CYBB
CYBB全称为细胞色素b-245重链（Cytochrome b-245 heavy chain），又称NOX2或gp91phox，是NADPH氧化酶复合物的核心催化亚基。CYBB主要分布于中性粒细胞、单核细胞等吞噬细胞的细胞膜上，负责催化氧分子生成超氧阴离子，构成机体抵抗病原微生物的关键防线。当免疫细胞识别入侵病原体时，CYBB蛋白会与多个调控亚基组装形成活性酶复合体，通过"呼吸爆发"产生大量活性氧直接杀伤细菌，这一过程被称为氧化杀菌作用。CYBB基因突变会导致慢性肉芽肿病（CGD），患者因无法有效清除病原体而反复发生严重感染，并伴随肉芽肿形成和炎症过度反应。针对该疾病的治疗除了抗生素预防和干扰素-γ辅助治疗外，干细胞基因治疗已进入临床试验阶段，通过回输携带正常CYBB基因的造血干细胞实现功能修复。基于NOX2调控机制的抗氧化剂和抗炎药物研究也为相关免疫缺陷及炎症性疾病提供了新思路。
热销产品
Recombinant Human Cytochrome b-245 heavy chain (CYBB), partial (CSB-EP006325HU1)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CYBB Recombinant Monoclonal Antibody (CSB-RA006325MA1HU)
验证数据
Immunofluorescence staining of hela cell with CSB-RA006325MA1HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L).
CYBB Antibodies
CYBB for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA006325KA01HU | CYBB Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA006325LA01HU | CYBB Antibody | Human | ELISA, IHC, IF |
| CSB-PA006325LC01HU | CYBB Antibody, FITC conjugated | Human | |
| CSB-PA002737 | CYBB Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA005619 | CYBB Antibody | Human | WB, ELISA |
| CSB-PA176464 | CYBB Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA140004 | CYBB Antibody | Human,Mouse | ELISA,IHC |
| CSB-RA006325MA1HU | CYBB Recombinant Monoclonal Antibody | Human | ELISA, IF |
CYBB Proteins
CYBB Proteins for Sus scrofa (Pig)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP006325PI1 CSB-EP006325PI1 CSB-BP006325PI1 CSB-MP006325PI1 CSB-EP006325PI1-B |
Recombinant Pig Cytochrome b-245 heavy chain (CYBB), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006325PI | Recombinant Pig Cytochrome b-245 heavy chain (CYBB) | in vitro E.coli expression system |
CYBB Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP006325HU CSB-EP006325HU CSB-BP006325HU CSB-MP006325HU CSB-EP006325HU-B |
Recombinant Human Cytochrome b-245 heavy chain (CYBB), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP006325HU1 | Recombinant Human Cytochrome b-245 heavy chain (CYBB), partial | E.coli |
| CSB-CF006325HU | Recombinant Human Cytochrome b-245 heavy chain (CYBB) | in vitro E.coli expression system |
| CSB-EP006325HU1a2 | Recombinant Human Cytochrome b-245 heavy chain (CYBB), partial | E.coli |
| CSB-YP006325HU1 | Recombinant Human Cytochrome b-245 heavy chain (CYBB), partial | Yeast |
CYBB Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP006325BO1 CSB-EP006325BO1 CSB-BP006325BO1 CSB-MP006325BO1 CSB-EP006325BO1-B |
Recombinant Bovine Cytochrome b-245 heavy chain (CYBB), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006325BO | Recombinant Bovine Cytochrome b-245 heavy chain (CYBB) | in vitro E.coli expression system |
CYBB Proteins for Escherichia coli (strain K12)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP006306ENV1 CSB-EP006306ENV1 CSB-BP006306ENV1 CSB-MP006306ENV1 CSB-EP006306ENV1-B |
Recombinant Escherichia coli Cytochrome b561 (cybB), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006306ENV | Recombinant Escherichia coli Cytochrome b561 (cybB) | in vitro E.coli expression system |
CYBB Proteins for Shigella flexneri
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP006306SZB1 CSB-EP006306SZB1 CSB-BP006306SZB1 CSB-MP006306SZB1 CSB-EP006306SZB1-B |
Recombinant Cytochrome b561 (cybB), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006306SZB | Recombinant Cytochrome b561 (cybB) | in vitro E.coli expression system |
CYBB Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP733771MO1 CSB-EP733771MO1 CSB-BP733771MO1 CSB-MP733771MO1 CSB-EP733771MO1-B |
Recombinant Mouse Cytochrome b-245 heavy chain (Cybb), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF733771MO | Recombinant Mouse Cytochrome b-245 heavy chain (Cybb) | in vitro E.coli expression system |
CYBB Proteins for Bison bison (American bison) (Bos bison)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP836099BTE1 CSB-EP836099BTE1 CSB-BP836099BTE1 CSB-MP836099BTE1 CSB-EP836099BTE1-B |
Recombinant Bison bison Cytochrome b-245 heavy chain (CYBB), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF836099BTE | Recombinant Bison bison Cytochrome b-245 heavy chain (CYBB) | in vitro E.coli expression system |
CYBB Proteins for Yersinia pestis
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP893085YAS1 CSB-EP893085YAS1 CSB-BP893085YAS1 CSB-MP893085YAS1 CSB-EP893085YAS1-B |
Recombinant Probable cytochrome b561 (cybB), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF893085YAS | Recombinant Probable cytochrome b561 (cybB) | in vitro E.coli expression system |
