FOSL1
FOSL1（FOS-like antigen 1）又称Fra-1，属于AP-1转录因子家族成员，在细胞增殖、分化和凋亡中发挥调控作用。FOSL1通过与JUN家族蛋白形成二聚体，结合特定DNA序列激活下游靶基因，尤其与肿瘤侵袭转移密切相关。有研究发现，FOSL1在乳腺癌、结直肠癌和肺癌等多种恶性肿瘤中异常高表达，通过诱导上皮间质转化（EMT）促进癌细胞迁移，并与血管生成、化疗耐药等恶性表型相关。其活性受MAPK/ERK和JNK等信号通路调控，与炎症因子TNF-α、IL-6的表达也存在交叉调控。目前针对FOSL1尚无直接靶向药物，但针对其上游信号分子开发的MEK抑制剂（如曲美替尼）已在临床试验中验证对部分肿瘤的疗效。近年研究发现，天然化合物姜黄素可通过抑制FOSL1表达延缓肿瘤进展，为联合用药提供了新方向。
热销产品
FOSL1 Antibody (CSB-PA008792DSR1HU)
验证数据
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA008792DSR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA008792DSR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA008792DSR1HU at dilution of 1:100
FOSL1 Antibodies
FOSL1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA679637 | FOSL1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA008792DSR1HU | FOSL1 Antibody | Human | ELISA, IHC |
| CSB-PA002578 | FOSL1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA940383 | FOSL1 Antibody | Human,Rat | ELISA,WB |
| CSB-PA569524 | FOSL1 Antibody | Human,Rat | ELISA,WB,IHC |
FOSL1 Proteins
FOSL1 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008792RA CSB-EP008792RA CSB-BP008792RA CSB-MP008792RA CSB-EP008792RA-B |
Recombinant Rat Fos-related antigen 1 (Fosl1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FOSL1 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008792HU CSB-EP008792HU CSB-BP008792HU CSB-MP008792HU CSB-EP008792HU-B |
Recombinant Human Fos-related antigen 1 (FOSL1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FOSL1 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008792MO CSB-BP008792MO CSB-MP008792MO CSB-EP008792MO-B |
Recombinant Mouse Fos-related antigen 1 (Fosl1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
