FZD7
FZD7（Frizzled-7）是卷曲蛋白家族成员之一，别名Fz-7或hFz7。这类跨膜受体蛋白通过与Wnt蛋白配体结合，调控胚胎发育、组织稳态等重要生理过程。FZD7激活后主要介导Wnt/β-catenin经典通路，促进β-catenin入核启动靶基因转录，同时也能通过非经典通路影响细胞极性和迁移。FZD7在多种恶性肿瘤中异常高表达，包括结直肠癌、三阴性乳腺癌和肝细胞癌，其过表达与肿瘤干细胞特性增强、化疗耐药及转移密切相关。目前针对FZD7的靶向药物开发尚处早期阶段，已有研究报道通过单克隆抗体阻断其与Wnt配体结合，在动物模型中显示出抑制肿瘤生长的效果。
热销产品
验证数据
Western Blot analysis of HELA cells using Frizzled-7 Polyclonal Antibody
Western Blot analysis of HELA cells using Frizzled-7 Polyclonal Antibody
FZD7 Antibodies
FZD7 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA009110GA01HU | FZD7 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA002581 | FZD7 Antibody | Human,Mouse | WB, IF, ELISA |
| CSB-PA009110LA01HU | FZD7 Antibody | Human | ELISA, WB, IHC |
| CSB-PA009110LB01HU | FZD7 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA009110LC01HU | FZD7 Antibody, FITC conjugated | Human |
FZD7 Proteins
FZD7 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP009110HU1 CSB-EP009110HU1 CSB-BP009110HU1 CSB-MP009110HU1 CSB-EP009110HU1-B |
Recombinant Human Frizzled-7 (FZD7), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF009110HU | Recombinant Human Frizzled-7 (FZD7) | in vitro E.coli expression system |
FZD7 Proteins for Gallus gallus (Chicken)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP009110CH1 CSB-EP009110CH1 CSB-BP009110CH1 CSB-MP009110CH1 CSB-EP009110CH1-B |
Recombinant Chicken Frizzled-7 (FZD7), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF009110CH | Recombinant Chicken Frizzled-7 (FZD7) | in vitro E.coli expression system |
FZD7 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP704724XBF1 CSB-EP704724XBF1 CSB-BP704724XBF1 CSB-MP704724XBF1 CSB-EP704724XBF1-B |
Recombinant Xenopus tropicalis Frizzled-7 (fzd7), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF704724XBF | Recombinant Xenopus tropicalis Frizzled-7 (fzd7) | in vitro E.coli expression system |
FZD7 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP730721MO1 CSB-EP730721MO1 CSB-BP730721MO1 CSB-MP730721MO1 CSB-EP730721MO1-B |
Recombinant Mouse Frizzled-7 (Fzd7), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF730721MO | Recombinant Mouse Frizzled-7 (Fzd7) | in vitro E.coli expression system |
