CFD
补体因子D（Complement Factor D，CFD）又称脂肪细胞特异性分泌因子Adipsin，是补体系统旁路途径的核心蛋白酶。CFD由脂肪细胞及肝脏合成，在血液中以低浓度持续存在，通过特异性切割补体因子B激活补体级联反应，形成C3转化酶放大炎症信号。CFD异常表达与年龄相关性黄斑变性密切相关，其过度激活会导致视网膜色素上皮细胞损伤，全球约15%的AMD患者存在CFD基因变异。在代谢性疾病领域，CFD水平升高可加剧胰岛素抵抗，与2型糖尿病肾病进展呈正相关。目前针对CFD的单克隆抗体药物APL-2已完成二期临床试验，通过抑制补体旁路途径显著降低地理萎缩患者的病灶扩大速度。CFD抑制剂还被探索用于阵发性睡眠性血红蛋白尿症和IgA肾病的治疗，已有小分子化合物进入临床前研究阶段。
热销产品
CFD Antibody (CSB-PA005271ESR2HU)
验证数据
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA005271ESR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA005271ESR2HU at dilution of 1:100
CFD Antibodies
CFD for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA005271ESR2HU | CFD Antibody | Human | ELISA, IHC |
CFD Proteins
CFD Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP005271RA | Recombinant Rat Complement factor D (Cfd) | Yeast |
| CSB-EP005271RA | Recombinant Rat Complement factor D (Cfd) | E.coli |
| CSB-BP005271RA CSB-EP005271RA-B |
Recombinant Rat Complement factor D (Cfd) | Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP005271RA | Recombinant Rat Complement factor D (Cfd) | Mammalian cell |
| CSB-MP005271RAd9 | Recombinant Rat Complement factor D (Cfd) | Mammalian cell |
CFD Proteins for Sus scrofa (Pig)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP005271PI CSB-EP005271PI CSB-BP005271PI CSB-MP005271PI CSB-EP005271PI-B |
Recombinant Pig Complement factor D (CFD) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CFD Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP005271HU CSB-EP005271HU CSB-BP005271HU CSB-MP005271HU CSB-EP005271HU-B |
Recombinant Human Complement factor D (CFD) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CFD Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP005271MO CSB-EP005271MO CSB-BP005271MO CSB-MP005271MO CSB-EP005271MO-B |
Recombinant Mouse Complement factor D (Cfd) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CFD Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP660982BO CSB-EP660982BO CSB-BP660982BO CSB-MP660982BO CSB-EP660982BO-B |
Recombinant Bovine Complement factor D (CFD) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CFD ELISA Kit
CFD ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E14369h | Human Adipsin ELISA Kit | serum, plasma, tissue homogenates | 0.078 ng/mL |
