-PA547925

The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA547925(CDK5 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)

CSB-PA547925

The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA547925(CDK5 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)

CSB-PA547925

Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Jurkat cells, NIH/3T3 cells, Primary antibody: CSB-PA547925(CDK5 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute

CDK5 Antibodies

CDK5 for Homo sapiens (Human)

CDK5 Proteins

CDK5 Proteins for Homo sapiens (Human)