FGG
纤维蛋白原γ链（Fibrinogen Gamma Chain，FGG）是纤维蛋白原复合物的核心组分，与α、β链共同构成血浆中重要的凝血蛋白，在UniProt中记录为FGgamma或Fibrinogen gamma polypeptide。该蛋白在凝血级联反应中发挥关键作用，凝血酶将其切割后释放纤维蛋白单体，通过交联形成网状结构，稳定血栓并促进伤口愈合。其异常表达或功能缺陷可能引发先天性纤维蛋白原缺乏症，表现为出血倾向或异常血栓形成，部分突变还与遗传性淀粉样变性相关。临床研究发现，血浆FGG水平升高与动脉粥样硬化、深静脉血栓及肿瘤转移风险显著相关，尤其在肝癌、胰腺癌中常作为预后标志物。目前针对纤维蛋白原的药物以抗凝剂为主，如直接凝血酶抑制剂比伐卢定，而针对FGG特异性的单克隆抗体尚处于临床前研究阶段。近年来，基于FGG结构设计的靶向纤维蛋白溶解疗法在溶栓药物开发中受到关注，例如改良型组织纤溶酶原激活剂（tPA）的增效策略已进入Ⅱ期临床试验。
热销产品
Recombinant Human Fibrinogen gamma chain (FGG) (CSB-EP008651HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
FGG Antibody (CSB-PA008651LA01HU)
验证数据
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA008651LA01HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA008651LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Western Blot
Positive WB detected in: Mouse heart tissue
All lanes: FGG antibody at 2.7μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 52, 50 kDa
Observed band size: 52 kDa
Human Fibrinogen Gamma Chain (FGG)ELISA Kit (CSB-E13319h)
验证数据
货号：CSB-E13319h
规格：96T/48T
灵敏度：31.25 ng/mL
检测范围：125 ng/mL-8000 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
FGG Antibodies
FGG for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA008651GA01HU | FGG Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA008651LA01HU | FGG Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA008651LB01HU | FGG Antibody, HRP conjugated | Human | ELISA |
| CSB-PA008651LC01HU | FGG Antibody, FITC conjugated | Human | |
| CSB-PA008651LD01HU | FGG Antibody, Biotin conjugated | Human | ELISA |
FGG Proteins
FGG Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008651DO CSB-EP008651DO CSB-BP008651DO CSB-MP008651DO CSB-EP008651DO-B |
Recombinant Dog Fibrinogen gamma chain (FGG) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FGG Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008651RA CSB-EP008651RA CSB-BP008651RA CSB-MP008651RA CSB-EP008651RA-B |
Recombinant Rat Fibrinogen gamma chain (Fgg) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FGG Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008651HU CSB-BP008651HU CSB-MP008651HU CSB-EP008651HU-B |
Recombinant Human Fibrinogen gamma chain (FGG) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP008651HU | Recombinant Human Fibrinogen gamma chain (FGG) | E.coli |
FGG Proteins for Xenopus laevis (African clawed frog)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008651XBE CSB-EP008651XBE CSB-BP008651XBE CSB-MP008651XBE CSB-EP008651XBE-B |
Recombinant Xenopus laevis Fibrinogen gamma chain (fgg) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FGG Proteins for Petromyzon marinus (Sea lamprey)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008651EUC CSB-EP008651EUC CSB-BP008651EUC CSB-MP008651EUC CSB-EP008651EUC-B |
Recombinant Petromyzon marinus Fibrinogen gamma chain (FGG) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FGG Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008651MO CSB-EP008651MO CSB-BP008651MO CSB-MP008651MO CSB-EP008651MO-B |
Recombinant Mouse Fibrinogen gamma chain (Fgg) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FGG ELISA Kit
FGG ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E13319h | Human Fibrinogen Gamma Chain (FGG)ELISA Kit | serum, plasma, tissue homogenates | 31.25 ng/mL |
