CXCR2
CXCR2全称为C-X-C趋化因子受体2型，又称IL-8受体β或CD182，属于G蛋白偶联受体超家族成员。CXCR2通过与IL-8、GROα等趋化因子结合，介导中性粒细胞向炎症部位迁移，在急慢性炎症反应、组织修复及肿瘤微环境调控中发挥关键作用。CXCR2异常活化与慢性阻塞性肺病、银屑病、类风湿性关节炎等炎症性疾病密切相关，其在多种实体瘤中通过招募髓系抑制细胞促进免疫逃逸的特性也备受关注。
针对CXCR2的药物开发聚焦于小分子拮抗剂，如Navarixin（MK-7123）已完成银屑病二期临床试验，AZD5069在慢阻肺治疗中显示出抑制中性粒细胞浸润的效果。由于CXCR2拮抗可能影响正常免疫功能，部分药物因疗效不足或毒副作用终止研发。目前研究转向联合用药策略，如在胰腺癌治疗中与免疫检查点抑制剂联用，或开发双重CXCR1/CXCR2抑制剂以增强抗炎效果。该靶点的组织特异性调控机制仍是转化医学研究的难点。
热销产品
Recombinant Human C-X-C chemokine receptor type 2 (CXCR2), partial (CSB-EP011673HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CXCR2 Antibody (CSB-PA011673HA01HU)
验证数据
Immunohistochemistry of paraffin-embedded human lymph node tissue using CSB-PA011673HA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA011673HA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA011673HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
CXCR2 Antibodies
CXCR2 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA011673GA01HU | CXCR2 Antibody | Human | ELISA,WB,IF |
| CSB-PA974167 | Phospho-CXCR2 (Ser347) Antibody | Human,Mouse | ELISA,WB |
| CSB-PA005633 | CXCR2 Antibody | Human | WB, ELISA |
| CSB-PA009566 | Phospho-CXCR2 (S347) Antibody | Human,Mouse | WB, IHC, IF, ELISA |
| CSB-PA009567 | CXCR2 Antibody | Human,Mouse | IF, ELISA |
| CSB-PA730026 | CXCR2 Antibody | Human | ELISA,WB |
| CSB-PA282080 | CXCR2 Antibody | Human | ELISA,WB |
| CSB-PA011673HA01HU | CXCR2 Antibody | Human | ELISA, IHC, IF |
| CSB-PA011673HB01HU | CXCR2 Antibody, HRP conjugated | Human | ELISA |
CXCR2 Proteins
CXCR2 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP011673HU CSB-BP011673HU CSB-MP011673HU CSB-EP011673HU-B |
Recombinant Human C-X-C chemokine receptor type 2 (CXCR2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP011673HU | Recombinant Human C-X-C chemokine receptor type 2 (CXCR2), partial | E.coli |
| CSB-CF011673HU(A4) | Recombinant Human C-X-C chemokine receptor type 2 (CXCR2) | in vitro E.coli expression system |
CXCR2 Proteins for Oryctolagus cuniculus (Rabbit)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP011673RB1 CSB-EP011673RB1 CSB-BP011673RB1 CSB-MP011673RB1 CSB-EP011673RB1-B |
Recombinant Rabbit C-X-C chemokine receptor type 2 (CXCR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011673RB | Recombinant Rabbit C-X-C chemokine receptor type 2 (CXCR2) | in vitro E.coli expression system |
CXCR2 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP011673RA1 CSB-EP011673RA1 CSB-BP011673RA1 CSB-MP011673RA1 CSB-EP011673RA1-B |
Recombinant Rat C-X-C chemokine receptor type 2 (Cxcr2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011673RA | Recombinant Rat C-X-C chemokine receptor type 2 (Cxcr2) | in vitro E.coli expression system |
CXCR2 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP011673MO1 CSB-EP011673MO1 CSB-BP011673MO1 CSB-MP011673MO1 CSB-EP011673MO1-B |
Recombinant Mouse C-X-C chemokine receptor type 2 (Cxcr2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011673MO | Recombinant Mouse C-X-C chemokine receptor type 2 (Cxcr2) | in vitro E.coli expression system |
| CSB-MP011673MO | Recombinant Mouse C-X-C chemokine receptor type 2 (Cxcr2)-VLPs | Mammalian cell |
CXCR2 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP011673DO1 CSB-EP011673DO1 CSB-BP011673DO1 CSB-MP011673DO1 CSB-EP011673DO1-B |
Recombinant Dog C-X-C chemokine receptor type 2 (CXCR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011673DO | Recombinant Dog C-X-C chemokine receptor type 2 (CXCR2) | in vitro E.coli expression system |
CXCR2 Proteins for Macaca mulatta (Rhesus macaque)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP630684MOW1 CSB-EP630684MOW1 CSB-BP630684MOW1 CSB-MP630684MOW1 CSB-EP630684MOW1-B |
Recombinant Macaca mulatta C-X-C chemokine receptor type 2 (CXCR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF630684MOW | Recombinant Macaca mulatta C-X-C chemokine receptor type 2 (CXCR2) | in vitro E.coli expression system |
CXCR2 Proteins for Pan troglodytes (Chimpanzee)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP631729EQV1 CSB-EP631729EQV1 CSB-BP631729EQV1 CSB-MP631729EQV1 CSB-EP631729EQV1-B |
Recombinant Pan troglodytes C-X-C chemokine receptor type 2 (CXCR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF631729EQV | Recombinant Pan troglodytes C-X-C chemokine receptor type 2 (CXCR2) | in vitro E.coli expression system |
CXCR2 Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP632950BO1 CSB-EP632950BO1 CSB-BP632950BO1 CSB-MP632950BO1 CSB-EP632950BO1-B |
Recombinant Bovine C-X-C chemokine receptor type 2 (CXCR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF632950BO | Recombinant Bovine C-X-C chemokine receptor type 2 (CXCR2) | in vitro E.coli expression system |
CXCR2 Proteins for Gorilla gorilla gorilla (Lowland gorilla)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP636722GGZ1 CSB-EP636722GGZ1 CSB-BP636722GGZ1 CSB-MP636722GGZ1 CSB-EP636722GGZ1-B |
Recombinant Gorilla gorilla gorilla C-X-C chemokine receptor type 2 (CXCR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF636722GGZ | Recombinant Gorilla gorilla gorilla C-X-C chemokine receptor type 2 (CXCR2) | in vitro E.coli expression system |
