CX3CR1

CX3CR1全称为CX3C趋化因子受体1，也被称为Fractalkine受体或G蛋白偶联受体13。这种蛋白主要分布在单核细胞、小胶质细胞和自然杀伤细胞表面，通过与其配体Fractalkine的相互作用，调控免疫细胞的迁移与黏附功能，尤其在炎症反应和免疫监视中发挥重要作用。研究发现，CX3CR1介导的细胞间通讯与神经退行性疾病密切相关，例如阿尔茨海默病患者脑内小胶质细胞的异常激活便与其功能失调存在关联。此外，该受体在动脉粥样硬化斑块形成过程中参与单核细胞的浸润，与心血管疾病的发展密切相关。
近年来，针对CX3CR1的药物开发聚焦于炎症性疾病治疗领域。部分小分子抑制剂已在动物模型中展现出抑制神经炎症和延缓动脉斑块进展的效果。临床前研究还发现，阻断CX3CR1可能缓解类风湿性关节炎的关节损伤。目前已有单克隆抗体类药物进入早期临床试验阶段，尝试通过调控免疫细胞迁移来治疗多发性硬化等自身免疫疾病。与此同时，该受体在肿瘤微环境中的双重作用也引起关注，既有研究支持其促进肿瘤免疫逃逸，也有证据表明可能增强抗肿瘤免疫应答，这一矛盾特性为靶向治疗带来挑战。

热销产品

CX3CR1 Antibody (CSB-PA006236LA01HU)

验证数据

Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA006236LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA006236LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Human CX3C-chemokine receptor 1,CX3CR1 ELISA Kit (CSB-E09942h)

验证数据

货号：CSB-E09942h

规格：96T/48T

灵敏度：7.8 pg/mL

检测范围：31.25 pg/mL-2000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

CX3CR1 Antibody

CX3CR1 Protein

CX3CR1 ELISA Kit

CX3CR1 Antibodies

CX3CR1 for Homo sapiens (Human)

产品货号	产品名称	种属反应性	应用类型
CSB-PA006236GA01HU	CX3CR1 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA004776	CX3CR1 Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA007487	CX3CR1 Antibody	Human	IHC, IF, ELISA
CSB-PA135132	CX3CR1 Antibody	Human	ELISA,WB
CSB-PA080771	CX3CR1 Antibody	Human	ELISA,WB
CSB-PA006236LA01HU	CX3CR1 Antibody	Human	ELISA, IHC, IF
CSB-PA006236LB01HU	CX3CR1 Antibody, HRP conjugated	Human	ELISA
CSB-PA006236LC01HU	CX3CR1 Antibody, FITC conjugated	Human
CSB-PA006236LD01HU	CX3CR1 Antibody, Biotin conjugated	Human	ELISA

CX3CR1 Proteins

CX3CR1 Proteins for Homo sapiens (Human)

产品货号	产品名称	来源
CSB-YP006236HU1 CSB-EP006236HU1 CSB-BP006236HU1 CSB-MP006236HU1 CSB-EP006236HU1-B	Recombinant Human CX3C chemokine receptor 1 (CX3CR1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF006236HU	Recombinant Human CX3C chemokine receptor 1 (CX3CR1)	in vitro E.coli expression system
CSB-MP006236HU	Recombinant Human CX3C chemokine receptor 1 (CX3CR1)-VLPs	Mammalian cell

CX3CR1 Proteins for Bos taurus (Bovine)

产品货号	产品名称	来源
CSB-YP006236BO1 CSB-EP006236BO1 CSB-BP006236BO1 CSB-MP006236BO1 CSB-EP006236BO1-B	Recombinant Bovine CX3C chemokine receptor 1 (CX3CR1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF006236BO	Recombinant Bovine CX3C chemokine receptor 1 (CX3CR1)	in vitro E.coli expression system

CX3CR1 Proteins for Rattus norvegicus (Rat)

产品货号	产品名称	来源
CSB-YP006236RA1 CSB-EP006236RA1 CSB-BP006236RA1 CSB-MP006236RA1 CSB-EP006236RA1-B	Recombinant Rat CX3C chemokine receptor 1 (Cx3cr1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF006236RA	Recombinant Rat CX3C chemokine receptor 1 (Cx3cr1)	in vitro E.coli expression system

CX3CR1 Proteins for Oryctolagus cuniculus (Rabbit)

产品货号	产品名称	来源
CSB-YP644447RB1 CSB-EP644447RB1 CSB-BP644447RB1 CSB-MP644447RB1 CSB-EP644447RB1-B	Recombinant Rabbit CX3C chemokine receptor 1 (CX3CR1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF644447RB	Recombinant Rabbit CX3C chemokine receptor 1 (CX3CR1)	in vitro E.coli expression system

CX3CR1 Proteins for Mus musculus (Mouse)

产品货号	产品名称	来源
CSB-YP897445MO1 CSB-EP897445MO1 CSB-BP897445MO1 CSB-MP897445MO1 CSB-EP897445MO1-B	Recombinant Mouse CX3C chemokine receptor 1 (Cx3cr1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF897445MO	Recombinant Mouse CX3C chemokine receptor 1 (Cx3cr1)	in vitro E.coli expression system