COL2A1

COL2A1全称为胶原蛋白II型α1链，是构成软骨组织的主要成分之一。这种胶原蛋白在胚胎发育阶段主导骨骼和关节的形成，成年后则集中分布于眼睛玻璃体、椎间盘和关节软骨中，通过交织成网状结构维持组织的弹性和承重能力。COL2A1异常表达或结构缺陷会直接影响软骨完整性，例如在斯蒂克勒综合征中，患者因胶原纤维排列紊乱出现视网膜脱离和关节病变；而在遗传性骨关节炎中，COL2A1的突变会导致软骨过早退化，引发关节疼痛和活动受限。近年来针对II型胶原蛋白的研究聚焦于再生医学领域，例如利用三维生物支架结合患者自体干细胞，促进损伤软骨的修复。此外，一些基于胶原蛋白片段的多肽药物已进入临床试验阶段，旨在通过调节炎症反应延缓关节退变。自然界中的鲨鱼软骨提取物也曾被探索用于辅助治疗，但其疗效尚未得到充分验证。

热销产品

COL2A1 Antibody (CSB-PA005739ESR2HU)

验证数据

Western blot
All lanes: Collagen alpha-1 (II) chain antibody at 10μg/ml + 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 142, 135, 30 kDa
Observed band size: 142 kDa

Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA005739ESR2HU at dilution of 1:100

Human Collagen alpha-1(II) chain (COL2A1) ELISA kit (CSB-EL005739HU)

验证数据

货号：CSB-EL005739HU

规格：96T/48T

灵敏度：0.078 ng/mL

检测范围：0.312 ng/mL-20 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

COL2A1 Antibody

COL2A1 Protein

COL2A1 ELISA Kit

COL2A1 Antibodies

COL2A1 for Homo sapiens (Human)

产品货号	产品名称	种属反应性	应用类型
CSB-PA005739ESR2HU	COL2A1 Antibody	Human	ELISA, WB, IHC
CSB-PA005739ESR1HU	COL2A1 Antibody	Human	ELISA, IHC
CSB-PA593434	COL2A1 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA255449	COL2A1 Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA001745	COL2A1 Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA437981	COL2A1 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-MA964039	COL2A1 Monoclonal Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-MA217046	COL2A1 Monoclonal Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-MA768371	COL2A1 Monoclonal Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-MA186977	COL2A1 Monoclonal Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-MA397245	COL2A1 Monoclonal Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA17772A0Rb	COL2A1 Antibody	Human	ELISA, IHC
CSB-PA17772B0Rb	COL2A1 Antibody, HRP conjugated	Human	ELISA
CSB-PA17772C0Rb	COL2A1 Antibody, FITC conjugated	Human
CSB-PA17772D0Rb	COL2A1 Antibody, Biotin conjugated	Human	ELISA

COL2A1 Proteins

COL2A1 Proteins for Mus musculus (Mouse)

产品货号	产品名称	来源
CSB-YP005739MO CSB-EP005739MO CSB-BP005739MO CSB-MP005739MO CSB-EP005739MO-B	Recombinant Mouse Collagen alpha-1 (II) chain (Col2a1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

COL2A1 Proteins for Bos taurus (Bovine)

产品货号	产品名称	来源
CSB-YP005739BO CSB-EP005739BO CSB-BP005739BO CSB-MP005739BO CSB-EP005739BO-B	Recombinant Bovine Collagen alpha-1 (II) chain (COL2A1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

COL2A1 Proteins for Homo sapiens (Human)

产品货号	产品名称	来源
CSB-YP005739HU CSB-EP005739HU CSB-BP005739HU CSB-MP005739HU CSB-EP005739HU-B	Recombinant Human Collagen alpha-1 (II) chain (COL2A1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

COL2A1 Proteins for Rattus norvegicus (Rat)

产品货号	产品名称	来源
CSB-YP005739RA CSB-EP005739RA CSB-BP005739RA CSB-MP005739RA CSB-EP005739RA-B	Recombinant Rat Collagen alpha-1 (II) chain (Col2a1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

COL2A1 Proteins for Gallus gallus (Chicken)

产品货号	产品名称	来源
CSB-YP005739CH CSB-EP005739CH CSB-BP005739CH CSB-MP005739CH CSB-EP005739CH-B	Recombinant Chicken Collagen alpha-1 (II) chain (COL2A1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

COL2A1 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

产品货号	产品名称	来源
CSB-YP747407XBF CSB-EP747407XBF CSB-BP747407XBF CSB-MP747407XBF CSB-EP747407XBF-B	Recombinant Xenopus tropicalis Collagen alpha-1 (II) chain (col2a1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

COL2A1 Proteins for Xenopus laevis (African clawed frog)

产品货号	产品名称	来源
CSB-YP838630XBE CSB-EP838630XBE CSB-BP838630XBE CSB-MP838630XBE CSB-EP838630XBE-B	Recombinant Xenopus laevis Collagen alpha-1 (II) chain (col2a1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli