EIF4E
EIF4E，即真核翻译起始因子4E，别名eIF4E，是mRNA翻译的关键调控者，源自真核生物细胞。它通过绑定mRNA的5'端帽子结构，引领翻译机器到达mRNA的起始点，解锁mRNA，使之能与核糖体结合，启动蛋白质合成。EIF4E不仅调控基因表达的速度与程度，还参与mRNA稳定性、转运与降解等多个细胞过程。在生物学上，EIF4E的异常调控与多种疾病相关，特别是其高表达常被发现于肿瘤中，成为肿瘤增殖与抗药性的关键因素。因此，EIF4E成为抗癌疗法的新靶点，具有重要的研究与应用价值。
热销产品
Phospho-EIF4E (S209) Recombinant Monoclonal Antibody (CSB-RA007556A209phHU)
验证数据
Western Blot
Positive WB detected in 293 whole cell lysate,HepG2 whole cell lysate(treated with Calyculin A or not)
All lanes Phospho-EIF4E antibody at 1.2μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 25 KDa
Observed band size: 25 KDa
IHC image of CSB-RA007556A209phHU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
EIF4E Antibodies
EIF4E for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA007556GA01HU | EIF4E Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA935753 | Phospho-EIF4E (Ser209) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA190338 | EIF4E (Ab-209) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA000519 | Phospho-EIF4E (S209) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA002308 | EIF4E Antibody | Human,Mouse,Rat,Monkey | WB, IHC, ELISA |
| CSB-PA007556LA01HU | EIF4E Antibody | Human | ELISA, IHC, IF |
| CSB-PA007556LB01HU | EIF4E Antibody, HRP conjugated | Human | ELISA |
| CSB-PA007556LC01HU | EIF4E Antibody, FITC conjugated | Human | |
| CSB-PA007556LD01HU | EIF4E Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA007556A209phHU | Phospho-EIF4E (S209) Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
EIF4E Proteins
EIF4E Proteins for Oryctolagus cuniculus (Rabbit)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP007556RB CSB-EP007556RB CSB-BP007556RB CSB-MP007556RB CSB-EP007556RB-B |
Recombinant Rabbit Eukaryotic translation initiation factor 4E (EIF4E) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EIF4E Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP007556MO CSB-EP007556MO CSB-BP007556MO CSB-MP007556MO CSB-EP007556MO-B |
Recombinant Mouse Eukaryotic translation initiation factor 4E (Eif4e) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EIF4E Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-EP007556HU CSB-BP007556HU CSB-MP007556HU CSB-EP007556HU-B |
Recombinant Human Eukaryotic translation initiation factor 4E (EIF4E) | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP007556HU | Recombinant Human Eukaryotic translation initiation factor 4E (EIF4E) | Yeast |
EIF4E Proteins for Xenopus laevis (African clawed frog)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP007556XBE CSB-EP007556XBE CSB-BP007556XBE CSB-MP007556XBE CSB-EP007556XBE-B |
Recombinant Xenopus laevis Eukaryotic translation initiation factor 4E (eif4e) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EIF4E Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP007556RA CSB-EP007556RA CSB-BP007556RA CSB-MP007556RA CSB-EP007556RA-B |
Recombinant Rat Eukaryotic translation initiation factor 4E (Eif4e) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EIF4E Proteins for Dictyostelium discoideum (Slime mold)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP007556DKK CSB-EP007556DKK CSB-BP007556DKK CSB-MP007556DKK CSB-EP007556DKK-B |
Recombinant Dictyostelium discoideum Eukaryotic translation initiation factor 4E (eif4e) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EIF4E Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP007556BO CSB-EP007556BO CSB-BP007556BO CSB-MP007556BO CSB-EP007556BO-B |
Recombinant Bovine Eukaryotic translation initiation factor 4E (EIF4E) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
