FCGR3A
FCGR3A，即Fc片段的IgG受体IIIa，别名CD16a。它是一种低亲和力的IgG Fc区受体，属于免疫球蛋白超家族成员，主要表达在自然杀伤(NK)细胞、巨噬细胞、肥大细胞和中性粒细胞等免疫效应细胞表面。FCGR3A通过与IgG1和IgG3的Fc段结合，诱导免疫效应细胞的细胞毒作用，即抗体依赖的细胞介导的细胞毒作用(ADCC)，杀伤靶细胞，也可促进IFN-γ、TNF和基质金属蛋白酶等细胞因子的分泌，影响细胞免疫功能发挥。FCGR3A在生物学上的意义主要体现在其参与的多种免疫反应中。它不仅在NK细胞介导的ADCC中发挥作用，还是单克隆抗体介导的分子靶向治疗的重要结合位点，尤其在恶性肿瘤治疗中应用广泛。此外，FCGR3A的基因多态性与某些癌症的治疗反应相关，其表达水平可能与肿瘤的预后相关，有助于作为预后生物标志物。FCGR3A的表达还与免疫检查点分子以及肿瘤相关巨噬细胞(TAM)基因标志物呈正相关，表明其在肿瘤免疫微环境中可能发挥重要作用。
热销产品
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
FCGR3A Recombinant Monoclonal Antibody (CSB-RA008543MA1HU)
验证数据
Immunofluorescence staining of Hela cell with CSB-RA008543MA1HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
FCGR3A Antibodies
FCGR3A for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA287660 | FCGR3A Antibody | Human | ELISA,IHC |
| CSB-PA183080 | FCGR3A Antibody | Human | ELISA,IHC |
| CSB-PA008543LA01HU | FCGR3A Antibody | Human | ELISA, IHC, IF |
| CSB-PA008543LB01HU | FCGR3A Antibody, HRP conjugated | Human | ELISA |
| CSB-PA008543LC01HU | FCGR3A Antibody, FITC conjugated | Human | |
| CSB-PA008543LD01HU | FCGR3A Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA008543MA1HU | FCGR3A Recombinant Monoclonal Antibody | Human | ELISA, IF |
FCGR3A Proteins
FCGR3A Proteins for Homo sapiens (Human)
FCGR3A Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP303590BO CSB-EP303590BO CSB-BP303590BO CSB-MP303590BO CSB-EP303590BO-B |
Recombinant Bovine Low affinity immunoglobulin gamma Fc region receptor III (FCGR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FCGR3A Proteins for Macaca mulatta (Rhesus macaque)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP388701MOW CSB-EP388701MOW CSB-BP388701MOW CSB-MP388701MOW CSB-EP388701MOW-B |
Recombinant Macaca mulatta Low affinity immunoglobulin gamma Fc region receptor III (FCGR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FCGR3A Proteins for Sus scrofa (Pig)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP636747PI CSB-EP636747PI CSB-BP636747PI CSB-MP636747PI CSB-EP636747PI-B |
Recombinant Pig Low affinity immunoglobulin gamma Fc region receptor III (FCGR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FCGR3A Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP854680MOV CSB-EP854680MOV CSB-BP854680MOV CSB-MP854680MOV CSB-EP854680MOV-B |
Recombinant Macaca fascicularis Low affinity immunoglobulin gamma Fc region receptor III (FCGR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FCGR3A ELISA Kit
FCGR3A ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-EL008543HU | Human Low affinity immunoglobulin gamma Fc region receptor III-A(FCGR3A) ELISA kit | serum, plasma, tissue homogenates | 11.75 pg/mL |
