F3

F3，即组织因子，别名CD142、TF、TFA。它是由263个氨基酸残基组成的跨膜单链糖蛋白，分子量约为47 kDa。F3的作用机制是通过与因子VII/VIIa结合启动血液凝固级联反应。它与细胞膜紧密结合，发挥“锚”作用，使生理性凝血过程局限于损伤部位。F3可以同时激活凝血因子Ⅸ和Ⅹ，启动内、外源性两种凝血酶联放大反应，在血栓形成过程中起着重要作用。然而，在生理浓度时，F3和FⅦ单独存在都不具有促凝活性。F3在肿瘤患者中常伴有血液凝固性增强，并且在肿瘤组织中也常见血栓的形成，这可能与肿瘤血管内皮细胞和肿瘤细胞上组织因子F3的异常高表达相关。F3的高表达直接影响细胞增殖、组织浸润性、转移性等生物学特征，已成为肿瘤研究中颇具潜力的治疗靶标。

热销产品

Recombinant Human Tissue factor(F3),partial (Active) (CSB-MP007928HU2)

验证数据

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human TF at 2 μg/ml can bind Anti-TF recombinant antibody (CSB-RA007928MA2HU). The EC₅₀ is 1.434-1.635 ng/mL.

The purity of F3 was greater than 95% as determined by SEC-HPLC

F3 Antibody

F3 Protein

F3 ELISA Kit

F3 Antibodies

F3 for Homo sapiens (Human)

产品货号	产品名称	种属反应性	应用类型
CSB-PA007928LA01HU	F3 Antibody	Human, Mouse	ELISA, WB, IHC, IF
CSB-PA004263	F3 Antibody	Human,Monkey	WB, ELISA
CSB-PA005114	F3 Antibody	Human	WB, ELISA
CSB-PA008166	Phospho-F3 (S290) Antibody	Human	WB, IHC, ELISA
CSB-PA040718	F3 Antibody	Human	ELISA,WB,IHC
CSB-PA981490	F3 Antibody	Human	ELISA,IHC
CSB-RA776663A0HU	F3 Recombinant Monoclonal Antibody	Human, Rat	ELISA, WB, IHC

F3 Proteins

F3 Proteins for Homo sapiens (Human)

产品货号	产品名称	来源
CSB-BP007928HU1 CSB-MP007928HU1 CSB-EP007928HU1-B	Recombinant Human Tissue factor (F3), partial	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF007928HU	Recombinant Human Tissue factor (F3)	in vitro E.coli expression system
CSB-EP007928HU1	Recombinant Human Tissue factor (F3), partial	E.coli
CSB-EP007928HU(F2)	Recombinant Human Tissue factor (F3)	E.coli
CSB-MP007928HU2	Recombinant Human Tissue factor(F3),partial (Active)	Mammalian cell
CSB-MP007928HU-WD	Recombinant Human Tissue factor (F3), partial	Mammalian cell

F3 Proteins for Mus musculus (Mouse)

产品货号	产品名称	来源
CSB-YP007928MO1 CSB-EP007928MO1 CSB-BP007928MO1 CSB-EP007928MO1-B	Recombinant Mouse Tissue factor (F3), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-CF007928MO	Recombinant Mouse Tissue factor (F3)	in vitro E.coli expression system

F3 Proteins for Oryctolagus cuniculus (Rabbit)

产品货号	产品名称	来源
CSB-YP007928RB1 CSB-EP007928RB1 CSB-BP007928RB1 CSB-MP007928RB1 CSB-EP007928RB1-B	Recombinant Rabbit Tissue factor (F3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF007928RB	Recombinant Rabbit Tissue factor (F3)	in vitro E.coli expression system

F3 Proteins for Bos taurus (Bovine)

产品货号	产品名称	来源
CSB-YP007928BO1 CSB-EP007928BO1 CSB-BP007928BO1 CSB-MP007928BO1 CSB-EP007928BO1-B	Recombinant Bovine Tissue factor (F3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF007928BO	Recombinant Bovine Tissue factor (F3)	in vitro E.coli expression system

F3 Proteins for Microplitis demolitor bracovirus (isolate Webb) (MdBV)

产品货号	产品名称	来源
CSB-YP686307MDAK CSB-EP686307MDAK CSB-BP686307MDAK CSB-MP686307MDAK CSB-EP686307MDAK-B	Recombinant Microplitis demolitor bracovirus I-Kappa-B like protein F2 (F3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

F3 Proteins for Cavia porcellus (Guinea pig)

产品货号	产品名称	来源
CSB-YP888355GU CSB-EP888355GU CSB-BP888355GU CSB-MP888355GU CSB-EP888355GU-B	Recombinant Guinea pig Tissue factor (F3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli