CRLF2
CDLF2，即细胞因子受体样因子2，别名CRLF2。它是由人类CRLF2基因编码的I型细胞因子受体家族成员。CRLF2蛋白是胸腺基质淋巴生成素（TSLP）的受体，与白细胞介素7受体（IL7R）一起，能够激活STAT3、STAT5和JAK2途径，这些途径控制着细胞增殖和造血系统发育等过程。CRLF2的作用机制涉及与TSLP和IL7R形成功能性复合体，通过激活JAK-STAT信号通路来刺激细胞增殖。CRLF2在正常B淋巴细胞的发育中起重要作用，但在急性淋巴细胞白血病（ALL）中，CRLF2的过表达或重排与疾病的发生发展有关，尤其是在Ph样ALL（费城染色体样急性淋巴细胞白血病）中，CRLF2的重排导致细胞表面CRLF2高表达，刺激前B淋巴细胞增殖，与不良预后相关。
热销产品
CRLF2 Antibody (CSB-PA005983ESR1HU)
验证数据
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA005983ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA005983ESR1HU at dilution of 1:100
CRLF2 Antibodies
CRLF2 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA905549 | CRLF2 Antibody | Human | ELISA,IHC |
| CSB-PA976066 | CRLF2 Antibody | Human | ELISA,WB,IHC |
| CSB-PA005983ESR1HU | CRLF2 Antibody | Human | ELISA, IHC |
CRLF2 Proteins
CRLF2 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP005983MO CSB-EP005983MO CSB-BP005983MO CSB-MP005983MO CSB-EP005983MO-B |
Recombinant Mouse Cytokine receptor-like factor 2 (Crlf2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CRLF2 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP005983RA CSB-EP005983RA CSB-BP005983RA CSB-MP005983RA CSB-EP005983RA-B |
Recombinant Rat Cytokine receptor-like factor 2 (Crlf2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CRLF2 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP005983HU CSB-EP005983HU CSB-BP005983HU CSB-MP005983HU CSB-EP005983HU-B |
Recombinant Human Cytokine receptor-like factor 2 (CRLF2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
