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CSF3R

CSF3R全称为集落刺激因子3受体,又称粒细胞集落刺激因子受体(G-CSFR),属于I型细胞因子受体超家族。CSF3R由胞外配体结合区、跨膜结构域及胞内信号传导域组成,主要通过与粒细胞集落刺激因子(G-CSF)结合,调控中性粒细胞的增殖、分化及存活。在血液系统疾病中,CSF3R基因突变与先天性中性粒细胞减少症、慢性中性粒细胞白血病密切相关,特别是截短型突变可导致受体持续激活,引发髓系肿瘤。近年来研究发现,约30%的慢性中性粒细胞白血病患者携带该基因突变,成为诊断分型的重要标志。针对CSF3R信号异常,JAK抑制剂鲁索替尼已用于携带CSF3R-T618I突变患者的临床治疗,而重组G-CSF制剂如培非格司亭则广泛用于化疗后粒细胞缺乏的挽救治疗。目前针对该靶点的单克隆抗体药物及小分子激酶抑制剂已进入临床试验阶段,为髓系肿瘤精准治疗提供新方向。

热销产品

Recombinant Human Granulocyte colony-stimulating factor receptor (CSF3R), partial (CSB-MP860321HUi10)

验证数据

CSB-MP860321HUi10

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSF3R Recombinant Monoclonal Antibody (CSB-RA860321MA1HU)

验证数据

CSB-RA860321MA1HU

IHC image of CSB-RA860321MA1HU diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA860321MA1HU

IHC image of CSB-RA860321MA1HU diluted at 1:100 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSF3R Antibodies

CSF3R for Homo sapiens (Human)

CSF3R Proteins

CSF3R Proteins for Mus musculus (Mouse)

CSF3R Proteins for Homo sapiens (Human)