CX3CL1
CX3CL1蛋白全称为C-X3-C基序趋化因子配体1，别名CXC3。这种独特的趋化因子以跨膜形式存在于细胞表面，同时可被酶切释放为可溶形式，兼具细胞黏附和趋化双重功能。CX3CL1通过结合CX3CR1受体，在单核细胞、T细胞和神经小胶质细胞的迁移中起关键作用，尤其在神经免疫交互中表现突出。
CX3CL1与阿尔茨海默病、帕金森病等神经退行性疾病密切相关，脑内小胶质细胞通过CX3CL1-CX3CR1轴调控神经炎症进程。在心血管领域，CX3CL1参与动脉粥样硬化斑块形成，促进单核细胞向血管壁浸润。针对该通路的药物开发已进入临床试验阶段，例如E6011单抗通过阻断CX3CL1-CX3CR1相互作用，在类风湿性关节炎和狼疮性肾炎治疗中显示出潜力。阿尔茨海默病动物模型中，抑制该通路可减少β淀粉样蛋白沉积，为神经退行性疾病治疗提供了新方向。
热销产品
Recombinant Human Fractalkine (CX3CL1), partial, Biotinylated (CSB-MP006235HU-B)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CX3CL1 Antibody (CSB-PA06087A0Rb)
验证数据
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA06087A0Rb at dilution of 1:100
Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA06087A0Rb at dilution of 1:100
Immunofluorescent analysis of Hela cells cells using CSB-PA06087A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
CX3CL1 Antibodies
CX3CL1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA06087A0Rb | CX3CL1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA006235GA01HU | CX3CL1 Antibody | Human | ELISA,WB |
| CSB-PA005564 | CX3CL1 Antibody | Human | WB, ELISA |
| CSB-PA092112 | CX3CL1 Antibody | Human,Mouse,Rat | ELISA,IHC |
CX3CL1 Proteins
CX3CL1 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP006235HU CSB-EP006235HU CSB-BP006235HU CSB-MP006235HU CSB-EP006235HU-B |
Recombinant Human Fractalkine (CX3CL1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP006235HU(F) | Recombinant Human Fractalkine (CX3CL1), partial | E.coli |
| CSB-AP000801HU | Recombinant Human Fractalkine protein (CX3CL1), partial (Active) | E.Coli |
| CSB-MP006235HU-B | Recombinant Human Fractalkine (CX3CL1), partial, Biotinylated | Mammalian cell |
CX3CL1 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP006235MO1 CSB-EP006235MO1 CSB-BP006235MO1 CSB-MP006235MO1 CSB-EP006235MO1-B |
Recombinant Mouse Fractalkine (Cx3cl1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP001211MO | Recombinant Mouse Fractalkine protein (Cx3cl1), partial (Active) | E.Coli |
| CSB-CF006235MO | Recombinant Mouse Fractalkine (Cx3cl1) | in vitro E.coli expression system |
CX3CL1 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP006235RA1 CSB-EP006235RA1 CSB-BP006235RA1 CSB-MP006235RA1 CSB-EP006235RA1-B |
Recombinant Rat Fractalkine (Cx3cl1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP001511RA | Recombinant Rat Fractalkine protein (Cx3cl1), partial (Active) | E.Coli |
| CSB-CF006235RA | Recombinant Rat Fractalkine (Cx3cl1) | in vitro E.coli expression system |
CX3CL1 ELISA Kit
CX3CL1 ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E04558h | Human Fractalkine,FK ELISA Kit | serum, plasma, tissue homogenates | 0.078 ng/mL |
CX3CL1 ELISA Kit for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E04559m | Mouse Fractalkine,FK ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 31.25 pg/mL |
CX3CL1 ELISA Kit for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E04560r | Rat Fractalkine,FK ELISA Kit | serum, plasma | 0.078 ng/mL |
