CXCL13

CXCL13的全称为C-X-C基序趋化因子13，也被称为B淋巴细胞趋化因子（BLC）或BCA-1。该蛋白在免疫系统中扮演重要角色，能够特异性引导B细胞和滤泡辅助T细胞向淋巴组织中的特定区域迁移，例如促进生发中心的形成，从而增强抗体产生和长期免疫记忆。CXCL13的异常表达与多种疾病密切相关，例如类风湿性关节炎、系统性红斑狼疮等自身免疫疾病中常出现其水平升高，而在某些B细胞淋巴瘤中，CXCL13可能通过持续激活微环境促进肿瘤发展。此外，中枢神经系统感染莱姆病时，脑脊液中CXCL13浓度显著上升，已成为辅助诊断的重要生物标志物。
近年来针对CXCL13的药物研发主要聚焦于阻断其与受体CXCR5的结合。单克隆抗体类药物已进入早期临床研究阶段，拟用于治疗自身免疫性疾病及部分实体瘤。另有小分子抑制剂通过干扰CXCL13介导的细胞迁移途径，在动物模型中显示出抑制炎症和肿瘤转移的效果。这些进展为相关疾病的精准治疗提供了新方向。

热销产品

Recombinant Human C-X-C motif chemokine 13 (CXCL13) (CSB-EP006243HU)

验证数据

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CXCL13 Antibody (CSB-PA06139A0Rb)

验证数据

Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA06139A0Rb at dilution of 1:100

Human B-Lymphocyte Chemoattractant 1,BLC-1 ELISA Kit (CSB-E10019h)

验证数据

货号：CSB-E10019h

规格：96T/48T

灵敏度：19.5 pg/mL

检测范围：78 pg/mL-5000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

CXCL13 Antibody

CXCL13 Protein

CXCL13 ELISA Kit

CXCL13 Antibodies

CXCL13 for Homo sapiens (Human)

产品货号	产品名称	种属反应性	应用类型
CSB-PA006243GA01HU	CXCL13 Antibody	Human	ELISA,WB
CSB-PA005137	CXCL13 Antibody	Human	WB, ELISA
CSB-PA06139A0Rb	CXCL13 Antibody	Human	ELISA, IHC

CXCL13 Proteins

CXCL13 Proteins for Homo sapiens (Human)

产品货号	产品名称	来源
CSB-YP006243HU CSB-BP006243HU CSB-MP006243HU CSB-EP006243HU-B	Recombinant Human C-X-C motif chemokine 13 (CXCL13)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP006243HU1	Recombinant Human C-X-C motif chemokine 13 protein (CXCL13), partial	E.coli
CSB-AP000771HU	Recombinant Human C-X-C motif chemokine 13 protein (CXCL13)	E.Coli
CSB-EP006243HU	Recombinant Human C-X-C motif chemokine 13 (CXCL13)	E.coli

CXCL13 Proteins for Mus musculus (Mouse)

产品货号	产品名称	来源
CSB-YP006243MO CSB-EP006243MO CSB-BP006243MO CSB-MP006243MO CSB-EP006243MO-B	Recombinant Mouse C-X-C motif chemokine 13 (Cxcl13)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli